> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/angpt2-0da1d20a-ff23-5742-83b2-f27f1c4e3930 > Record changed: 2026-10-13 # ANGPT2 ENSG00000091879 Target class Unclassified protein Chromosome 8 Approved drugs 1 Clinical candidates (approved and in development) 8 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 8 ## Druggability **Chemical probe available** No ## Names **Other names** - Ang2 **Target name** ANGPT2 **Gene name** Angiopoietin 2 **Gene symbol** ANGPT2 **Protein name** Angiopoietin-2 (ANG-2) ## Classification **Gene biotype** Protein coding **Gene family** Receptor ligands|Fibrinogen C domain containing|Angiopoietins **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 40 **Highest tissue expression** 17.7 **Tissue specificity (Gini)** 0.517 **Tissue specificity (tau)** 0.848 ## Pathways and interactions **KEGG gene identifiers** - hsa:285 **Reactome pathways** - R-HSA-210993 **Protein interaction confidence** 0.815634 **Protein interaction partners** 41 ## Genomic location **End position** 6563409 **Start position** 6499632 **Chromosome** 8 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000091879 **HGNC ID** HGNC:485 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:485) **NCBI Gene ID** 285 **UniProt ID** O15123 ## Cellular location - Secreted . ### Publication evidence - PubMed 32908006 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/32908006/) ## Tissue expression **Tissue specificity (tau)** 0.848342 **Expression inequality (Gini)** 0.516811 ### Highest expression Expression in transcripts per million **Artery - Tibial** 17.7 **Adipose - Subcutaneous** 13.27 **Adipose - Visceral (Omentum)** 10.87 **Thyroid** 9.54 **Breast - Mammary Tissue** 8.27 ### All tissues (54) Expression in transcripts per million - Artery - Tibial17.7 - Adipose - Subcutaneous13.27 - Adipose - Visceral (Omentum)10.87 - Thyroid9.54 - Breast - Mammary Tissue8.27 - Artery - Coronary6.13 - Artery - Aorta5.44 - Fallopian Tube5.05 - Kidney - Medulla4.56 - Cervix - Endocervix4.18 - Cervix - Ectocervix4.04 - Nerve - Tibial3.93 - Bladder3.91 - Lung3.77 - Uterus3.75 - Brain - Spinal cord (cervical c-1)3.49 - Vagina3.12 - Prostate3.08 - Skin - Sun Exposed (Lower leg)2.49 - Esophagus - Muscularis2.49 - Ovary2.32 - Esophagus - Gastroesophageal Junction2.19 - Brain - Hypothalamus2.18 - Brain - Substantia nigra2.17 - Heart - Atrial Appendage2.09 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (7) - GO:0001525 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001525) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0010467 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010467) - GO:0043537 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043537) - GO:0048014 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048014) - GO:0050820 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050820) - GO:0050928 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050928) ### Cellular components - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) ### Molecular functions (4) - GO:0005102 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005102) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0030971 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030971) - GO:0048018 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048018) ## Related records ### Trials (98) - A Pharmacokinetic Study of AMG 386 in Cancer Subjects With Normal and Impaired Renal Function - A Phase 1 Dose Escalation Study of AMG 780 in Adult Subjects With Advanced Solid Tumors - A Phase 1 Study Evaluating the Safety, Tolerability and Pharmacokinetics of Trebananib (AMG 386 ) in Adult Japanese Participants With Advanced Solid Tumors - [A Phase 1b Study to Assess the Safety, Tolerability, Pharmacokinetics, and Exploratory Efficacy of Intravitreal OLN324](https://trialight.com/data/trial/a-phase-1b-study-to-assess-the-safety-tolerability-88c39e5d-c96a-470d-8fb1-844fe0024875.md) - A Phase 2, Randomized, Double Blind, Placebo Controlled Study of AMG 386 in Combination With FOLFIRI in Subjects With Previously Treated Metastatic Colorectal Carcinoma - A Proof-of-Concept Study of Faricimab (RO6867461) in Participants With Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD) - A Prospective Longitudinal Analysis of Faricimab (Vabysmo 6mg) For Choroidal Neovascularization in Presumed Ocular Histoplasmosis Syndrome - A Real-World Study to Gain Clinical Insights Into Faricimab (FaReal Study) - A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products - A Study Comparing the Efficacy and Safety of Vanucizumab and FOLFOX With Bevacizumab and FOLFOX in Participants With Untreated Metastatic Colorectal Cancer - A Study in Patients With Neovascular Age-Related Macular Degeneration or Diabetic Macular Edema to Evaluate the Safety of the Faricimab Prefilled Syringe - A Study of Faricimab (RO6867461) in Participants With Center-Involving Diabetic Macular Edema - A Study of LY3127804 in Participants With COVID-19 - A Study of LY3127804 With Ramucirumab in Participants With Advanced Solid Tumors - A Study of RO6867461 Administered in Single- and Multiple-Ascending Doses in Patients With Wet Age-Related Macular Degeneration - A Study of the Effectiveness and Safety of AMG 386 and Sorafenib to Treat Advanced or Inoperable Hepatocellular Cancer - A Study of Vanucizumab (RO5520985) Alone or in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors - A Study to Determine the Efficacy, Safety, and Durability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration - A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Edema - A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Edema (YOSEMITE) ### Drugs (8) - AMG-780 Angiopoietin-2 inhibitor - CVX-060 Angiopoietin-2 inhibitor - [Faricimab](https://trialight.com/data/asset/faricimab-499c6bdf-255b-4e85-beb1-4b97ebbeaf6f.md) Angiopoietin-2 inhibitor - MEDI-3617 Angiopoietin-2 inhibitor - Nesvacumab Angiopoietin-2 inhibitor - Trebananib Angiopoietin-2 inhibitor - Vanucizumab Angiopoietin-2 inhibitor - Zansecimab Angiopoietin-2 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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