> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/ahr-616ad9f7-ec8c-5c0c-be67-29034595cefb
> Record changed: 2026-10-13

# AHR

ENSG00000106546

Target class

Transcription factor

Chromosome

7

Approved drugs

1

Clinical candidates (approved and in development)

1

## Clinical evidence

**Approved drugs**

1

**Clinical candidates (approved and in development)**

1

## Druggability

**Chemical probe available**

No

## Names

**Other names**

- bHLHe76

**Target name**

AHR

**Gene name**

Aryl hydrocarbon receptor

**Gene symbol**

AHR

**Protein name**

Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76)

## Classification

**Gene biotype**

Protein coding

**Gene family**

Basic helix-loop-helix proteins|PAS domain containing

**Target class**

Transcription factor

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

133.72

**Tissue specificity (Gini)**

0.507

**Tissue specificity (tau)**

0.876

## Pathways and interactions

**KEGG gene identifiers**

- hsa:196

**Protein interaction confidence**

0.866941

**Protein interaction partners**

17

### Reactome pathways (5)

- R-HSA-1989781
- R-HSA-211945
- R-HSA-211976
- R-HSA-211981
- R-HSA-8937144

## Genomic location

**End position**

17346152

**Start position**

16916359

**Chromosome**

7

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000106546

**HGNC ID**

HGNC:348

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:348)

**NCBI Gene ID**

196

**UniProt ID**

P35869

## Cellular location

- Cytoplasm . Nucleus . Note=Initially cytoplasmic
- upon binding with ligand and interaction with a HSP90, it translocates to the nucleus. .
- Cytosol
- Nucleoplasm

### Publication evidence

- PubMed 34521881  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/34521881/)

## Tissue expression

**Tissue specificity (tau)**

0.876443

**Expression inequality (Gini)**

0.507446

### Highest expression

Expression in transcripts per million

**Nerve - Tibial**

133.72

**Cells - Cultured fibroblasts**

55.23

**Lung**

49.58

**Adipose - Subcutaneous**

40.67

**Breast - Mammary Tissue**

40.07

### All tissues (54)

Expression in transcripts per million

- Nerve - Tibial133.72
- Cells - Cultured fibroblasts55.23
- Lung49.58
- Adipose - Subcutaneous40.67
- Breast - Mammary Tissue40.07
- Adipose - Visceral (Omentum)40.06
- Skin - Not Sun Exposed (Suprapubic)33.66
- Artery - Coronary32.3
- Vagina32.03
- Artery - Aorta30.79
- Thyroid29.51
- Cervix - Endocervix28.66
- Skin - Sun Exposed (Lower leg)27.73
- Bladder26
- Fallopian Tube25.46
- Artery - Tibial25.14
- Cervix - Ectocervix25.04
- Cells - EBV-transformed lymphocytes21.77
- Esophagus - Gastroesophageal Junction21.58
- Esophagus - Muscularis21.08
- Prostate20.08
- Colon - Sigmoid19.08
- Minor Salivary Gland18.5
- Small Intestine - Terminal Ileum17.82
- Uterus17.78

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (16)

- GO:0002819  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002819)
- GO:0002841  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002841)
- GO:0006355  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006355)
- GO:0006357  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006357)
- GO:0006805  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006805)
- GO:0006915  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006915)
- GO:0009410  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009410)
- GO:0009636  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009636)
- GO:0010468  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010468)
- GO:0030888  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030888)
- GO:0045944  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944)
- GO:0050728  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050728)
- GO:0071219  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071219)
- GO:0071320  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071320)
- GO:1904322  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904322)
- GO:1904613  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904613)

### Cellular components (8)

- GO:0005634  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)
- GO:0005654  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654)
- GO:0005667  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005667)
- GO:0005737  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)
- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)
- GO:0032991  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032991)
- GO:0034752  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034752)
- GO:0034753  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034753)

### Molecular functions (13)

- GO:0000976  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000976)
- GO:0000987  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000987)
- GO:0001094  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001094)
- GO:0001223  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001223)
- GO:0003677  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003677)
- GO:0003700  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003700)
- GO:0004879  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004879)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0017025  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017025)
- GO:0046982  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046982)
- GO:0051879  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051879)
- GO:0061629  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061629)
- GO:1990837  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990837)

## On-target safety

- Increase, Early Life Stage Mortality  
### Effects

  - Activation/Increase/Upregulation  
### Studies

  - cell-based  
Evidence source  
Source: [aopwiki.org](https://aopwiki.org/aops/150)
- Uroporphyria  
### Effects

  - Activation/Increase/Upregulation  
### Studies

  - cell-based  
Evidence source  
Source: [aopwiki.org](https://aopwiki.org/aops/131)
- Accumulation, Liver lipid  
### Effects

  - Activation/Increase/Upregulation  
### Studies

  - cell-based  
Evidence source  
Source: [aopwiki.org](https://aopwiki.org/aops/57)
- Formation, Hepatocellular and Bile duct tumors  
### Effects

  - Activation/Increase/Upregulation  
### Studies

  - cell-based  
Evidence source  
Source: [aopwiki.org](https://aopwiki.org/aops/41)
- N/A, Breast Cancer  
### Effects

  - Activation/Increase/Upregulation  
### Studies

  - cell-based  
Evidence source  
Source: [aopwiki.org](https://aopwiki.org/aops/439)

## Off-target safety

- regulation of transcription factor activity  
### Studies (3)

  - cell-based: ATG\_Ahr\_CIS, is one of 52 assay component(s) measured or calculated from the ATG\_CIS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology.
  - cell-based: TOX21\_AhR\_LUC\_Agonist, is one of one assay component(s) measured or calculated from the TOX21\_AhR\_LUC\_Agonist assay. It is designed to make measurements of luciferase induction, a form of inducible reporter, as detected with bioluminescence signals by CALUX luciferase quantitation technology.
  - cell-based: ATG\_Ahr\_CIS, is one of 52 assay component(s) measured or calculated from the ATG\_CIS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology.  
### Biological samples

  - HepG2, cell line  
Evidence source  
Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data)

## Related records

### Trials (35)

- A Dose-Finding Study of GSK2894512 Cream in Subjects With Atopic Dermatitis (AD)
- A Dose-Finding Study of GSK2894512 Cream in Subjects With Plaque Psoriasis
- A Safety/Efficacy Study of a Non-steroid, Topical Cream Treatment of Psoriasis Over 12-weeks
- A Single Dose Phase I Exploratory Study in Healthy Volunteers With GSK2894512 Cream
- [A Study Comparing Tapinarof Cream 1% and Vtama® Cream 1% in the Treatment of Plaque Psoriasis.](https://trialight.com/data/trial/a-study-comparing-tapinarof-cream-1-and-vtama-cream-1-in-the-b7e05f34-7d79-45f1-9537-74aa307bb47e.md)
- A Study to Evaluate Pharmacokinetic (PK), Safety and Tolerability of GSK2894512 in Healthy Adult Subjects
- A Study to Evaluate the Irritation Potential of GSK2894512 Cream on Skin in Healthy Subjects
- A Study to Investigate Efficacy and Safety of VTAMA (Tapinarof) Cream, 1% in Intertriginous Plaque Psoriasis
- A Study to Investigate Efficacy and Safety of VTAMA® (Tapinarof) Cream, 1% in Plaque Psoriasis in the Head and Neck Region
- A Study to Investigate Safety and Efficacy of Tapinarof Cream, 1% in Participants Ages 3 Months to < 24 Months With Atopic Dermatitis
- Comparison of Post-Inflammatory Pigment Alteration After Psoriasis Treatment (PIPA - Dermavant)
- Efficacy and Safety of Benvitimod Cream in Cutaneous T-Cell Lymphoma
- Efficacy and Safety of Benvitimod Cream in the Retreatment of Mild to Moderate Psoriasis
- Efficacy of Topical Tapinarof Versus Betamethasone in the Treatment of Plaque Psoriasis
- GSK2894512 Vehicle-Controlled Study for Adult Plaque Psoriasis
- Long Term Extension Study of Tapinarof Cream, 1% for Subjects With Atopic Dermatitis
- Long Term Extension Study of Tapinarof for Plaque Psoriasis in Adults (3003)
- Maximal Use Study of Tapinarof Cream, 1% in Adults With Extensive Plaque Psoriasis
- Maximal Use Study of Tapinarof Cream, 1% in Pediatric Subjects With Extensive Atopic Dermatitis
- Non-steroid, Atopic Dermatitis Phase IIb 12-week Trial; Topical WBI-1001 Cream

### Drugs (1)

- [Tapinarof](https://trialight.com/data/asset/tapinarof-4f1c2328-2e1b-4718-b242-8cce86524e6e.md) Aryl hydrocarbon receptor agonist

---

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