ADRA2C
ENSG00000184160
Target class
GPCR
Chromosome
4
Approved drugs
34
Clinical candidates (approved and in development)
42
- Approved drugs
- 34
- Clinical candidates (approved and in development)
- 42
- Chemical probe available
- Yes
- Other names
- ADRARL2
- Target name
- ADRA2C
- Gene name
- Adrenoceptor alpha 2C
- Gene symbol
- ADRA2C
- Protein name
- Alpha-2C adrenergic receptor (Alpha-2 adrenergic receptor subtype C4) (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2CAR)
- ADRA2L2
- ADRA2RL2
- Gene biotype
- Protein coding
- Gene family
- Adrenoceptors
- Target class
- GPCR
- Target type
- Human gene
- Tissues expressed in
- 50
- Highest tissue expression
- 212.02
- Tissue specificity (Gini)
- 0.715
- Tissue specificity (tau)
- 0.912
- KEGG gene identifiers
- hsa:152
- Protein interaction confidence
- 0.826444
- Protein interaction partners
- 9
- R-HSA-390696
- R-HSA-392023
- R-HSA-400042
- R-HSA-418594
- R-HSA-418597
- R-HSA-5683826
- End position
- 3768526
- Start position
- 3766348
- Chromosome
- 4
- Strand
- Forward
- Cell membrane
- Multi-pass membrane protein .
- Tissue specificity (tau)
- 0.91169
- Expression inequality (Gini)
- 0.715049
Expression in transcripts per million
- Cervix - Endocervix
- 212.02
- Artery - Aorta
- 191.51
- Artery - Tibial
- 128.65
- Cervix - Ectocervix
- 90.99
- Uterus
- 71.13
Expression in transcripts per million
- Cervix - Endocervix212.02
- Artery - Aorta191.51
- Artery - Tibial128.65
- Cervix - Ectocervix90.99
- Uterus71.13
- Artery - Coronary54.99
- Fallopian Tube50.73
- Kidney - Medulla40.31
- Prostate33.56
- Spleen32.3
- Brain - Caudate (basal ganglia)27.81
- Adipose - Subcutaneous24.68
- Brain - Putamen (basal ganglia)23.73
- Brain - Nucleus accumbens (basal ganglia)17.72
- Vagina16.28
- Kidney - Cortex14.84
- Adipose - Visceral (Omentum)12.82
- Breast - Mammary Tissue12.7
- Nerve - Tibial10.07
- Skin - Sun Exposed (Lower leg)10.06
- Testis8.44
- Pituitary7.58
- Lung7.37
- Skin - Not Sun Exposed (Suprapubic)6.86
- Brain - Anterior cingulate cortex (BA24)6.64
And 29 more, listed on the interactive page.
- GO:0007173
- GO:0007186
- GO:0007267
- GO:0010700
- GO:0043410
- GO:0045666
- GO:0046676
- GO:0051897
- GO:0071875
- GO:0071881
- GO:0005737
- GO:0005768
- GO:0005886
- GO:0004938
- GO:0005515
- GO:0031694
- GO:0042803
- GO:0046982
- GO:0051379
hypertension
Effects
- Activation/Increase/Upregulation: general
Studies
- clinical: hypertension
- cardiovascular system
- central nervous system
Evidence sourcestress response
Effects
- Activation/Increase/Upregulation: general
Studies
- clinical: stress response
- cardiovascular system
- central nervous system
Evidence sourcevenous contraction (contraction of human saphenous vein)
Effects
- Activation/Increase/Upregulation: general
Studies
- clinical: venous contraction (contraction of human saphenous vein)
- cardiovascular system
- central nervous system
Evidence sourcecardiac ischemia
Effects
- Activation/Increase/Upregulation: general
Studies
- clinical: cardiac ischemia
- cardiovascular system
- central nervous system
Evidence sourcestartle reflex
Effects
- Activation/Increase/Upregulation: general
Studies
- clinical: startle reflex
- cardiovascular system
- central nervous system
Evidence sourcelocomotion
Effects
- Activation/Increase/Upregulation: general
Studies
- clinical: locomotion
- cardiovascular system
- central nervous system
Evidence source
receptor binding
Studies
- biochemical: NVS_GPCR_hAdra2C, is one of one assay component(s) measured or calculated from the NVS_GPCR_hAdra2C assay. It is designed to make measurements of radioligand binding, a form of binding reporter, as detected with scintillation counting signals by Filter-based radiodetection technology.
Biological samples
- cell-free
Evidence source
Related records
Trials (3,661)
- : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic
- : Vascular Function in Health and Disease
- "Brexpiprazole (Rexulti™) Safety and Efficacy Among Filipino Patients (RAISE) - A Post Marketing Surveillance Program"
- "Efficacy and Safety of Brimonidine Tartrate Preservative-Free Formulation in Adults With Ocular Redness"
- "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat
- "The Effect Of Subcutaneous Epinephrine Dosage On Blood Loss In Surgical Incision"
- [11C]Yohimbine PET Study of alpha2-AR
- 10 Vs.15 mcg Norepinephrine Bolus in Severe Maternal Hypotension During Cesarean Delivery
- 15 mg Mirtazapine Orally Disintegrating Tablets, Fasting
- 15 mg Mirtazapine Orally Disintegrating Tablets, Non-Fasting
- 18F-DOPA PET to Elucidate the Antidepressant Mechanism of Lurasidone in Bipolar Disorder
- 24-hour IOP-lowering Effect of Brimonidine 0.1%
- 24-hr Intraocular Pressure Control With SIMBRINZA ®
- 4"S" - Seasonal Symptoms Suppression Study
- 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis
- 5 Versus 10 mcg Norepinephrine Bolus in Treatment of Postinduction and Early Intraoperative Hypotension in Emergency Abdominal Surgery
- 5HT2CR Balance in Brain Connectivity in Cocaine Dependence
- 7% Hypertonic Saline for Acute Bronchiolitis
- 95% Effective Dose(ED95) of Remimazolam During Dexmedetomidine Pretreatment
- A 12-week Extension Trial to Evaluate the Safety and Tolerability of Brexpiprazole in the Treatment of Subjects With Agitation Associated With Dementia of the Alzheimer's Type
Drugs (90)
- Alseroxylon Adrenergic receptor alpha antagonist
- Apomorphine
- Apraclonidine Adrenergic receptor alpha-2 agonist
- Apraclonidine hydrochloride Adrenergic receptor alpha-2 agonist
- Atipamezole
- Aviptadil Adrenergic receptor alpha antagonist
- Brexpiprazole
- Brimonidine Adrenergic receptor alpha-2 agonist
- Brimonidine tartrate Adrenergic receptor alpha-2 agonist
- Bromocriptine
- Cabergoline
- Celiprolol Adrenergic receptor alpha-2 antagonist
- Celiprolol hydrochloride Adrenergic receptor alpha-2 antagonist
- Chlorpromazine
- Clonidine Adrenergic receptor alpha-2 agonist
- Clonidine hydrochloride Adrenergic receptor alpha-2 agonist
- Detomidine
- Dexmedetomidine Adrenergic receptor alpha-2 agonist
- Dexmedetomidine hydrochloride Adrenergic receptor alpha-2 agonist
- Dipivefrin Adrenergic receptor agonist