> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/adrb1-6e315eb7-4a1a-5347-bacb-acfe97cbc2b5 > Record changed: 2026-10-13 # ADRB1 ENSG00000043591 Target class GPCR Chromosome 10 Approved drugs 44 Clinical candidates (approved and in development) 49 ## Clinical evidence **Approved drugs** 44 **Clinical candidates (approved and in development)** 49 ## Druggability **Chemical probe available** Yes ## Names **Target name** ADRB1 **Gene name** Adrenoceptor beta 1 **Gene symbol** ADRB1 **Previous gene symbols** - ADRB1R **Protein name** Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) ## Classification **Gene biotype** Protein coding **Gene family** Adrenoceptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 28 **Highest tissue expression** 24.29 **Tissue specificity (Gini)** 0.659 **Tissue specificity (tau)** 0.885 ## Pathways and interactions **KEGG gene identifiers** - hsa:153 **Protein interaction confidence** 0.866037 **Protein interaction partners** 27 ### Reactome pathways (2) - R-HSA-390696 - R-HSA-418555 ## Genomic location **End position** 114046904 **Start position** 114043866 **Chromosome** 10 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000043591 **HGNC ID** HGNC:285 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:285) **NCBI Gene ID** 153 **UniProt ID** P08588 ## Cellular location - Cell membrane - Multi-pass membrane protein . Note=Colocalizes with RAPGEF2 at the plasma membrane (By similarity). Localized at the plasma membrane (By similarity). Found in the Golgi upon GOPC overexpression (PubMed:15358775). Localized to early endosomes during endocytic trafficking (PubMed:21540189). . ### Publication evidence (3) - PubMed 33093660 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/33093660/) - PubMed 15358775 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15358775/) - PubMed 21540189 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21540189/) ## Tissue expression **Tissue specificity (tau)** 0.885037 **Expression inequality (Gini)** 0.659271 ### Highest expression Expression in transcripts per million **Lung** 24.29 **Heart - Atrial Appendage** 14.6 **Heart - Left Ventricle** 14.09 **Brain - Nucleus accumbens (basal ganglia)** 12.9 **Brain - Cortex** 12.03 ### All tissues (54) Expression in transcripts per million - Lung24.29 - Heart - Atrial Appendage14.6 - Heart - Left Ventricle14.09 - Brain - Nucleus accumbens (basal ganglia)12.9 - Brain - Cortex12.03 - Brain - Frontal Cortex (BA9)11.32 - Brain - Caudate (basal ganglia)6.94 - Brain - Anterior cingulate cortex (BA24)6.88 - Brain - Putamen (basal ganglia)6.07 - Prostate5.63 - Adipose - Visceral (Omentum)5.25 - Esophagus - Muscularis4.74 - Brain - Amygdala3.86 - Colon - Sigmoid3.59 - Esophagus - Gastroesophageal Junction3.41 - Small Intestine - Terminal Ileum2.97 - Brain - Hippocampus2.95 - Brain - Substantia nigra2.72 - Spleen2.45 - Artery - Coronary2.32 - Brain - Hypothalamus2.22 - Breast - Mammary Tissue2.18 - Adipose - Subcutaneous2.08 - Colon - Transverse1.97 - Brain - Cerebellum1.51 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (4) - GO:0001996 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001996) - GO:0007189 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007189) - GO:0045187 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045187) - GO:0071880 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071880) ### Cellular components (2) - GO:0005769 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005769) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (6) - GO:0004939 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004939) - GO:0004940 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004940) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0030165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030165) - GO:0031694 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031694) - GO:0046982 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046982) ## On-target safety - cardiac hypertrophy ### Effects - Activation/Increase/Upregulation: chronic ### Studies - preclinical: cardiac hypertrophy ### Biological samples - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased heart rate ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased heart rate ### Biological samples - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased heart rate ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: increased heart rate ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - increased heart rate ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased heart rate ### Biological samples - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - relaxation of blood vessels ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: relaxation of blood vessels ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - cardiovascular performance ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: cardiovascular performance ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - bradycardia ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: bradycardia ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - ventricular fibrillation ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: ventricular fibrillation ### Biological samples - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - bronchospasm ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: bronchospasm ### Biological samples - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - cardiac muscle stimulation ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: cardiac muscle stimulation ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - myocardial fibrosis ### Effects - Activation/Increase/Upregulation: chronic ### Studies - preclinical: myocardial fibrosis ### Biological samples - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - heart failure ### Effects - Activation/Increase/Upregulation: chronic ### Studies - preclinical: heart failure ### Biological samples - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased cardiac contractility ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased cardiac contractility ### Biological samples - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased force of contraction ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: increased force of contraction ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - decreased blood pressure ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased blood pressure ### Biological samples - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) ## Off-target safety - electrolyte disturbances ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: electrolyte disturbances ### Biological samples (2) - cardiovascular system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - receptor binding ### Studies - biochemical: NVS\_GPCR\_hAdrb1, is one of one assay component(s) measured or calculated from the NVS\_GPCR\_hAdrb1 assay. It is designed to make measurements of radioligand binding, a form of binding reporter, as detected with scintillation counting signals by Filter-based radiodetection technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - increased cardiac contractility ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: increased cardiac contractility ### Biological samples (2) - cardiovascular system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - decreased cardiac output ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: decreased cardiac output ### Biological samples (2) - cardiovascular system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - increased renin release ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: increased renin release ### Biological samples (2) - cardiovascular system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - increased heart rate ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: increased heart rate ### Biological samples (2) - cardiovascular system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - decreased heart rate ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: decreased heart rate ### Biological samples (2) - cardiovascular system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - lipolysis ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: lipolysis ### Biological samples (2) - cardiovascular system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - relaxation of colon and oesophagus ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: relaxation of colon and oesophagus ### Biological samples (2) - cardiovascular system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - decreased blood pressure ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: decreased blood pressure ### Biological samples (2) - cardiovascular system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) ## Related records ### Trials (2,115) - : Vascular Function in Health and Disease - ''Efficacy of Propranolol in the Treatment of Infantile Hemangioma" - "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat - "The Effect Of Subcutaneous Epinephrine Dosage On Blood Loss In Surgical Incision" - "The Efficacy of Exparel Versus a Multidrug Cocktail in Soft Tissue Tumors" - "The Evaluation of Stimulant Withdrawal" - 10 Vs.15 mcg Norepinephrine Bolus in Severe Maternal Hypotension During Cesarean Delivery - ¹³C-Methacetin Breath Test (MBT) Methodology Study - 24 Hour Ambulatory Cardiac Oxygen Consumption - 24-hour Control of Intraocular Pressure (IOP) in Ocular Hypertension - 24-hour Efficacy and Ocular Surface With Talfuprost and Triple Combined Therapy - 24-hour Efficacy and Tolerability of the Tafluprost-timolol Fixed Association Without Preservatives in Glaucomatous or Ocular Hypertensive Patients Already Treated With Latanoprost Preserved With BAK. A Prospective, Open Study of 3 Months Duration. - 24-Hour Intraocular Pressure (IOP) And Blood Pressure Control In Glaucoma And Ocular Hypertension Patients - 24-hour Intraocular Pressure (IOP) Control With the Bimatoprost/Timolol Fixed Combination - 24-Hour Intraocular Pressure (IOP) Control With Travoprost/Timolol Fixed Combination - 24-Hour Intraocular Pressure Control With Bimatoprost/Timolol Versus Latanoprost as First Choice - 24-hour Intraocular Pressure Control With Travoprost/Timolol Fixed Combination Versus Travoprost - 24-Hour Intraocular Pressure With Brinzolamide/Timolol Versus Brimonidine/Timolol - 24-hour Study of Dorzolamide/Timolol and Latanoprost/Timolol Fixed Combinations - 24-hr Intraocular Pressure Control With Dorzolamide/Timolol vs the Brimonidine/Timolol Fixed Combination ### Drugs (74) - Acebutolol Beta-1 adrenergic receptor antagonist - Acebutolol hydrochloride Beta-1 adrenergic receptor antagonist - Atenolol Beta-1 adrenergic receptor antagonist - Betaxolol Beta-1 adrenergic receptor antagonist - Betaxolol hydrochloride Beta-1 adrenergic receptor antagonist - Bisoprolol Beta-1 adrenergic receptor antagonist - Bisoprolol fumarate Beta-1 adrenergic receptor antagonist - Bucindolol Beta-1 adrenergic receptor antagonist - Bucindolol hydrochloride Beta-1 adrenergic receptor antagonist - Carteolol Adrenergic receptor beta antagonist - Carteolol hydrochloride Adrenergic receptor beta antagonist - Carvedilol Adrenergic receptor beta antagonist - Carvedilol phosphate Adrenergic receptor beta antagonist - Celiprolol Beta-1 adrenergic receptor antagonist - Dilevalol Adrenergic receptor beta antagonist - Dilevalol hydrochloride Adrenergic receptor beta antagonist - Dipivefrin Adrenergic receptor agonist - Dipivefrin hydrochloride Adrenergic receptor agonist - Dobutamine Beta-1 adrenergic receptor agonist - Dobutamine hydrochloride Beta-1 adrenergic receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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