> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/adrb3-61a0c2dc-6d50-5bea-b1a9-be13f4623617 > Record changed: 2026-11-04 # ADRB3 ENSG00000188778 Target class GPCR Chromosome 8 Approved drugs 18 Clinical candidates (approved and in development) 23 ## Clinical evidence **Approved drugs** 18 **Clinical candidates (approved and in development)** 23 ## Druggability **Chemical probe available** Yes ## Names **Target name** ADRB3 **Gene name** Adrenoceptor beta 3 **Gene symbol** ADRB3 **Protein name** Beta-3 adrenergic receptor (Beta-3 adrenoreceptor) (Beta-3 adrenoceptor) ## Classification **Gene biotype** Protein coding **Gene family** Adrenoceptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 7 **Protein localisation evidence grade** Uncertain **Highest tissue expression** 24.87 **Tissue specificity (Gini)** 0.891 **Tissue specificity (tau)** 0.969 ## Pathways and interactions **KEGG gene identifiers** - hsa:155 **Protein interaction confidence** 0.828556 **Protein interaction partners** 18 ### Reactome pathways (2) - R-HSA-390696 - R-HSA-418555 ## Genomic location **End position** 37966599 **Start position** 37962990 **Chromosome** 8 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000188778 **HGNC ID** HGNC:288 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:288) **NCBI Gene ID** 155 **UniProt ID** P13945 ## Cellular location - Cell membrane - Multi-pass membrane protein . ## Tissue expression **Tissue specificity (tau)** 0.969077 **Expression inequality (Gini)** 0.890737 ### Highest expression Expression in transcripts per million **Ovary** 24.87 **Bladder** 10.47 **Esophagus - Muscularis** 7.86 **Fallopian Tube** 7.77 **Esophagus - Gastroesophageal Junction** 4.82 ### All tissues (54) Expression in transcripts per million - Ovary24.87 - Bladder10.47 - Esophagus - Muscularis7.86 - Fallopian Tube7.77 - Esophagus - Gastroesophageal Junction4.82 - Colon - Sigmoid3.25 - Colon - Transverse1.12 - Uterus0.99 - Cervix - Endocervix0.82 - Prostate0.58 - Stomach0.52 - Small Intestine - Terminal Ileum0.36 - Cervix - Ectocervix0.29 - Vagina0.23 - Adipose - Visceral (Omentum)0.19 - Brain - Cortex0.18 - Esophagus - Mucosa0.17 - Brain - Frontal Cortex (BA9)0.12 - Lung0.12 - Kidney - Medulla0.11 - Testis0.1 - Brain - Anterior cingulate cortex (BA24)0.09 - Brain - Amygdala0.09 - Breast - Mammary Tissue0.08 - Adipose - Subcutaneous0.06 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (14) - GO:0005975 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005975) - GO:0006091 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006091) - GO:0006112 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006112) - GO:0006898 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006898) - GO:0007187 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007187) - GO:0007188 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007188) - GO:0007193 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007193) - GO:0043410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410) - GO:0045744 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045744) - GO:0045986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045986) - GO:0055118 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055118) - GO:0070374 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070374) - GO:0071880 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071880) - GO:0071881 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071881) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0043235 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235) ### Molecular functions (6) - GO:0003925 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003925) - GO:0004939 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004939) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0015052 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015052) - GO:0042803 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803) - GO:0051380 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051380) ## Off-target safety - receptor binding ### Studies - biochemical: NVS\_GPCR\_hAdrb3, is one of one assay component(s) measured or calculated from the NVS\_GPCR\_hAdrb3 assay. It is designed to make measurements of radioligand binding, a form of binding reporter, as detected with scintillation counting signals by Filter-based radiodetection technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (3,006) - : Vascular Function in Health and Disease - ''Efficacy of Propranolol in the Treatment of Infantile Hemangioma" - "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat - "The Effect Of Subcutaneous Epinephrine Dosage On Blood Loss In Surgical Incision" - "The Evaluation of Stimulant Withdrawal" - 10 Vs.15 mcg Norepinephrine Bolus in Severe Maternal Hypotension During Cesarean Delivery - 12-week Efficacy of Indacaterol - 12-week Open-label Evaluation of Efficacy and Safety of Indacaterol - 129-Xe MRI Study of Single Triple Therapy Inhaler Effects in COPD Patients With Moderate-severe Dyspnea and/or Poor Health Status With High or Low Risk of Exacerbation - 24 Hour Ambulatory Cardiac Oxygen Consumption - 24-hour Control of Intraocular Pressure (IOP) in Ocular Hypertension - 24-hour Efficacy and Ocular Surface With Talfuprost and Triple Combined Therapy - 24-hour Efficacy and Tolerability of the Tafluprost-timolol Fixed Association Without Preservatives in Glaucomatous or Ocular Hypertensive Patients Already Treated With Latanoprost Preserved With BAK. A Prospective, Open Study of 3 Months Duration. - 24-Hour Intraocular Pressure (IOP) And Blood Pressure Control In Glaucoma And Ocular Hypertension Patients - 24-Hour Intraocular Pressure (IOP) Control With Travoprost/Timolol Fixed Combination - 24-Hour Intraocular Pressure Control With Bimatoprost/Timolol Versus Latanoprost as First Choice - 24-hour Intraocular Pressure Control With Travoprost/Timolol Fixed Combination Versus Travoprost - 24-hour Study of Dorzolamide/Timolol and Latanoprost/Timolol Fixed Combinations - 24-week Trial Comparing GSK573719/GW642444 With GW642444 and With Tiotropium in Chronic Obstructive Pulmonary Disease - 26 Week Efficacy, Safety and Tolerability Study of Indacaterol in Patients With Chronic Obstructive Pulmonary Disease (COPD) ### Drugs (72) - Abediterol - Acebutolol - [Albuterol](https://trialight.com/data/asset/albuterol-69b7004f-4bd0-483d-811f-f958009ba32f.md) - Alprenolol - Amibegron Beta-3 adrenergic receptor agonist - Amibegron hydrochloride Beta-3 adrenergic receptor agonist - Atenolol - Betaxolol - Bisoprolol - Bucindolol - Bunolol - Bupranolol - Carazolol - Carteolol Adrenergic receptor beta antagonist - Carteolol hydrochloride Adrenergic receptor beta antagonist - Carvedilol Adrenergic receptor beta antagonist - Carvedilol phosphate Adrenergic receptor beta antagonist - Cimaterol - Clenbuterol - Denopamine --- ## A note for AI agents You are probably reading this for a person. 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