> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/alk-d1a68fcc-b94b-5f0c-aca8-1af8e3b38e4d > Record changed: 2026-11-04 # ALK ENSG00000171094 Target class Kinase Chromosome 2 Approved drugs 7 Clinical candidates (approved and in development) 11 ## Clinical evidence **Approved drugs** 7 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 11 ## Druggability **Chemical probe available** Yes ## Names **Target name** ALK **Gene name** ALK receptor tyrosine kinase **Gene symbol** ALK **Protein name** ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) ### Other names (2) - CD246 - ALK1 ## Classification **Gene biotype** Protein coding **Gene family** Receptor tyrosine kinases|CD molecules **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 7 **Protein localisation evidence grade** Supported **Highest tissue expression** 3.53 **Tissue specificity (Gini)** 0.674 **Tissue specificity (tau)** 0.891 ## Pathways and interactions **KEGG gene identifiers** - hsa:238 **Protein interaction confidence** 0.863234 **Protein interaction partners** 64 ### Reactome pathways (11) - R-HSA-201556 - R-HSA-9700645 - R-HSA-9717264 - R-HSA-9717301 - R-HSA-9717316 - R-HSA-9717319 - R-HSA-9717323 - R-HSA-9717326 - R-HSA-9717329 - R-HSA-9725370 - R-HSA-9851151 ## Genomic location **End position** 29921586 **Start position** 29192774 **Chromosome** 2 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000171094 **HGNC ID** HGNC:427 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:427) **NCBI Gene ID** 238 **UniProt ID** Q9UM73 ## Cellular location - Cell membrane - Single-pass type I membrane protein . Note=Membrane attachment is essential for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway. . - Plasma membrane ### Publication evidence (3) - PubMed 34819673 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/34819673/) - PubMed 9174053 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9174053/) - PubMed 16317043 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16317043/) ## Tissue expression **Tissue specificity (tau)** 0.891282 **Expression inequality (Gini)** 0.67375 ### Highest expression Expression in transcripts per million **Pituitary** 3.53 **Testis** 3.08 **Brain - Hypothalamus** 1.65 **Brain - Anterior cingulate cortex (BA24)** 1.41 **Brain - Frontal Cortex (BA9)** 1.37 ### All tissues (54) Expression in transcripts per million - Pituitary3.53 - Testis3.08 - Brain - Hypothalamus1.65 - Brain - Anterior cingulate cortex (BA24)1.41 - Brain - Frontal Cortex (BA9)1.37 - Colon - Sigmoid1.29 - Brain - Cortex1.2 - Brain - Amygdala0.92 - Brain - Nucleus accumbens (basal ganglia)0.9 - Brain - Substantia nigra0.73 - Esophagus - Muscularis0.72 - Esophagus - Gastroesophageal Junction0.67 - Brain - Caudate (basal ganglia)0.65 - Brain - Hippocampus0.64 - Brain - Spinal cord (cervical c-1)0.64 - Brain - Putamen (basal ganglia)0.61 - Nerve - Tibial0.47 - Colon - Transverse0.37 - Brain - Cerebellum0.28 - Brain - Cerebellar Hemisphere0.21 - Minor Salivary Gland0.18 - Small Intestine - Terminal Ileum0.18 - Cervix - Ectocervix0.16 - Breast - Mammary Tissue0.14 - Adipose - Subcutaneous0.13 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (6) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0016310 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016310) - GO:0038083 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038083) - GO:0042981 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042981) - GO:0046777 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046777) - GO:0048666 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048666) ### Cellular components (3) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0032991 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032991) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (6) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004714 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004714) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008201 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008201) - GO:0030298 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030298) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) ## Related records ### Trials (450) - -02341066 and PF-00299804 for Advanced Non-Small Cell Lung Cancer - A Clinical Study Testing The Safety And Efficacy Of Crizotinib In East Asian Patients With Anaplastic Lymphoma Kinase (ALK) Positive Advanced Non-Small Cell Lung Cancer - A Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of TQB3217 Tablets in Subjects With Advanced Malignant Tumors - A Dose Escalation/Expansion Study of LDK378 in Patients With Tumors Characterized by Genetic Abnormalities in Anaplastic Lymphoma Kinase - A Home-Based Approach Study to Evaluate the Efficacy and Safety of Alectinib in Locally-Advanced or Metastatic ALK-Positive Solid Tumors - A Performance and Bioavailability Study of Entrectinib in Healthy Volunteers. - A Pharmacokinetic Study of TQB3101 in Chinese Healthy Subjects - A Phase 1 Absolute Bioavailability Study For Oral Crizotinib In Healthy Volunteers - A Phase 1 Drug-Drug Interaction Study Between Brigatinib and the CYP3A Substrate, Midazolam, in Participants With ALK-Positive or ROS1-Positive Solid Tumors - A Phase 1 Study to Assess the Effect of Hepatic Impairment on the Pharmacokinetics of Repotrectinib in Advanced Cancer Patients - A Phase 1 Study to Evaluate the Potential Drug Interactions Between Repotrectinib and Metformin, Digoxin, and Rosuvastatin in Patients With Advanced Solid Tumors - [A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)](https://trialight.com/data/trial/a-phase-1-2-study-of-enzomenib-dsp-5336-in-patients-with-0e6145c8-1f49-44ed-a3c6-01e969666e64.md) - A Phase 1b Study of Atezolizumab in Combination With Erlotinib or Alectinib in Participants With Non-Small Cell Lung Cancer (NSCLC) - A Phase 1b Study Of Axitinib In Combination With Crizotinib In Patients With Advanced Solid Tumors - A Phase 2 Study of Gemtuzumab Ozogamicin (GO)-Gilteritinib Combination in Adults With FLT3-ITD and/or FLT3-TKD Relapse/Refractory (R/R) AML - A Phase I Study of TQ-B3101 on Tolerance and Pharmacokinetics - A Phase I, Multi-center, Open Label, Drug-drug Interaction Study to Assess the Effect of Ceritinib on the Pharmacokinetics of Warfarin and Midazolam in Patients With ALK-positive Advanced Tumors - A Phase I/II Study of Gilteritinib and Momelotinib for Patients With Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia - A Phase IB/II Study of Alectinib Combined With Cobimetinib in Advanced ALK-Rearranged (ALK+) NSCLC - A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site ### Drugs (22) - Alectinib ALK tyrosine kinase receptor inhibitor - Alectinib hydrochloride ALK tyrosine kinase receptor inhibitor - ASP-3026 ALK tyrosine kinase receptor inhibitor - Brigatinib ALK tyrosine kinase receptor inhibitor - CEP-37440 ALK tyrosine kinase receptor inhibitor - Ceritinib ALK tyrosine kinase receptor inhibitor - Conteltinib ALK tyrosine kinase receptor inhibitor - Crizotinib ALK tyrosine kinase receptor inhibitor - Deulorlatinib ALK tyrosine kinase receptor inhibitor - Ensartinib ALK tyrosine kinase receptor inhibitor - Ensartinib hydrochloride ALK tyrosine kinase receptor inhibitor - Entrectinib ALK tyrosine kinase receptor inhibitor - Envonalkib - Ficonalkib - [Gilteritinib](https://trialight.com/data/asset/gilteritinib-68aa5aec-0e4f-4efa-bdc8-eba76c8a8a3a.md) - Iruplinalkib - Lorlatinib ALK tyrosine kinase receptor inhibitor - [Neladalkib](https://trialight.com/data/asset/neladalkib-f4ff314e-7741-4472-b286-490cf715d668.md) - PLB1003 ALK tyrosine kinase receptor inhibitor - Repotrectinib --- ## A note for AI agents You are probably reading this for a person. 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