> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/adrm1-21aacba2-e414-54a6-9f55-4bf543c44c62 > Record changed: 2026-10-13 # ADRM1 ENSG00000130706 Target class Unclassified protein Chromosome 20 Approved drugs 3 Clinical candidates (approved and in development) 5 ## Clinical evidence **Approved drugs** 3 **Clinical candidates (approved and in development)** 5 ## Druggability **Chemical probe available** No ## Names **Target name** ADRM1 **Gene name** ADRM1 26S proteasome ubiquitin receptor **Gene symbol** ADRM1 **Protein name** Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog) ### Other names (4) - GP110 - Rpn13 - ARM1 - PSMD16 ## Classification **Gene biotype** Protein coding **Gene family** Proteasome **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 175.91 **Tissue specificity (Gini)** 0.225 **Tissue specificity (tau)** 0.628 ## Pathways and interactions **KEGG gene identifiers** - hsa:11047 **Protein interaction confidence** 0.913628 **Protein interaction partners** 78 ### Reactome pathways (67) - R-HSA-1169091 - R-HSA-1234176 - R-HSA-1236974 - R-HSA-1236978 - R-HSA-174084 - R-HSA-174113 - R-HSA-174154 - R-HSA-174178 - R-HSA-174184 - R-HSA-180534 - R-HSA-180585 - R-HSA-187577 - R-HSA-195253 - R-HSA-202424 - R-HSA-211733 - R-HSA-2467813 - R-HSA-2871837 - R-HSA-349425 - R-HSA-350562 - R-HSA-382556 - R-HSA-450408 - R-HSA-4608870 - R-HSA-4641257 - R-HSA-4641258 - R-HSA-5358346 And 42 more, listed on the interactive page. ## Genomic location **End position** 62308867 **Start position** 62302066 **Chromosome** 20 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000130706 **HGNC ID** HGNC:15759 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:15759) **NCBI Gene ID** 11047 **UniProt ID** Q16186 ## Cellular location - Cytoplasm . Nucleus . - Cytosol - Nucleoplasm ### Publication evidence - PubMed 16990800 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16990800/) ## Tissue expression **Tissue specificity (tau)** 0.627869 **Expression inequality (Gini)** 0.225078 ### Highest expression Expression in transcripts per million **Testis** 175.91 **Muscle - Skeletal** 163.15 **Brain - Cerebellar Hemisphere** 107.48 **Brain - Cerebellum** 102.24 **Artery - Tibial** 94.32 ### All tissues (54) Expression in transcripts per million - Testis175.91 - Muscle - Skeletal163.15 - Brain - Cerebellar Hemisphere107.48 - Brain - Cerebellum102.24 - Artery - Tibial94.32 - Skin - Sun Exposed (Lower leg)91.25 - Uterus88.92 - Cells - Cultured fibroblasts86.82 - Artery - Coronary85.08 - Cells - EBV-transformed lymphocytes84.91 - Esophagus - Muscularis84.84 - Spleen84.47 - Artery - Aorta84.36 - Lung82.56 - Esophagus - Gastroesophageal Junction82.45 - Skin - Not Sun Exposed (Suprapubic)82.23 - Colon - Sigmoid81.42 - Esophagus - Mucosa80.77 - Fallopian Tube79.89 - Adipose - Subcutaneous78.87 - Nerve - Tibial78.77 - Bladder77.17 - Adrenal Gland74.26 - Vagina73.44 - Breast - Mammary Tissue69.05 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0006368 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006368) - GO:0043248 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043248) ### Cellular components (5) - GO:0000502 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000502) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) ### Molecular functions (5) - GO:0002020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002020) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0061133 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061133) - GO:0070628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070628) - GO:0140678 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140678) ## Related records ### Trials (789) - 2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy - 3D PET Myocardial Blood Flow and Rb82 Infusion Profiles - 4SCAR-T Therapy Post CD19-targeted Immunotherapy - A Basket Study of CTA313 in Participants With Active Autoimmune Diseases - A Clinical Research About CD70-targeted CAR-NKT Cells Therapy Advanced Malignant Solid Tumors - A Clinical Study Evaluating the Safety and Efficacy of BCMA-GPRC5D CAR-T in Patients With Relapsed/Refractory Multiple Myeloma Who Have Received Three or More Lines of Treatment - A Clinical Study of BioTTT001 in Combination With SOX and Toripalimab in Patients With Gastric Cancer - A Clinical Study of BioTTT001 in Combination With Toripalimab and Regorafenib in Patients With Colorectal Cancer - A Clinical Study of CD19 CAR-T in Active Systemic Lupus Erythematosus - A Clinical Study of CEA-targeted CAR-T in the Treatment of CEA-positive Advanced Malignant Solid Tumors - A Clinical Study of T3011 in Combination With Toripalimab and Regorafenib in Patients With Colorectal Cancer - A Clinical Study on the Safety, Tolerance, and Preliminary Efficacy of γδ-T Cell Injection in the Treatment of Advanced Bladder Cancer - A Clinical Trial of Four Medicines (Elranatamab Plus Carfilzomib and Dexamethasone or Maplirpacept) in People With Relapsed Refractory Multiple Myeloma - A Clinical Trial to Learn About the Study Medicine Called Maplirpacept (PF-07901801), Alone and When Used in Combination With Other Medicines to Treat Participants With Advanced Hematological Malignancies, Including Lymphoma, Leukemia and Multiple Myeloma - A Dose Escalation Study of Carfilzomib Taken With Thalidomide and Dexamethasone in Relapsed AL Amyloidosis - A First in Human Study to Evaluate the Safety of Infusion of MNV-BM-PLC (Autologous CD34+ Cells Enriched With Placenta Derived Allogeneic Mitochondria) in Patients With Primary Mitochondrial Diseases Associated With Mitochondrial DNA Mutation or Deletion - A Hypoxia-Inducible CAR-T Cell Targeting AXL and CD73 for Advanced Gastric Cancer - A Multi-center Open-label Phase 2 Study of Ixazomib, Iberdomide and Dexamethasone in Elderly Patients With Multiple Myeloma at First Relapse." - A Multi-cohort Study of Safety, Efficacy, PK and PD of GNR-055 in Patients With Mucopolysaccharidosis Type II - A Multi-site Study of Autologous Cord Blood Cells for Hypoxic Ischemic Encephalopathy ### Drugs (5) - Bortezomib D-mannitol 26S proteasome inhibitor - [Carfilzomib](https://trialight.com/data/asset/carfilzomib-42f49602-1f34-4e14-b345-79d6fd69324f.md) 26S proteasome inhibitor - Ixazomib 26S proteasome inhibitor - Ixazomib citrate 26S proteasome inhibitor - Oprozomib 26S proteasome inhibitor --- ## A note for AI agents You are probably reading this for a person. 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