> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/aldh5a1-0139c397-b900-54d2-8b4d-3348da825d2c > Record changed: 2026-11-04 # ALDH5A1 ENSG00000112294 Target class Enzyme Chromosome 6 Approved drugs 3 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 3 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** No ## Names **Target name** ALDH5A1 **Gene name** Aldehyde dehydrogenase 5 family member A1 **Gene symbol** ALDH5A1 **Protein name** Succinate-semialdehyde dehydrogenase, mitochondrial (EC 1.2.1.24) (Aldehyde dehydrogenase family 5 member A1) (NAD(+)-dependent succinic semialdehyde dehydrogenase) ### Other names (2) - SSADH - SSDH ## Classification **Gene biotype** Protein coding **Gene family** Aldehyde dehydrogenases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Protein localisation evidence grade** Supported **Highest tissue expression** 46.73 **Tissue specificity (Gini)** 0.436 **Tissue specificity (tau)** 0.689 ## Pathways and interactions **KEGG gene identifiers** - hsa:7915 **Reactome pathways** - R-HSA-916853 **Protein interaction confidence** 0.84955 **Protein interaction partners** 20 ## Genomic location **End position** 24537207 **Start position** 24494798 **Chromosome** 6 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000112294 **HGNC ID** HGNC:408 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:408) **NCBI Gene ID** 7915 **UniProt ID** P51649 ## Cellular location - Mitochondrion. - Mitochondria ## Tissue expression **Tissue specificity (tau)** 0.689489 **Expression inequality (Gini)** 0.436309 ### Highest expression Expression in transcripts per million **Brain - Frontal Cortex (BA9)** 46.73 **Brain - Nucleus accumbens (basal ganglia)** 45.91 **Brain - Anterior cingulate cortex (BA24)** 42.85 **Brain - Caudate (basal ganglia)** 39.44 **Brain - Cerebellar Hemisphere** 39.36 ### All tissues (54) Expression in transcripts per million - Brain - Frontal Cortex (BA9)46.73 - Brain - Nucleus accumbens (basal ganglia)45.91 - Brain - Anterior cingulate cortex (BA24)42.85 - Brain - Caudate (basal ganglia)39.44 - Brain - Cerebellar Hemisphere39.36 - Brain - Cortex38.25 - Brain - Hypothalamus37.29 - Brain - Cerebellum34.87 - Liver32.88 - Brain - Amygdala32.76 - Brain - Putamen (basal ganglia)27.97 - Brain - Substantia nigra25.12 - Brain - Hippocampus23.49 - Brain - Spinal cord (cervical c-1)20.38 - Cells - EBV-transformed lymphocytes18.05 - Vagina17.29 - Thyroid15.54 - Muscle - Skeletal15.05 - Nerve - Tibial13.59 - Pituitary12.3 - Ovary12.06 - Skin - Not Sun Exposed (Suprapubic)11.28 - Skin - Sun Exposed (Lower leg)11.08 - Testis10.68 - Prostate10.05 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0006540 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006540) - GO:0007417 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007417) - GO:0009450 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009450) ### Cellular components (2) - GO:0005739 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739) - GO:0005759 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005759) ### Molecular functions (2) - GO:0004777 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004777) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) ## Related records ### Trials (326) - A Comparison of Fluoxetine and Divalproex for the Treatment of Intermittent Explosive Disorder - A Comparison of Olanzapine in Combination With a Mood Stabilizer vs Mood Stabilizer Alone, in Mixed Bipolar Patients - A Comparison of Two Standard Therapies in the Management of Dementia With Agitation - A Comparison Study of the Efficacy and Tolerability of Depakote ER and Depakote DR - A Cross-sectional Study to Investigate the Effect of Topiramate on Bone and Mineral Metabolism in Female Participants With Epilepsy - A Dose Ranging Pilot Study for Intracerebroventricular (ICV) Delivery of Valproate in Subjects With Temporal Seizures - A Drug Interaction Study of Valproic Acid and Paliperidone Extended-Release (ER) in Patients With Schizophrenia, Bipolar I Disorder, or Schizoaffective Disorder - A Drug Interaction Study of Valproic Acid and Single-dose Paliperidone Extended-Release (ER) in Healthy Men - A Pharmacokinetic Study to Compare the Dosing of Valproic Acid in Subjects With Different Body Weights - A Phase II Study of Doxorubicin, Cyclophosphamide and Vindesine With Valproic Acid in Patients With Refractory or Relapsing Small Cell Lung Cancer After Platinum Derivatives and Etoposide - A Phase II Study of Epigenetic Therapy to Overcome Chemotherapy Resistance in Refractory Solid Tumors - A Phase II Trial of Valproic Acid in Patients With Advanced Thyroid Cancers of Follicular Cell Origin - A Phase III Open-Label, Multi-Center, Long-Term Extension Study of Depakote ER in Subjects Who Either Completed or Prematurely Discontinued Due to Ineffectiveness From Study M02-488. - A Study for the Treatment of Mania Associated With Bipolar I Disorder in Children and Adolescents - A Study for Treatment of Partial Seizures in Children - A Study in Stable Epilepsy Patients Comparing Brand and Generic Divalproex Sodium Extended Release Tablets - A Study of Divalproex Sodium in Children With ASD and Epileptiform EEG - A Study of Imatinib and Valproic Acid in Patients With Chronic Myelogenous Leukemia (CML) - A Study of the Effectiveness and Safety of Topiramate Compared With a Standard Therapy in Patients Newly Diagnosed With Epilepsy - A Study of the Effectiveness of Risk Minimization Measures Related to Depakine® (Sodium Valproate) in Saudi Arabia ### Drugs (4) - Divalproex sodium Succinate semialdehyde dehydrogenase inhibitor - Magnesium valproate Succinate semialdehyde dehydrogenase inhibitor - Valproate sodium Succinate semialdehyde dehydrogenase inhibitor - [Valproic acid](https://trialight.com/data/asset/valproic-acid-48e1faf9-d01e-4607-a2c6-6316492c15df.md) Succinate semialdehyde dehydrogenase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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