> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/agtr2-52b21d80-20f4-5e0a-a903-46ed7b9c5943
> Record changed: 2026-11-04

# AGTR2

ENSG00000180772

Target class

GPCR

Chromosome

X

Approved drugs

0

Clinical candidates (approved and in development)

1

## Clinical evidence

**Approved drugs**

0

**ClinGen gene-disease validity**

Disputed

**Clinical candidates (approved and in development)**

1

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

AGTR2

**Gene name**

Angiotensin II receptor type 2

**Gene symbol**

AGTR2

**Protein name**

Type-2 angiotensin II receptor (Angiotensin II type-2 receptor) (AT2 receptor)

### Other names (2)

- AT2
- MRX88

## Classification

**Gene biotype**

Protein coding

**Gene family**

Angiotensin receptors

**Target class**

GPCR

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

2

**Highest tissue expression**

1.18

**Tissue specificity (Gini)**

0.862

**Tissue specificity (tau)**

0.935

## Pathways and interactions

**KEGG gene identifiers**

- hsa:186

**Protein interaction confidence**

0.8835

**Protein interaction partners**

12

### Reactome pathways (2)

- R-HSA-375276
- R-HSA-418594

## Genomic location

**End position**

116174974

**Start position**

116170744

**Chromosome**

X

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000180772

**HGNC ID**

HGNC:338

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:338)

**NCBI Gene ID**

186

**UniProt ID**

P50052

## Cellular location

- Cell membrane
- Multi-pass membrane protein .

### Publication evidence (4)

- PubMed 28379944  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28379944/)
- PubMed 29967536  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/29967536/)
- PubMed 31899086  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/31899086/)
- PubMed 32669569  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/32669569/)

## Tissue expression

**Tissue specificity (tau)**

0.934762

**Expression inequality (Gini)**

0.861569

### Highest expression

Expression in transcripts per million

**Cervix - Endocervix**

1.18

**Lung**

1.12

**Fallopian Tube**

0.84

**Brain - Cerebellum**

0.46

**Uterus**

0.38

### All tissues (54)

Expression in transcripts per million

- Cervix - Endocervix1.18
- Lung1.12
- Fallopian Tube0.84
- Brain - Cerebellum0.46
- Uterus0.38
- Cervix - Ectocervix0.21
- Heart - Atrial Appendage0.19
- Colon - Sigmoid0.15
- Artery - Aorta0.15
- Adrenal Gland0.12
- Brain - Cerebellar Hemisphere0.11
- Artery - Coronary0.07
- Pancreas0.06
- Heart - Left Ventricle0.06
- Cells - EBV-transformed lymphocytes0.05
- Adipose - Visceral (Omentum)0.05
- Colon - Transverse0.03
- Kidney - Medulla0.03
- Nerve - Tibial0
- Vagina0
- Cells - Cultured fibroblasts0
- Testis0
- Stomach0
- Bladder0
- Pituitary0

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (9)

- GO:0001974  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001974)
- GO:0007166  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007166)
- GO:0007186  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186)
- GO:0008217  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008217)
- GO:0030308  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030308)
- GO:0038060  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038060)
- GO:0042311  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042311)
- GO:0051387  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051387)
- GO:2001238  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2001238)

### Cellular components

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)

### Molecular functions (3)

- GO:0004945  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004945)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0048019  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048019)

## On-target safety

- decreased pain  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased pain  
### Biological samples

  - renal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- hypocalvaria  
### Effects

  - Inhibition/Decrease/Downregulation: developmental toxicity  
### Studies

  - preclinical: hypocalvaria  
### Biological samples

  - renal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- oligoamnios  
### Effects

  - Inhibition/Decrease/Downregulation: developmental toxicity  
### Studies

  - preclinical: oligoamnios  
### Biological samples

  - renal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased urine excretion  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased urine excretion  
### Biological samples

  - renal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased blood pressure  
### Effects

  - Inhibition/Decrease/Downregulation: developmental toxicity  
### Studies

  - preclinical: decreased blood pressure  
### Biological samples

  - renal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- pulmonary hypoplasia  
### Effects

  - Inhibition/Decrease/Downregulation: developmental toxicity  
### Studies

  - preclinical: pulmonary hypoplasia  
### Biological samples

  - renal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- respiratory distress syndrome  
### Effects

  - Inhibition/Decrease/Downregulation: developmental toxicity  
### Studies

  - preclinical: respiratory distress syndrome  
### Biological samples

  - renal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- intrauterine growth retardation  
### Effects

  - Inhibition/Decrease/Downregulation: developmental toxicity  
### Studies

  - preclinical: intrauterine growth retardation  
### Biological samples

  - renal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- death  
### Effects

  - Inhibition/Decrease/Downregulation: developmental toxicity  
### Studies

  - preclinical: death  
### Biological samples

  - renal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased urinary sodium excretion  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased urinary sodium excretion  
### Biological samples

  - renal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- cerebral complications  
### Effects

  - Inhibition/Decrease/Downregulation: developmental toxicity  
### Studies

  - preclinical: cerebral complications  
### Biological samples

  - renal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- limb defects  
### Effects

  - Inhibition/Decrease/Downregulation: developmental toxicity  
### Studies

  - preclinical: limb defects  
### Biological samples

  - renal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- persistent patent ductus arteriosus  
### Effects

  - Inhibition/Decrease/Downregulation: developmental toxicity  
### Studies

  - preclinical: persistent patent ductus arteriosus  
### Biological samples

  - renal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- renal failure  
### Effects

  - Inhibition/Decrease/Downregulation: developmental toxicity  
### Studies

  - preclinical: renal failure  
### Biological samples

  - renal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)

## Related records

### Trials (86)

- : Vascular Function in Health and Disease
- A Phase 1 Study of LJPC-501 in Patients With Hepatorenal Syndrome
- A Phase 3 Study of LJPC-501 in Patients With Catecholamine-Resistant Hypotension
- A Study of LJPC-501 in Paediatric Patients With Hypotension Associated With Distributive or Vasodilatory Shock
- A Study of LJPC-501 in Pediatric Patients With Hypotension
- [A Trial to Evaluate Efficacy and Safety of Buloxibutid in People With Idiopathic Pulmonary Fibrosis.](https://trialight.com/data/trial/a-trial-to-evaluate-efficacy-and-safety-of-buloxibutid-in-8242d8e6-1eb0-4402-84a0-ed9db8324a63.md)
- A Trial to Evaluate the Effect of C21 on Endothelial Dysfunction in Subjects With Type 2 Diabetes
- A Trial to Investigate Recovery From COVID-19 With C21 in Adult Subjects
- Acceleration of Platelet Recovery Following Autologous Peripheral Blood Stem Cell Transplant (PBSC) in Hodgkin, Non-Hodgkin Lymphoma or Multiple Myeloma Patients
- Acute Effect of Agiotensin-(1-7) in Healthy and Hypertensive Subjects
- ANG-First Trial (Angiotensin II as First-Line Vasopressor Therapy in Cardiac Surgery)
- Angiotensin (1-7) for the Treatment of COVID-19 in Hospitalized Patients
- Angiotensin (1-7) Treatment to Improve Cognitive Functioning in Heart Failure Patients
- Angiotensin 1-7 as a Therapy in the Treatment of COVID-19
- Angiotensin 1-7 in Obesity Hypertension
- Angiotensin 2 for AKI After OLT
- Angiotensin 2 for Hepatorenal Syndrome
- Angiotensin II for Distributive Shock
- Angiotensin II for Septic Shock Treatment
- Angiotensin II in General Anesthesia

### Drugs (4)

- Angiotensin II
- [Buloxibutid](https://trialight.com/data/asset/buloxibutid-159891e9-bf22-46f4-8684-d6908d9b646b.md)
- Olodanrigan Angiotensin II type 2 (AT-2) receptor antagonist
- Talfirastide

---

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