> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/agtr1-c59c8e57-b1b7-5c8f-a953-a2b3d70939ed > Record changed: 2026-10-13 # AGTR1 ENSG00000144891 Target class GPCR Chromosome 3 Approved drugs 12 Clinical candidates (approved and in development) 19 ## Clinical evidence **Approved drugs** 12 **Clinical candidates (approved and in development)** 19 ## Druggability **Chemical probe available** No ## Names **Target name** AGTR1 **Gene name** Angiotensin II receptor type 1 **Gene symbol** AGTR1 **Previous gene symbols** - AGTR1B **Protein name** Type-1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type-1 receptor) (AT1 receptor) ### Other names (9) - AT1 - AT2R1 - AGTR1A - AT2R1A - HAT1R - AG2S - AT2R1B - AT1B - ATR1 ## Classification **Gene biotype** Protein coding **Gene family** Angiotensin receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 39 **Protein localisation evidence grade** Uncertain **Highest tissue expression** 70.24 **Tissue specificity (Gini)** 0.644 **Tissue specificity (tau)** 0.897 ## Pathways and interactions **KEGG gene identifiers** - hsa:185 **Protein interaction confidence** 0.839674 **Protein interaction partners** 46 ### Reactome pathways (4) - R-HSA-375276 - R-HSA-416476 - R-HSA-8856825 - R-HSA-8856828 ## Genomic location **End position** 148743045 **Start position** 148697784 **Chromosome** 3 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000144891 **HGNC ID** HGNC:336 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:336) **NCBI Gene ID** 185 **UniProt ID** P30556 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (5) - PubMed 33713620 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/33713620/) - PubMed 25913193 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25913193/) - PubMed 26420482 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26420482/) - PubMed 30639100 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30639100/) - PubMed 32079768 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/32079768/) ## Tissue expression **Tissue specificity (tau)** 0.896992 **Expression inequality (Gini)** 0.644408 ### Highest expression Expression in transcripts per million **Adipose - Subcutaneous** 70.24 **Breast - Mammary Tissue** 39 **Adipose - Visceral (Omentum)** 34.33 **Adrenal Gland** 33.7 **Liver** 27.97 ### All tissues (54) Expression in transcripts per million - Adipose - Subcutaneous70.24 - Breast - Mammary Tissue39 - Adipose - Visceral (Omentum)34.33 - Adrenal Gland33.7 - Liver27.97 - Colon - Sigmoid23.62 - Thyroid18.13 - Bladder15.36 - Skin - Sun Exposed (Lower leg)14.4 - Artery - Tibial13.57 - Lung12.96 - Nerve - Tibial12.37 - Fallopian Tube11.01 - Esophagus - Gastroesophageal Junction10.84 - Esophagus - Muscularis8.86 - Artery - Coronary8.74 - Colon - Transverse7.6 - Skin - Not Sun Exposed (Suprapubic)6.79 - Heart - Atrial Appendage5.87 - Cells - Cultured fibroblasts5.57 - Kidney - Cortex5.55 - Uterus5.5 - Artery - Aorta5.45 - Spleen5.37 - Kidney - Medulla5.07 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (20) - GO:0001822 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001822) - GO:0002034 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002034) - GO:0003081 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003081) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0007200 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007200) - GO:0007204 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007204) - GO:0007266 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007266) - GO:0010744 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010744) - GO:0019229 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019229) - GO:0019722 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019722) - GO:0038166 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038166) - GO:0046718 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046718) - GO:0050727 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050727) - GO:0050729 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050729) - GO:0060326 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060326) - GO:0086097 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086097) - GO:0090205 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090205) - GO:0097746 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097746) - GO:1903589 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903589) - GO:2000379 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000379) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (5) - GO:0001596 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001596) - GO:0004945 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004945) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0031711 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031711) - GO:0046982 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046982) ## On-target safety - increased pain ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased pain ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - respiratory distress syndrome ### Effects - Inhibition/Decrease/Downregulation: developmental toxicity ### Studies - preclinical: respiratory distress syndrome ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - excessive thirst ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: excessive thirst ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - dry mouth ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: dry mouth ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - hypocalvaria ### Effects - Inhibition/Decrease/Downregulation: developmental toxicity ### Studies - preclinical: hypocalvaria ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - oligoamnios ### Effects - Inhibition/Decrease/Downregulation: developmental toxicity ### Studies - preclinical: oligoamnios ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - cerebral complications ### Effects - Inhibition/Decrease/Downregulation: developmental toxicity ### Studies - preclinical: cerebral complications ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - slow or irregular heartbeat ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: slow or irregular heartbeat ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - cell proliferation and migration ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: cell proliferation and migration ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - persistent patent ductus arteriosus ### Effects - Inhibition/Decrease/Downregulation: developmental toxicity ### Studies - preclinical: persistent patent ductus arteriosus ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - renal failure ### Effects - Inhibition/Decrease/Downregulation: developmental toxicity ### Studies - preclinical: renal failure ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased/decreased urine excretion ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased/decreased urine excretion ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - antihypertensive and cardioprotective agent ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: antihypertensive and cardioprotective agent ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - increased blood pressure ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased blood pressure ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - positive inotropy ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: positive inotropy ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - decreased blood pressure ### Effects (2) - Inhibition/Decrease/Downregulation: developmental toxicity - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased blood pressure ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased pain ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased pain ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - hypotension ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: hypotension ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - dizziness ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: dizziness ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - pulmonary hypoplasia ### Effects - Inhibition/Decrease/Downregulation: developmental toxicity ### Studies - preclinical: pulmonary hypoplasia ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - intrauterine growth retardation ### Effects - Inhibition/Decrease/Downregulation: developmental toxicity ### Studies - preclinical: intrauterine growth retardation ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased/decreased urinary sodium excretion ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased/decreased urinary sodium excretion ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased urinary sodium excretion ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased urinary sodium excretion ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - death ### Effects - Inhibition/Decrease/Downregulation: developmental toxicity ### Studies - preclinical: death ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - vasocontriction ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: vasocontriction ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) And 1 more, listed on the interactive page. ## Off-target safety - receptor binding ### Studies - biochemical: NVS\_GPCR\_hAT1, is one of one assay component(s) measured or calculated from the NVS\_GPCR\_hAT1 assay. It is designed to make measurements of radioligand binding, a form of binding reporter, as detected with scintillation counting signals by Filter-based radiodetection technology. ### Biological samples - brain, tissue-based cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (1,514) - : Vascular Function in Health and Disease - " Evaluation of Safety and Efficacy of Empagliflozin and Sacubitril/Valsartan for CHF With Reduced Ejection Fraction in ACHD " - 1 Year Trial Telmisartan 80 mg Versus Valsartan 160 mg in Hypertensive Type 2 Diabetic Patients With Overt Nephropathy - 18 Week Study Evaluating Safety and Efficacy of Olmesartan, Amlodipine, and Hydrochlorothiazide, in Type 2 Diabetics - 24 Hour Ambulatory Cardiac Oxygen Consumption - 3 x 3 Factorial Trial of Telmisartan and Hydrochlorothiazide in Patients With Essential Hypertension - 8 Weeks Study to Evaluate the Efficacy and Safety of Valsartan in Combination With Aliskiren Compared to Valsartan Alone in Patients With Stage 2 Hypertension - 8-week Study to Evaluate Safety and Efficacy of Various Combinations of Valsartan, HCTZ, and Amlodipine in Patients With Moderate to Severe Hypertension - A 10-12 Week Study to Evaluate the Safety and Efficacy of 320 mg Valsartan and 80 mg Simvastatin in Combination and as Monotherapies in Treating Hypertension and Hypercholesterolemia - A 16 Week Study to Evaluate the Effect on Insulin Sensitivity of Valsartan (320 mg) and Hydrochlorothiazide (25 mg) Combined and Alone, in Patients With Metabolic Syndrome - A 52 Week Study to Evaluate the Effects of Losartan With or Without HCTZ on Plasma Glucose, Metabolic Parameters, Blood Pressure in Hypertensive Patients With Metabolic Syndrome (0954A-331) - A Bioequivalence Study Between Telmione 80 mg and Micardis 80 mg in Healthy Adult Volunteers - A Bioequivalence Study Between Telmione Plus 80/12.5mg and Micardis Plus 80/12.5 mg in Healthy Adult Volunteers - A Bioequivalence Study Comparing Cilnidipine/Valsartan Combination Tablet With Coadministration of Cilnidipine and Valsartan - A Bioequivalence Study Comparing Cilnidipine/Valsartan Combination With Coadministration of Cilnidipine and Valsartan - A Bioequivalence Study Comparing Irbesartan/Atorvastatin Combination Tablet With Coadministration of Irbesartan and Atorvastatin - A Bioequivalence Study of Amlodipine / Valsartan From Amlodipine/Valsartan 10/160 Tablets (Pharmacare, Palestine) and Exforge Tablets (Novartis Pharma, USA) - A Bioequivalence Study of Amlodipine Plus Losartan Versus Amlodipine and Losartan - A Bioequivalence Study of Amlodipine Plus Losartan Versus Amlodipine and Losartan - A Bioequivalence Study of Losartan Potassium Tablets (Containing Losartan Potassium 100 mg) in Normal, Healthy, Adults Under Fasting Conditions ### Drugs (24) - Angiotensin II Type-1 angiotensin II receptor agonist - Angiotensin II acetate Type-1 angiotensin II receptor agonist - Azilsartan Type-1 angiotensin II receptor antagonist - Azilsartan kamedoxomil Type-1 angiotensin II receptor antagonist - Azilsartan medoxomil Type-1 angiotensin II receptor antagonist - Candesartan Type-1 angiotensin II receptor antagonist - Candesartan cilexetil Type-1 angiotensin II receptor antagonist - Eprosartan Type-1 angiotensin II receptor antagonist - Eprosartan mesylate Type-1 angiotensin II receptor antagonist - Fimasartan Type-1 angiotensin II receptor antagonist - Irbesartan Type-1 angiotensin II receptor antagonist - Irbesartan hydrochloride Type-1 angiotensin II receptor antagonist - Losartan Type-1 angiotensin II receptor antagonist - Losartan potassium Type-1 angiotensin II receptor antagonist - [Olmesartan](https://trialight.com/data/asset/olmesartan-f08e3b2e-f2f4-481f-b3c2-298612dfb4b3.md) Type-1 angiotensin II receptor antagonist - Olmesartan medoxomil Type-1 angiotensin II receptor antagonist - Pratosartan Type-1 angiotensin II receptor antagonist - Saralasin Type-1 angiotensin II receptor antagonist - Saralasin acetate Type-1 angiotensin II receptor antagonist - Sparsentan Type-1 angiotensin II receptor antagonist --- ## A note for AI agents You are probably reading this for a person. 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