ADRA2B
ENSG00000274286
Target class
GPCR
Chromosome
2
Approved drugs
34
Clinical candidates (approved and in development)
41
- Approved drugs
- 34
- ClinGen gene-disease validity
- Refuted
- Clinical candidates (approved and in development)
- 41
- Chemical probe available
- Yes
- Other names
- ADRARL1
- Target name
- ADRA2B
- Gene name
- Adrenoceptor alpha 2B
- Gene symbol
- ADRA2B
- Protein name
- Alpha-2B adrenergic receptor (Alpha-2 adrenergic receptor subtype C2) (Alpha-2B adrenoreceptor) (Alpha-2B adrenoceptor) (Alpha-2BAR)
- ADRA2L1
- ADRA2RL1
- Gene biotype
- Protein coding
- Gene family
- Adrenoceptors
- Target class
- GPCR
- Target type
- Human gene
- Tissues expressed in
- 39
- Protein localisation evidence grade
- Supported
- Highest tissue expression
- 13.12
- Tissue specificity (Gini)
- 0.451
- Tissue specificity (tau)
- 0.766
- KEGG gene identifiers
- hsa:151
- Protein interaction confidence
- 0.8796
- Protein interaction partners
- 5
- R-HSA-390696
- R-HSA-392023
- R-HSA-418594
- R-HSA-418597
- End position
- 96116571
- Start position
- 96112876
- Chromosome
- 2
- Strand
- Reverse
- Cell membrane
- Multi-pass membrane protein . Note=Interaction with RAB26, GGA1, GGA2 and GGA3 mediates transport from the Golgi to the cell membrane. .
- Cytosol
- Vesicles
- PubMed 23105096
- PubMed 26811329
- PubMed 27901063
- PubMed 29069590
- PubMed 32152538
- Tissue specificity (tau)
- 0.765733
- Expression inequality (Gini)
- 0.451449
Expression in transcripts per million
- Spleen
- 13.12
- Adipose - Subcutaneous
- 10.07
- Nerve - Tibial
- 10.05
- Esophagus - Muscularis
- 7.61
- Adipose - Visceral (Omentum)
- 7.31
Expression in transcripts per million
- Spleen13.12
- Adipose - Subcutaneous10.07
- Nerve - Tibial10.05
- Esophagus - Muscularis7.61
- Adipose - Visceral (Omentum)7.31
- Esophagus - Gastroesophageal Junction6.6
- Uterus6.14
- Artery - Aorta5.79
- Kidney - Medulla5.71
- Heart - Left Ventricle5.3
- Breast - Mammary Tissue5.29
- Fallopian Tube5.09
- Artery - Tibial5.08
- Muscle - Skeletal5.04
- Liver4.64
- Bladder4.42
- Colon - Sigmoid3.95
- Small Intestine - Terminal Ileum3.88
- Kidney - Cortex3.54
- Artery - Coronary3.44
- Cervix - Ectocervix3.34
- Cervix - Endocervix3.34
- Testis3.12
- Skin - Sun Exposed (Lower leg)3.02
- Thyroid2.95
And 29 more, listed on the interactive page.
- GO:0007173
- GO:0007186
- GO:0007193
- GO:0007267
- GO:0010700
- GO:0043410
- GO:0045666
- GO:0051897
- GO:0071875
- GO:0071881
- GO:0005886
- GO:0009986
- GO:0004938
- GO:0005515
- GO:0051379
decreased blood pressure
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: decreased blood pressure
- nervous system
- cardiovascular
PubMed 28216264increased heart failure
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: increased heart failure
- nervous system
- cardiovascular
PubMed 28216264skeletal muscle tremor
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: skeletal muscle tremor
- nervous system
- cardiovascular
PubMed 28216264increased blood pressure
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: increased blood pressure
- nervous system
- cardiovascular
PubMed 28216264decreased survival
Effects
- Inhibition/Decrease/Downregulation: developmental toxicity
Studies
- preclinical: decreased survival
- nervous system
- cardiovascular
PubMed 28216264increased heart rate
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: increased heart rate
- nervous system
- cardiovascular
PubMed 28216264cardiac ischemia
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: cardiac ischemia
- nervous system
- cardiovascular
PubMed 28216264decreased pain
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: decreased pain
- nervous system
- cardiovascular
PubMed 28216264sedation
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: sedation
- nervous system
- cardiovascular
PubMed 28216264
Related records
Trials (3,501)
- : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic
- : Vascular Function in Health and Disease
- "Efficacy and Safety of Brimonidine Tartrate Preservative-Free Formulation in Adults With Ocular Redness"
- "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat
- "The Effect Of Subcutaneous Epinephrine Dosage On Blood Loss In Surgical Incision"
- [11C]Yohimbine PET Study of alpha2-AR
- 10 Vs.15 mcg Norepinephrine Bolus in Severe Maternal Hypotension During Cesarean Delivery
- 15 mg Mirtazapine Orally Disintegrating Tablets, Fasting
- 15 mg Mirtazapine Orally Disintegrating Tablets, Non-Fasting
- 24-hour IOP-lowering Effect of Brimonidine 0.1%
- 24-hr Intraocular Pressure Control With SIMBRINZA ®
- 4"S" - Seasonal Symptoms Suppression Study
- 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis
- 5 Versus 10 mcg Norepinephrine Bolus in Treatment of Postinduction and Early Intraoperative Hypotension in Emergency Abdominal Surgery
- 5HT2CR Balance in Brain Connectivity in Cocaine Dependence
- 7% Hypertonic Saline for Acute Bronchiolitis
- 95% Effective Dose(ED95) of Remimazolam During Dexmedetomidine Pretreatment
- A 6-Month Efficacy and Safety Study of Org 50081 in Adult Patients With Chronic Primary Insomnia (21106/P05701/MK-8265-002)
- A Cardiac Safety Study of an Investigational Drug to See How if Affects the Heart in People With Parkinson's Disease Complicated by Motor Fluctuations "OFF" Episodes
- A Clinical Endpoint Bioequivalence Study of "Oxymetazoline Hydrochloride Cream"
Drugs (86)
- Alseroxylon Adrenergic receptor alpha antagonist
- Apomorphine
- Apraclonidine Adrenergic receptor alpha-2 agonist
- Apraclonidine hydrochloride Adrenergic receptor alpha-2 agonist
- Atipamezole
- Aviptadil Adrenergic receptor alpha antagonist
- Brimonidine Adrenergic receptor alpha-2 agonist
- Brimonidine tartrate Adrenergic receptor alpha-2 agonist
- Bromocriptine
- Cabergoline
- Celiprolol Adrenergic receptor alpha-2 antagonist
- Celiprolol hydrochloride Adrenergic receptor alpha-2 antagonist
- Chlorpromazine
- Clonidine Adrenergic receptor alpha-2 agonist
- Clonidine hydrochloride Adrenergic receptor alpha-2 agonist
- Detomidine
- Dexmedetomidine Adrenergic receptor alpha-2 agonist
- Dexmedetomidine hydrochloride Adrenergic receptor alpha-2 agonist
- Dipivefrin Adrenergic receptor agonist
- Dipivefrin hydrochloride Adrenergic receptor agonist