> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/adra2c-2db30d55-ac07-5bc1-abeb-0a9ed88bca80
> Record changed: 2026-11-04

# ADRA2C

ENSG00000184160

Target class

GPCR

Chromosome

4

Approved drugs

34

Clinical candidates (approved and in development)

42

## Clinical evidence

**Approved drugs**

34

**Clinical candidates (approved and in development)**

42

## Druggability

**Chemical probe available**

Yes

## Names

**Other names**

- ADRARL2

**Target name**

ADRA2C

**Gene name**

Adrenoceptor alpha 2C

**Gene symbol**

ADRA2C

**Protein name**

Alpha-2C adrenergic receptor (Alpha-2 adrenergic receptor subtype C4) (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2CAR)

### Previous gene symbols (2)

- ADRA2L2
- ADRA2RL2

## Classification

**Gene biotype**

Protein coding

**Gene family**

Adrenoceptors

**Target class**

GPCR

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

50

**Highest tissue expression**

212.02

**Tissue specificity (Gini)**

0.715

**Tissue specificity (tau)**

0.912

## Pathways and interactions

**KEGG gene identifiers**

- hsa:152

**Protein interaction confidence**

0.826444

**Protein interaction partners**

9

### Reactome pathways (6)

- R-HSA-390696
- R-HSA-392023
- R-HSA-400042
- R-HSA-418594
- R-HSA-418597
- R-HSA-5683826

## Genomic location

**End position**

3768526

**Start position**

3766348

**Chromosome**

4

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000184160

**HGNC ID**

HGNC:283

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:283)

**NCBI Gene ID**

152

**UniProt ID**

P18825

## Cellular location

- Cell membrane
- Multi-pass membrane protein .

## Tissue expression

**Tissue specificity (tau)**

0.91169

**Expression inequality (Gini)**

0.715049

### Highest expression

Expression in transcripts per million

**Cervix - Endocervix**

212.02

**Artery - Aorta**

191.51

**Artery - Tibial**

128.65

**Cervix - Ectocervix**

90.99

**Uterus**

71.13

### All tissues (54)

Expression in transcripts per million

- Cervix - Endocervix212.02
- Artery - Aorta191.51
- Artery - Tibial128.65
- Cervix - Ectocervix90.99
- Uterus71.13
- Artery - Coronary54.99
- Fallopian Tube50.73
- Kidney - Medulla40.31
- Prostate33.56
- Spleen32.3
- Brain - Caudate (basal ganglia)27.81
- Adipose - Subcutaneous24.68
- Brain - Putamen (basal ganglia)23.73
- Brain - Nucleus accumbens (basal ganglia)17.72
- Vagina16.28
- Kidney - Cortex14.84
- Adipose - Visceral (Omentum)12.82
- Breast - Mammary Tissue12.7
- Nerve - Tibial10.07
- Skin - Sun Exposed (Lower leg)10.06
- Testis8.44
- Pituitary7.58
- Lung7.37
- Skin - Not Sun Exposed (Suprapubic)6.86
- Brain - Anterior cingulate cortex (BA24)6.64

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (10)

- GO:0007173  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007173)
- GO:0007186  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186)
- GO:0007267  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007267)
- GO:0010700  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010700)
- GO:0043410  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410)
- GO:0045666  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045666)
- GO:0046676  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046676)
- GO:0051897  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897)
- GO:0071875  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071875)
- GO:0071881  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071881)

### Cellular components (3)

- GO:0005737  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)
- GO:0005768  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005768)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)

### Molecular functions (6)

- GO:0004938  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004938)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0031694  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031694)
- GO:0042803  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803)
- GO:0046982  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046982)
- GO:0051379  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051379)

## On-target safety

- hypertension  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - clinical: hypertension  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- stress response  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - clinical: stress response  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- venous contraction (contraction of human saphenous vein)  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - clinical: venous contraction (contraction of human saphenous vein)  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- cardiac ischemia  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - clinical: cardiac ischemia  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- startle reflex  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - clinical: startle reflex  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- locomotion  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - clinical: locomotion  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)

## Off-target safety

- receptor binding  
### Studies

  - biochemical: NVS\_GPCR\_hAdra2C, is one of one assay component(s) measured or calculated from the NVS\_GPCR\_hAdra2C assay. It is designed to make measurements of radioligand binding, a form of binding reporter, as detected with scintillation counting signals by Filter-based radiodetection technology.  
### Biological samples

  - cell-free  
Evidence source  
Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data)

## Related records

### Trials (3,661)

- : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic
- : Vascular Function in Health and Disease
- "Brexpiprazole (Rexulti™) Safety and Efficacy Among Filipino Patients (RAISE) - A Post Marketing Surveillance Program"
- "Efficacy and Safety of Brimonidine Tartrate Preservative-Free Formulation in Adults With Ocular Redness"
- "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat
- "The Effect Of Subcutaneous Epinephrine Dosage On Blood Loss In Surgical Incision"
- \[11C\]Yohimbine PET Study of alpha2-AR
- 10 Vs.15 mcg Norepinephrine Bolus in Severe Maternal Hypotension During Cesarean Delivery
- 15 mg Mirtazapine Orally Disintegrating Tablets, Fasting
- 15 mg Mirtazapine Orally Disintegrating Tablets, Non-Fasting
- 18F-DOPA PET to Elucidate the Antidepressant Mechanism of Lurasidone in Bipolar Disorder
- 24-hour IOP-lowering Effect of Brimonidine 0.1%
- 24-hr Intraocular Pressure Control With SIMBRINZA ®
- 4"S" - Seasonal Symptoms Suppression Study
- 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis
- 5 Versus 10 mcg Norepinephrine Bolus in Treatment of Postinduction and Early Intraoperative Hypotension in Emergency Abdominal Surgery
- 5HT2CR Balance in Brain Connectivity in Cocaine Dependence
- 7% Hypertonic Saline for Acute Bronchiolitis
- 95% Effective Dose(ED95) of Remimazolam During Dexmedetomidine Pretreatment
- A 12-week Extension Trial to Evaluate the Safety and Tolerability of Brexpiprazole in the Treatment of Subjects With Agitation Associated With Dementia of the Alzheimer's Type

### Drugs (90)

- Alseroxylon Adrenergic receptor alpha antagonist
- Apomorphine
- Apraclonidine Adrenergic receptor alpha-2 agonist
- Apraclonidine hydrochloride Adrenergic receptor alpha-2 agonist
- Atipamezole
- Aviptadil Adrenergic receptor alpha antagonist
- Brexpiprazole
- Brimonidine Adrenergic receptor alpha-2 agonist
- Brimonidine tartrate Adrenergic receptor alpha-2 agonist
- Bromocriptine
- Cabergoline
- Celiprolol Adrenergic receptor alpha-2 antagonist
- Celiprolol hydrochloride Adrenergic receptor alpha-2 antagonist
- Chlorpromazine
- Clonidine Adrenergic receptor alpha-2 agonist
- Clonidine hydrochloride Adrenergic receptor alpha-2 agonist
- Detomidine
- Dexmedetomidine Adrenergic receptor alpha-2 agonist
- Dexmedetomidine hydrochloride Adrenergic receptor alpha-2 agonist
- Dipivefrin Adrenergic receptor agonist

---

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