> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/adrb2-dd50b672-19f0-5015-be62-c6f5861dc510
> Record changed: 2026-10-13

# ADRB2

ENSG00000169252

Target class

GPCR

Chromosome

5

Approved drugs

50

Clinical candidates (approved and in development)

72

## Clinical evidence

**Approved drugs**

50

**Clinical candidates (approved and in development)**

72

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

ADRB2

**Gene name**

Adrenoceptor beta 2

**Gene symbol**

ADRB2

**Previous gene symbols**

- ADRB2R

**Protein name**

Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor)

### Other names (4)

- ADRBR
- BAR
- B2AR
- ARB2

## Classification

**Gene biotype**

Protein coding

**Gene family**

Adrenoceptors

**Target class**

GPCR

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

39

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

31.85

**Tissue specificity (Gini)**

0.611

**Tissue specificity (tau)**

0.849

## Pathways and interactions

**KEGG gene identifiers**

- hsa:154

**Protein interaction confidence**

0.833556

**Protein interaction partners**

63

### Reactome pathways (5)

- R-HSA-390696
- R-HSA-418555
- R-HSA-5689880
- R-HSA-8856825
- R-HSA-8856828

## Genomic location

**End position**

148828623

**Start position**

148826611

**Chromosome**

5

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000169252

**HGNC ID**

HGNC:286

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:286)

**NCBI Gene ID**

154

**UniProt ID**

P07550

## Cellular location

- Cell membrane
- Multi-pass membrane protein . Golgi apparatus . Note=Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325). Activated receptors are also detected within the Golgi apparatus (PubMed:27481942). .
- Plasma membrane

### Publication evidence (8)

- PubMed 19584355  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19584355/)
- PubMed 20559325  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20559325/)
- PubMed 23166351  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23166351/)
- PubMed 25220262  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25220262/)
- PubMed 2831218  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/2831218/)
- PubMed 7915137  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7915137/)
- PubMed 24056936  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24056936/)
- PubMed 27481942  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27481942/)

## Tissue expression

**Tissue specificity (tau)**

0.849371

**Expression inequality (Gini)**

0.611445

### Highest expression

Expression in transcripts per million

**Skin - Not Sun Exposed (Suprapubic)**

31.85

**Skin - Sun Exposed (Lower leg)**

27.52

**Breast - Mammary Tissue**

27.44

**Adipose - Subcutaneous**

25.62

**Adipose - Visceral (Omentum)**

19.9

### All tissues (54)

Expression in transcripts per million

- Skin - Not Sun Exposed (Suprapubic)31.85
- Skin - Sun Exposed (Lower leg)27.52
- Breast - Mammary Tissue27.44
- Adipose - Subcutaneous25.62
- Adipose - Visceral (Omentum)19.9
- Lung16.73
- Vagina12.96
- Esophagus - Mucosa9.09
- Spleen8.48
- Nerve - Tibial6.38
- Cervix - Ectocervix6.26
- Prostate6
- Esophagus - Muscularis4.96
- Esophagus - Gastroesophageal Junction4.85
- Minor Salivary Gland4.83
- Artery - Coronary4.13
- Whole Blood4.06
- Uterus3.91
- Fallopian Tube3.75
- Muscle - Skeletal3.72
- Bladder3.64
- Small Intestine - Terminal Ileum3.58
- Heart - Atrial Appendage3.47
- Liver3.41
- Cervix - Endocervix3.02

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (14)

- GO:0006898  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006898)
- GO:0007166  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007166)
- GO:0007188  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007188)
- GO:0008333  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008333)
- GO:0043410  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410)
- GO:0045744  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045744)
- GO:0071875  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071875)
- GO:0071880  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071880)
- GO:0098990  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098990)
- GO:1900451  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1900451)
- GO:1901098  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1901098)
- GO:1904504  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904504)
- GO:1904646  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904646)
- GO:1990911  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990911)

### Cellular components (7)

- GO:0005764  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005764)
- GO:0005768  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005768)
- GO:0005794  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0010008  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010008)
- GO:0030669  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030669)
- GO:0043235  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235)

### Molecular functions (8)

- GO:0001540  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001540)
- GO:0004941  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004941)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0015459  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015459)
- GO:0042802  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802)
- GO:0042803  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803)
- GO:0044877  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044877)
- GO:0051380  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051380)

## On-target safety

- bronchospasm  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: bronchospasm  
### Biological samples (2)

  - cardiovascular
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased blood glucose  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased blood glucose  
### Biological samples (2)

  - cardiovascular
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased blood potassium  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased blood potassium  
### Biological samples (2)

  - cardiovascular
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased blood pressure  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased blood pressure  
### Biological samples (2)

  - cardiovascular
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- Promotion, mesovarian leiomyomas  
### Effects

  - Activation/Increase/Upregulation  
### Studies

  - cell-based  
Evidence source  
Source: [aopwiki.org](https://aopwiki.org/aops/164)
- cardiovascular performance  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - clinical: cardiovascular performance  
### Biological samples

  - cardiovascular system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- bradycardia  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - clinical: bradycardia  
### Biological samples

  - cardiovascular system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- cardiac contractility  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - clinical: cardiac contractility  
### Biological samples

  - cardiovascular system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- vasodilatation of the vascular beds of skeletal muscle  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - clinical: vasodilatation of the vascular beds of skeletal muscle  
### Biological samples

  - cardiovascular system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- hypotonia  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - clinical: hypotonia  
### Biological samples

  - cardiovascular system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- smooth muscle relaxation  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - clinical: smooth muscle relaxation  
### Biological samples

  - cardiovascular system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- heart failure  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: heart failure  
### Biological samples (2)

  - cardiovascular
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased cardiac contractility  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased cardiac contractility  
### Biological samples (2)

  - cardiovascular
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased heart rate  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased heart rate  
### Biological samples (2)

  - cardiovascular
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased QTc interval  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased QTc interval  
### Biological samples (2)

  - cardiovascular
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)

## Off-target safety

- bronchodilation  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: bronchodilation  
### Biological samples (2)

  - cardiovascular system
  - pulmonary  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- increased heart rate  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: increased heart rate  
### Biological samples (2)

  - cardiovascular system
  - pulmonary  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- receptor binding  
### Studies

  - biochemical: NVS\_GPCR\_hAdrb2, is one of one assay component(s) measured or calculated from the NVS\_GPCR\_hAdrb2 assay. It is designed to make measurements of radioligand binding, a form of binding reporter, as detected with scintillation counting signals by Filter-based radiodetection technology.  
### Biological samples

  - cell-free  
Evidence source  
Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data)
- peripheral vasodilation  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: peripheral vasodilation  
### Biological samples (2)

  - cardiovascular system
  - pulmonary  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- increased glycogenolysis and glucagon release  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: increased glycogenolysis and glucagon release  
### Biological samples (2)

  - cardiovascular system
  - pulmonary  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- skeletal muscle tremor  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: skeletal muscle tremor  
### Biological samples (2)

  - cardiovascular system
  - pulmonary  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- decreased blood pressure  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: decreased blood pressure  
### Biological samples (2)

  - cardiovascular system
  - pulmonary  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)

## Related records

### Trials (3,125)

- : Vascular Function in Health and Disease
- ''Efficacy of Propranolol in the Treatment of Infantile Hemangioma"
- "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat
- "The Effect Of Subcutaneous Epinephrine Dosage On Blood Loss In Surgical Incision"
- "The Efficacy of Exparel Versus a Multidrug Cocktail in Soft Tissue Tumors"
- "The Evaluation of Stimulant Withdrawal"
- (CARE Network Trial - Treating Children to Prevent Exacerbations of Asthma (TREXA)
- 10 Vs.15 mcg Norepinephrine Bolus in Severe Maternal Hypotension During Cesarean Delivery
- 12 / 48 Week Pivotal PFT vs PBO in COPD I
- 12 / 48 wk Pivotal PFT vs PBO in COPD II
- 12-week Efficacy of Indacaterol
- 12-week Open-label Evaluation of Efficacy and Safety of Indacaterol
- ¹³C-Methacetin Breath Test (MBT) Methodology Study
- 24 Hour Ambulatory Cardiac Oxygen Consumption
- 24-hour Control of Intraocular Pressure (IOP) in Ocular Hypertension
- 24-hour Efficacy and Ocular Surface With Talfuprost and Triple Combined Therapy
- 24-hour Efficacy and Tolerability of the Tafluprost-timolol Fixed Association Without Preservatives in Glaucomatous or Ocular Hypertensive Patients Already Treated With Latanoprost Preserved With BAK. A Prospective, Open Study of 3 Months Duration.
- 24-Hour Intraocular Pressure (IOP) And Blood Pressure Control In Glaucoma And Ocular Hypertension Patients
- 24-hour Intraocular Pressure (IOP) Control With the Bimatoprost/Timolol Fixed Combination
- 24-Hour Intraocular Pressure (IOP) Control With Travoprost/Timolol Fixed Combination

### Drugs (108)

- [Abediterol](https://trialight.com/data/asset/abediterol-53a77fb7-0b78-4d57-99f8-2c8f24715a70.md) Beta-2 adrenergic receptor agonist
- Albuterol Beta-2 adrenergic receptor agonist
- [Albuterol sulfate](https://trialight.com/data/asset/albuterol-sulfate-2dd2d404-b0a0-4c65-9f6e-2fa1ab444b30.md) Beta-2 adrenergic receptor agonist
- Arformoterol Beta-2 adrenergic receptor agonist
- Arformoterol tartrate Beta-2 adrenergic receptor agonist
- AZD3199 Beta-2 adrenergic receptor agonist
- Bambuterol Beta-2 adrenergic receptor agonist
- Bamosiran Beta-2 adrenergic receptor mRNA RNAi inhibitor
- Batefenterol Beta-2 adrenergic receptor agonist
- Bedoradrine Beta-2 adrenergic receptor agonist
- Bedoradrine sulfate Beta-2 adrenergic receptor agonist
- Bitolterol Beta-2 adrenergic receptor agonist
- Bitolterol mesylate Beta-2 adrenergic receptor agonist
- Bucindolol Beta-2 adrenergic receptor antagonist
- Bucindolol hydrochloride Beta-2 adrenergic receptor antagonist
- Carmoterol Beta-2 adrenergic receptor agonist
- Carteolol Adrenergic receptor beta antagonist
- Carteolol hydrochloride Adrenergic receptor beta antagonist
- Carvedilol Adrenergic receptor beta antagonist
- Carvedilol phosphate Adrenergic receptor beta antagonist

---

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