> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/adra2b-f20de6d0-ab0d-595e-a82d-373a4c9c508e
> Record changed: 2026-11-04

# ADRA2B

ENSG00000274286

Target class

GPCR

Chromosome

2

Approved drugs

34

Clinical candidates (approved and in development)

41

## Clinical evidence

**Approved drugs**

34

**ClinGen gene-disease validity**

Refuted

**Clinical candidates (approved and in development)**

41

## Druggability

**Chemical probe available**

Yes

## Names

**Other names**

- ADRARL1

**Target name**

ADRA2B

**Gene name**

Adrenoceptor alpha 2B

**Gene symbol**

ADRA2B

**Protein name**

Alpha-2B adrenergic receptor (Alpha-2 adrenergic receptor subtype C2) (Alpha-2B adrenoreceptor) (Alpha-2B adrenoceptor) (Alpha-2BAR)

### Previous gene symbols (2)

- ADRA2L1
- ADRA2RL1

## Classification

**Gene biotype**

Protein coding

**Gene family**

Adrenoceptors

**Target class**

GPCR

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

39

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

13.12

**Tissue specificity (Gini)**

0.451

**Tissue specificity (tau)**

0.766

## Pathways and interactions

**KEGG gene identifiers**

- hsa:151

**Protein interaction confidence**

0.8796

**Protein interaction partners**

5

### Reactome pathways (4)

- R-HSA-390696
- R-HSA-392023
- R-HSA-418594
- R-HSA-418597

## Genomic location

**End position**

96116571

**Start position**

96112876

**Chromosome**

2

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000274286

**HGNC ID**

HGNC:282

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:282)

**NCBI Gene ID**

151

**UniProt ID**

P18089

## Cellular location

- Cell membrane
- Multi-pass membrane protein . Note=Interaction with RAB26, GGA1, GGA2 and GGA3 mediates transport from the Golgi to the cell membrane. .
- Cytosol
- Vesicles

### Publication evidence (5)

- PubMed 23105096  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23105096/)
- PubMed 26811329  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26811329/)
- PubMed 27901063  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27901063/)
- PubMed 29069590  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/29069590/)
- PubMed 32152538  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/32152538/)

## Tissue expression

**Tissue specificity (tau)**

0.765733

**Expression inequality (Gini)**

0.451449

### Highest expression

Expression in transcripts per million

**Spleen**

13.12

**Adipose - Subcutaneous**

10.07

**Nerve - Tibial**

10.05

**Esophagus - Muscularis**

7.61

**Adipose - Visceral (Omentum)**

7.31

### All tissues (54)

Expression in transcripts per million

- Spleen13.12
- Adipose - Subcutaneous10.07
- Nerve - Tibial10.05
- Esophagus - Muscularis7.61
- Adipose - Visceral (Omentum)7.31
- Esophagus - Gastroesophageal Junction6.6
- Uterus6.14
- Artery - Aorta5.79
- Kidney - Medulla5.71
- Heart - Left Ventricle5.3
- Breast - Mammary Tissue5.29
- Fallopian Tube5.09
- Artery - Tibial5.08
- Muscle - Skeletal5.04
- Liver4.64
- Bladder4.42
- Colon - Sigmoid3.95
- Small Intestine - Terminal Ileum3.88
- Kidney - Cortex3.54
- Artery - Coronary3.44
- Cervix - Ectocervix3.34
- Cervix - Endocervix3.34
- Testis3.12
- Skin - Sun Exposed (Lower leg)3.02
- Thyroid2.95

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (10)

- GO:0007173  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007173)
- GO:0007186  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186)
- GO:0007193  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007193)
- GO:0007267  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007267)
- GO:0010700  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010700)
- GO:0043410  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410)
- GO:0045666  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045666)
- GO:0051897  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897)
- GO:0071875  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071875)
- GO:0071881  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071881)

### Cellular components (2)

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0009986  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986)

### Molecular functions (3)

- GO:0004938  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004938)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0051379  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051379)

## On-target safety

- decreased blood pressure  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased blood pressure  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased heart failure  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased heart failure  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- skeletal muscle tremor  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: skeletal muscle tremor  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased blood pressure  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased blood pressure  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased survival  
### Effects

  - Inhibition/Decrease/Downregulation: developmental toxicity  
### Studies

  - preclinical: decreased survival  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased heart rate  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased heart rate  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- cardiac ischemia  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: cardiac ischemia  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased pain  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased pain  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- sedation  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: sedation  
### Biological samples (2)

  - nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)

## Related records

### Trials (3,501)

- : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic
- : Vascular Function in Health and Disease
- "Efficacy and Safety of Brimonidine Tartrate Preservative-Free Formulation in Adults With Ocular Redness"
- "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat
- "The Effect Of Subcutaneous Epinephrine Dosage On Blood Loss In Surgical Incision"
- \[11C\]Yohimbine PET Study of alpha2-AR
- 10 Vs.15 mcg Norepinephrine Bolus in Severe Maternal Hypotension During Cesarean Delivery
- 15 mg Mirtazapine Orally Disintegrating Tablets, Fasting
- 15 mg Mirtazapine Orally Disintegrating Tablets, Non-Fasting
- 24-hour IOP-lowering Effect of Brimonidine 0.1%
- 24-hr Intraocular Pressure Control With SIMBRINZA ®
- 4"S" - Seasonal Symptoms Suppression Study
- 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis
- 5 Versus 10 mcg Norepinephrine Bolus in Treatment of Postinduction and Early Intraoperative Hypotension in Emergency Abdominal Surgery
- 5HT2CR Balance in Brain Connectivity in Cocaine Dependence
- 7% Hypertonic Saline for Acute Bronchiolitis
- 95% Effective Dose(ED95) of Remimazolam During Dexmedetomidine Pretreatment
- A 6-Month Efficacy and Safety Study of Org 50081 in Adult Patients With Chronic Primary Insomnia (21106/P05701/MK-8265-002)
- A Cardiac Safety Study of an Investigational Drug to See How if Affects the Heart in People With Parkinson's Disease Complicated by Motor Fluctuations "OFF" Episodes
- A Clinical Endpoint Bioequivalence Study of "Oxymetazoline Hydrochloride Cream"

### Drugs (86)

- Alseroxylon Adrenergic receptor alpha antagonist
- Apomorphine
- Apraclonidine Adrenergic receptor alpha-2 agonist
- Apraclonidine hydrochloride Adrenergic receptor alpha-2 agonist
- Atipamezole
- Aviptadil Adrenergic receptor alpha antagonist
- Brimonidine Adrenergic receptor alpha-2 agonist
- Brimonidine tartrate Adrenergic receptor alpha-2 agonist
- Bromocriptine
- Cabergoline
- Celiprolol Adrenergic receptor alpha-2 antagonist
- Celiprolol hydrochloride Adrenergic receptor alpha-2 antagonist
- Chlorpromazine
- Clonidine Adrenergic receptor alpha-2 agonist
- Clonidine hydrochloride Adrenergic receptor alpha-2 agonist
- Detomidine
- Dexmedetomidine Adrenergic receptor alpha-2 agonist
- Dexmedetomidine hydrochloride Adrenergic receptor alpha-2 agonist
- Dipivefrin Adrenergic receptor agonist
- Dipivefrin hydrochloride Adrenergic receptor agonist

---

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