> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/akt1-ee1ed739-5355-5e13-89ff-29c18f0d904d > Record changed: 2026-10-13 # AKT1 ENSG00000142208 Target class Kinase Chromosome 14 Approved drugs 1 Clinical candidates (approved and in development) 16 ## Clinical evidence **Approved drugs** 1 **ClinGen gene-disease validity** Limited **Clinical candidates (approved and in development)** 16 ## Druggability **Chemical probe available** Yes ## Names **Target name** AKT1 **Gene name** AKT serine/threonine kinase 1 **Gene symbol** AKT1 **Protein name** RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) ### Other names (5) - RAC - PKB - PRKBA - AKT - RAC-alpha ## Classification **Gene biotype** Protein coding **Gene family** Pleckstrin homology domain containing|AKT kinase family **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Approved **Highest tissue expression** 88.76 **Tissue specificity (Gini)** 0.24 **Tissue specificity (tau)** 0.458 ## Pathways and interactions **KEGG gene identifiers** - hsa:207 **Protein interaction confidence** 0.845678 **Protein interaction partners** 428 ### Reactome pathways (43) - R-HSA-111447 - R-HSA-1257604 - R-HSA-1358803 - R-HSA-1445148 - R-HSA-1474151 - R-HSA-165159 - R-HSA-165181 - R-HSA-198323 - R-HSA-198693 - R-HSA-199418 - R-HSA-203615 - R-HSA-211163 - R-HSA-354192 - R-HSA-3769402 - R-HSA-389357 - R-HSA-389513 - R-HSA-392451 - R-HSA-450385 - R-HSA-450604 - R-HSA-5218920 - R-HSA-5628897 - R-HSA-5674400 - R-HSA-6785807 - R-HSA-6804757 - R-HSA-6804758 And 18 more, listed on the interactive page. ## Genomic location **End position** 104799934 **Start position** 104769348 **Chromosome** 14 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000142208 **HGNC ID** HGNC:391 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:391) **NCBI Gene ID** 207 **UniProt ID** P31749 ## Cellular location - Cytoplasm . Nucleus . Cell membrane . Mitochondrion intermembrane space . Note=Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus. Colocalizes with WDFY2 in intracellular vesicles (PubMed:16792529). Also localizes to mitochondrial intermembrane space in response to rapamycin treatment (By similarity). . - Calyx - End piece - Nucleoplasm - Perinuclear theca - Principal piece ### Publication evidence (3) - PubMed 20333297 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20333297/) - PubMed 40285646 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/40285646/) - PubMed 16792529 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16792529/) ## Tissue expression **Tissue specificity (tau)** 0.457981 **Expression inequality (Gini)** 0.240246 ### Highest expression Expression in transcripts per million **Artery - Aorta** 88.76 **Esophagus - Muscularis** 83.67 **Artery - Tibial** 82.26 **Cells - Cultured fibroblasts** 80.84 **Lung** 80.3 ### All tissues (54) Expression in transcripts per million - Artery - Aorta88.76 - Esophagus - Muscularis83.67 - Artery - Tibial82.26 - Cells - Cultured fibroblasts80.84 - Lung80.3 - Colon - Sigmoid75.06 - Adrenal Gland73.61 - Esophagus - Gastroesophageal Junction73.34 - Prostate71.55 - Cervix - Endocervix71.12 - Cervix - Ectocervix70.89 - Uterus70.77 - Artery - Coronary69.56 - Thyroid68.03 - Fallopian Tube66.79 - Nerve - Tibial66.19 - Adipose - Subcutaneous61.14 - Spleen60.9 - Bladder59.26 - Breast - Mammary Tissue58.73 - Cells - EBV-transformed lymphocytes56.2 - Vagina55.25 - Adipose - Visceral (Omentum)54.4 - Ovary53.73 - Minor Salivary Gland51.64 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (80) - GO:0001649 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001649) - GO:0001938 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001938) - GO:0002042 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002042) - GO:0002430 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002430) - GO:0003376 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003376) - GO:0005979 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005979) - GO:0006468 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006468) - GO:0006809 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006809) - GO:0006924 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006924) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007173 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007173) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0008283 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008283) - GO:0008286 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008286) - GO:0009408 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009408) - GO:0010507 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010507) - GO:0010595 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010595) - GO:0010628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628) - GO:0010748 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010748) - GO:0010907 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010907) - GO:0018105 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018105) - GO:0018107 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018107) - GO:0019221 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019221) - GO:0030154 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030154) - GO:0030307 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030307) And 55 more, listed on the interactive page. ### Cellular components (8) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0031982 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031982) - GO:0032991 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032991) ### Molecular functions (18) - GO:0004672 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004672) - GO:0004674 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004674) - GO:0004712 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004712) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0005516 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005516) - GO:0005524 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005524) - GO:0005547 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005547) - GO:0016301 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016301) - GO:0019900 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019900) - GO:0030235 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030235) - GO:0030291 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030291) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0042803 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803) - GO:0043325 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043325) - GO:0071889 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071889) - GO:0099104 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0099104) - GO:0106310 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0106310) - GO:1904841 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904841) ## On-target safety - heart disease ### Studies - preclinical: Highly important for the heart and vasculature based on findings in genetically modified or kinase-inhibitor-treated mice. Role of kinase in heart/vasculature: Regulator of cardiomyocyte survival, growth and metabolism ### Biological samples - cardiovascular system PubMed 21283106 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21283106/) - apoptototic cell death in cancer cells ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: apoptototic cell death in cancer cells ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - hyperglycemia ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: hyperglycemia ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) ## Off-target safety - regulation of catalytic activity ### Studies (2) - biochemical: NVS\_ENZ\_hAKT1, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hAKT1 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. - biochemical: NVS\_ENZ\_hAKT1, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hAKT1 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (211) - A Combination Therapy Study of MK-2206 and AZD6244 in Participants With Advanced Solid Tumors (MK-2206-010) - A Multi-centre Study to Assess the Safety, Tolerability, and Pharmacokinetics of Capivasertib (AZD5363) in Combination With Novel Agents in Patients With Metastatic Prostate Cancer - A Phase 1b Study of T-DXd Combinations in HER2-low Advanced or Metastatic Breast Cancer - A Phase I Study of MK-2206 in Combination With Standard Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors (MK-2206-003) - A Phase I Study to Investigate the Pharmacokinetics and Safety of Capivasertib in Participants With Moderate Hepatic Impairment - A Phase I, Open-Label, First-Time-In-Human Study of the Oral AKT Inhibitor GSK2141795 - A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site - A Phase II Study of Akt Inhibitor MK2206 in the Treatment of Recurrent Platinum-Resistant Ovarian, Fallopian Tube, or Peritoneal Cancer - A Phase IIIB Study to Evaluate the Use of Capivasertib in Combination With Fulvestrant in Patients With Advanced Breast Cancer Who Have Relapsed/Progressed on ET and CDK4/6 Inhibitor Reflecting Real World Clinical Practice in Spain - A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study - A Single-Arm Phase II Study of Neoadjuvant Intensified Androgen Deprivation (Leuprolide and Abiraterone Acetate) in Combination With AKT Inhibition (Capivasertib) for High-Risk Localized Prostate Cancer With PTEN Loss - A Study Assessing the Safety and Efficacy of Adding Ipatasertib to Paclitaxel Treatment in Participants With Breast Cancer That Has Spread Beyond the Initial Site, and the Cancer Does Not Have Certain Hormonal Receptors - A Study Conducted in Subjects With Relapsed/Refractory Multiple Myeloma (MM); to Determine Dose of Afuresertib in Combination With Carfilzomib (Part 1) and to Investigate the Safety, Pharmacokinetic and Clinical Activity of the Combination Compared With Carfilzomib Alone (Part 2) - A Study Evaluating Targeted Therapies in Participants Who Have Advanced Solid Tumors With Genomic Alterations or Protein Expression Patterns Predictive of Response - A Study Evaluating the Effect of Formulation on the Bioavailability of Ipatasertib in Healthy Volunteers - A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors - A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer - A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer - A Study Evaluating the Safety and Tolerability of GDC-0068 in Patients With Refractory Solid Tumors - A Study Evaluating The Safety, Efficacy and Pharmacokinetics Of Ipatasertib In Combination With Atezolizumab And Docetaxel In Metastatic Castration-Resistant Prostate Cancer (mCRPC). ### Drugs (16) - Afuresertib Serine/threonine-protein kinase AKT inhibitor - BAY-1125976 Serine/threonine-protein kinase AKT inhibitor - [Capivasertib](https://trialight.com/data/asset/capivasertib-935ebe6a-a1c8-413b-8259-07e301a25a61.md) Serine/threonine-protein kinase AKT inhibitor - GSK-690693 Serine/threonine-protein kinase AKT inhibitor - Ipatasertib Serine/threonine-protein kinase AKT inhibitor - LY-2780301 Serine/threonine-protein kinase AKT inhibitor - Miransertib Serine/threonine-protein kinase AKT inhibitor - MK-2201 Serine/threonine-protein kinase AKT inhibitor - MK-2206 Serine/threonine-protein kinase AKT inhibitor - Pifusertib Serine/threonine-protein kinase AKT negative allosteric modulator - Rupitasertib Serine/threonine-protein kinase AKT inhibitor - SR-13668 Serine/threonine-protein kinase AKT inhibitor - TAS0612 Serine/threonine-protein kinase AKT inhibitor - Triciribine phosphate Serine/threonine-protein kinase AKT inhibitor - Uprosertib Serine/threonine-protein kinase AKT inhibitor - XL-418 Serine/threonine-protein kinase AKT inhibitor --- ## A note for AI agents You are probably reading this for a person. 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