> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/angptl3-28ff9f94-9797-5f15-b225-9e6e1b7b004a
> Record changed: 2026-10-13

# ANGPTL3

ENSG00000132855

Target class

Unclassified protein

Chromosome

1

Approved drugs

1

Clinical candidates (approved and in development)

1

## Clinical evidence

**Approved drugs**

1

**ClinGen gene-disease validity**

Definitive

**Clinical candidates (approved and in development)**

1

## Druggability

**Chemical probe available**

No

## Names

**Target name**

ANGPTL3

**Gene name**

Angiopoietin like 3

**Gene symbol**

ANGPTL3

**Previous gene symbols**

- ANGPT5

**Protein name**

Angiopoietin-related protein 3 (Angiopoietin-5) (ANG-5) (Angiopoietin-like protein 3) \[Cleaved into: ANGPTL3(17-221); ANGPTL3(17-224)\]

## Classification

**Gene biotype**

Protein coding

**Gene family**

Receptor ligands|Fibrinogen C domain containing|Angiopoietin like family

**Target class**

Unclassified protein

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

4

**Highest tissue expression**

133.78

**Tissue specificity (Gini)**

0.954

**Tissue specificity (tau)**

0.998

## Pathways and interactions

**KEGG gene identifiers**

- hsa:27329

**Protein interaction confidence**

0.839167

**Protein interaction partners**

12

### Reactome pathways (2)

- R-HSA-8963889
- R-HSA-9029558

## Genomic location

**End position**

62607196

**Start position**

62597464

**Chromosome**

1

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000132855

**HGNC ID**

HGNC:491

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:491)

**NCBI Gene ID**

27329

**UniProt ID**

Q9Y5C1

## Cellular location

- Secreted . Cell projection, lamellipodium . Note=Colocalized with HSPG2 and activated ITGB3 on podocytes. .

### Publication evidence

- PubMed 11877390  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11877390/)

## Tissue expression

**Tissue specificity (tau)**

0.997944

**Expression inequality (Gini)**

0.953569

### Highest expression

Expression in transcripts per million

**Liver**

133.78

**Kidney - Cortex**

5.13

**Kidney - Medulla**

1.96

**Stomach**

1.65

**Pituitary**

0.45

### All tissues (54)

Expression in transcripts per million

- Liver133.78
- Kidney - Cortex5.13
- Kidney - Medulla1.96
- Stomach1.65
- Pituitary0.45
- Ovary0.41
- Cervix - Ectocervix0.29
- Artery - Aorta0.28
- Testis0.28
- Uterus0.25
- Vagina0.25
- Cervix - Endocervix0.25
- Minor Salivary Gland0.22
- Nerve - Tibial0.19
- Artery - Tibial0.19
- Thyroid0.17
- Skin - Not Sun Exposed (Suprapubic)0.17
- Fallopian Tube0.16
- Prostate0.16
- Artery - Coronary0.16
- Bladder0.15
- Pancreas0.15
- Brain - Cerebellum0.11
- Lung0.11
- Skin - Sun Exposed (Lower leg)0.11

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (19)

- GO:0006071  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006071)
- GO:0006631  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006631)
- GO:0006644  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006644)
- GO:0007160  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007160)
- GO:0007165  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165)
- GO:0008203  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008203)
- GO:0009395  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009395)
- GO:0010903  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010903)
- GO:0019915  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019915)
- GO:0030335  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030335)
- GO:0042632  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042632)
- GO:0045766  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045766)
- GO:0050996  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050996)
- GO:0055088  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055088)
- GO:0055090  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055090)
- GO:0055091  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055091)
- GO:0070328  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070328)
- GO:0090318  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090318)
- GO:1905883  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1905883)

### Cellular components (2)

- GO:0005576  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576)
- GO:0009986  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986)

### Molecular functions (5)

- GO:0004859  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004859)
- GO:0005178  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005178)
- GO:0008083  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008083)
- GO:0035473  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035473)
- GO:0055102  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055102)

## Related records

### Trials (20)

- A Dose-Ranging Study With Vupanorsen (TRANSLATE-TIMI 70)
- A Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Tolerability Of Single Dose Vupanorsen In Healthy Chinese Adults
- Compassionate Use of Evinacumab
- Efficacy and Safety of Evinacumab in Adult Patients With Severe Hypertriglyceridemia for the Prevention of Recurrent Acute Pancreatitis
- Efficacy and Safety of Evinacumab in Patients With Homozygous Familial Hypercholesterolemia
- Evaluate the Efficacy and Safety of Evinacumab in Pediatric Patients With Homozygous Familial Hypercholesterolemia
- Evaluate the Long-Term Safety and Efficacy of Evinacumab in Patients With Homozygous Familial Hypercholesterolemia
- Investigation Of Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Of Single Doses Of Vupanorsen In Japanese Healthy Adult Participants With Elevated Triglycerides
- Phase 2 Study of AKCEA-ANGPTL3-LRx (ISIS 703802) in Participants With Familial Chylomicronemia Syndrome (FCS)
- Safety and Effectiveness of Evinacumab for the Treatment of Homozygous Familial Hypercholesterolemia
- Safety and Efficacy Following Repeat-Dose of Evinacumab (Anti-ANGPTL3) in Patients With Severe Hypertriglyceridemia (sHTG) at Risk for Acute Pancreatitis
- Study of AKCEA-ANGPTL3-LRx (ISIS 703802) in Participants With Familial Partial Lipodystrophy (FPL)
- Study of AKCEA-ANGPTL3-LRX (ISIS 703802) in Patients With Homozygous Familial Hypercholesterolemia (HoFH)
- Study of Evinacumab (REGN1500) in Caucasian and in Japanese Healthy Volunteers
- Study of Evinacumab (REGN1500) in Participants With Persistent Hypercholesterolemia
- Study of ISIS 703802 in Participants With Hypertriglyceridemia, Type 2 Diabetes Mellitus, and Nonalcoholic Fatty Liver Disease
- Study of REGN1500 in Participants With Homozygous Familial Hypercholesterolemia (HoFH)
- [Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease](https://trialight.com/data/trial/study-to-assess-the-effects-of-angiopoietin-like-protein-3-7440e204-563e-4cf8-aefe-6a79062af0b9.md)
- Study to Assess the Safety and Tolerability of Multiple Ascending Doses of REGN1500
- Study to Assess the Safety and Tolerability of Single Doses of REGN1500

### Drugs (3)

- [Evinacumab](https://trialight.com/data/asset/evinacumab-756ee795-e24e-4f94-87b2-19f7d738fbc8.md) Angiopoietin-related protein 3 inhibitor
- Vupanorsen Angiopoietin like 3 (ANGPTL3) mRNA antisense inhibitor
- Vupanorsen sodium Angiopoietin like 3 (ANGPTL3) mRNA antisense inhibitor

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