> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/adra2a-3d9afd89-4da8-5e2a-ad8a-ec3201b943a7
> Record changed: 2026-11-04

# ADRA2A

ENSG00000150594

Target class

GPCR

Chromosome

10

Approved drugs

34

Clinical candidates (approved and in development)

41

## Clinical evidence

**Approved drugs**

34

**Clinical candidates (approved and in development)**

41

## Druggability

**Chemical probe available**

Yes

## Names

**Other names**

- ADRAR

**Target name**

ADRA2A

**Gene name**

Adrenoceptor alpha 2A

**Gene symbol**

ADRA2A

**Protein name**

Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR)

### Previous gene symbols (2)

- ADRA2
- ADRA2R

## Classification

**Gene biotype**

Protein coding

**Gene family**

Adrenoceptors

**Target class**

GPCR

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

45

**Highest tissue expression**

98.88

**Tissue specificity (Gini)**

0.657

**Tissue specificity (tau)**

0.873

## Pathways and interactions

**KEGG gene identifiers**

- hsa:150

**Protein interaction confidence**

0.822444

**Protein interaction partners**

18

### Reactome pathways (6)

- R-HSA-390696
- R-HSA-392023
- R-HSA-400042
- R-HSA-418594
- R-HSA-418597
- R-HSA-5683826

## Genomic location

**End position**

111080907

**Start position**

111077029

**Chromosome**

10

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000150594

**HGNC ID**

HGNC:281

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:281)

**NCBI Gene ID**

150

**UniProt ID**

P08913

## Cellular location

- Cell membrane
- Multi-pass membrane protein .

### Publication evidence (2)

- PubMed 23105096  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23105096/)
- PubMed 35245122  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/35245122/)

## Tissue expression

**Tissue specificity (tau)**

0.873307

**Expression inequality (Gini)**

0.656585

### Highest expression

Expression in transcripts per million

**Cervix - Ectocervix**

98.88

**Adipose - Subcutaneous**

91.91

**Cervix - Endocervix**

84.33

**Breast - Mammary Tissue**

56.22

**Adipose - Visceral (Omentum)**

39.05

### All tissues (54)

Expression in transcripts per million

- Cervix - Ectocervix98.88
- Adipose - Subcutaneous91.91
- Cervix - Endocervix84.33
- Breast - Mammary Tissue56.22
- Adipose - Visceral (Omentum)39.05
- Vagina37.74
- Ovary37.68
- Bladder25.71
- Nerve - Tibial23.32
- Pancreas18.56
- Thyroid18.37
- Skin - Sun Exposed (Lower leg)18.32
- Spleen13.58
- Uterus13.55
- Testis12.74
- Brain - Cerebellum12.22
- Prostate11.89
- Artery - Tibial11.74
- Skin - Not Sun Exposed (Suprapubic)10.58
- Brain - Cerebellar Hemisphere10.46
- Fallopian Tube10.16
- Minor Salivary Gland9.46
- Colon - Transverse9.08
- Artery - Coronary7.68
- Lung6.79

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (25)

- GO:0001819  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001819)
- GO:0007173  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007173)
- GO:0007186  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186)
- GO:0007265  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007265)
- GO:0007266  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007266)
- GO:0008284  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284)
- GO:0010700  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010700)
- GO:0030036  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030036)
- GO:0030335  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030335)
- GO:0032870  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032870)
- GO:0042593  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042593)
- GO:0043410  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410)
- GO:0045742  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045742)
- GO:0045955  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045955)
- GO:0046676  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046676)
- GO:0050892  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050892)
- GO:0050995  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050995)
- GO:0051044  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051044)
- GO:0051897  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897)
- GO:0061179  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061179)
- GO:0071875  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071875)
- GO:0071880  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071880)
- GO:0071881  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071881)
- GO:0071882  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071882)
- GO:0090303  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090303)

### Cellular components (4)

- GO:0005737  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0016323  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016323)
- GO:0043235  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235)

### Molecular functions (9)

- GO:0004938  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004938)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0019901  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019901)
- GO:0031696  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031696)
- GO:0031996  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031996)
- GO:0032795  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032795)
- GO:0042803  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803)
- GO:0051379  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051379)
- GO:0051380  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051380)

## On-target safety

- decreased body temperature  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased body temperature  
### Biological samples (4)

  - pancreas
  - nervous system
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- memory impairment  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - clinical: memory impairment  
### Biological samples (2)

  - cardiovascular system
  - nervous system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- decreased blood pressure  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased blood pressure  
### Biological samples (4)

  - pancreas
  - nervous system
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- Decreased, Decreased fecundity  
### Effects

  - Inhibition/Decrease/Downregulation  
### Studies

  - cell-based  
Evidence source  
Source: [aopwiki.org](https://aopwiki.org/aops/126)
- increased convulsions  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased convulsions  
### Biological samples (4)

  - pancreas
  - nervous system
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- hyperglycemia  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - clinical: hyperglycemia  
### Biological samples (2)

  - cardiovascular system
  - nervous system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- anesthetic-sparing effect  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - clinical: anesthetic-sparing effect  
### Biological samples (2)

  - cardiovascular system
  - nervous system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- sedation  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: sedation  
### Biological samples (4)

  - pancreas
  - nervous system
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- weight gain  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - clinical: weight gain  
### Biological samples (2)

  - cardiovascular system
  - nervous system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- decreased gastric emptying  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased gastric emptying  
### Biological samples (4)

  - pancreas
  - nervous system
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased pain  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased pain  
### Biological samples (4)

  - pancreas
  - nervous system
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- gastrointestinal prokinetic effects  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - clinical: gastrointestinal prokinetic effects  
### Biological samples (2)

  - cardiovascular system
  - nervous system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- decreased memory  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased memory  
### Biological samples (4)

  - pancreas
  - nervous system
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased blood insulin  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased blood insulin  
### Biological samples (4)

  - pancreas
  - nervous system
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- central hypotension (reduction of blood pressure and heart rate)  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - clinical: central hypotension (reduction of blood pressure and heart rate)  
### Biological samples (2)

  - cardiovascular system
  - nervous system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- decreased heart rate  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased heart rate  
### Biological samples (4)

  - pancreas
  - nervous system
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased gastrointestinal transit  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased gastrointestinal transit  
### Biological samples (4)

  - pancreas
  - nervous system
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- analgesia  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - clinical: analgesia  
### Biological samples (2)

  - cardiovascular system
  - nervous system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- increased pupil diameter  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased pupil diameter  
### Biological samples (4)

  - pancreas
  - nervous system
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- hypothermia  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - clinical: hypothermia  
### Biological samples (2)

  - cardiovascular system
  - nervous system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- decreased blood insulin  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased blood insulin  
### Biological samples (4)

  - pancreas
  - nervous system
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- sedation  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - clinical: sedation  
### Biological samples (2)

  - cardiovascular system
  - nervous system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- increased heart rate  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased heart rate  
### Biological samples (4)

  - pancreas
  - nervous system
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)

## Off-target safety

- decreased noradrenaline release and sympathetic neurotransmission  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: decreased noradrenaline release and sympathetic neurotransmission  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- increased gastrointestinal motility  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: increased gastrointestinal motility  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- increased insulin secretion  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: increased insulin secretion  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- decreased blood pressure  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: decreased blood pressure  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- mydriasis  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: mydriasis  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- sedation  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: sedation  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- decreased heart rate  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: decreased heart rate  
### Biological samples (2)

  - cardiovascular system
  - central nervous system  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- receptor binding  
### Studies

  - biochemical: NVS\_GPCR\_hAdra2A, is one of one assay component(s) measured or calculated from the NVS\_GPCR\_hAdra2A assay. It is designed to make measurements of radioligand binding, a form of binding reporter, as detected with scintillation counting signals by Filter-based radiodetection technology.  
### Biological samples

  - cell-free  
Evidence source  
Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data)

## Related records

### Trials (4,132)

- : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic
- : Vascular Function in Health and Disease
- "Efficacy and Safety of Brimonidine Tartrate Preservative-Free Formulation in Adults With Ocular Redness"
- "Extended" (Alternate Day) Antipsychotic Dosing
- "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat
- "The Effect Of Subcutaneous Epinephrine Dosage On Blood Loss In Surgical Incision"
- \[11C\]Yohimbine PET Study of alpha2-AR
- 0.01% and 0.025% Atropine Eye Drops Combined Auricular Acupoint Stimulation on Myopia Control and Corneal Endothelium Change
- 0.6 vs. 1.2 mg Atropine Together With Neostigmine 2.5 mg on Heart Rate in Patient Receiving Muscle Relaxant
- 1/2-MC4R Genotype and Pediatric Antipsychotic Drug- Induced Weight Gain
- 10 Vs.15 mcg Norepinephrine Bolus in Severe Maternal Hypotension During Cesarean Delivery
- 15 mg Mirtazapine Orally Disintegrating Tablets, Fasting
- 15 mg Mirtazapine Orally Disintegrating Tablets, Non-Fasting
- 15 Month Study for Adults Who Have Been Diagnosed With Schizophrenia and Incarcerated
- 18F-DOPA PET to Elucidate the Antidepressant Mechanism of Lurasidone in Bipolar Disorder
- 24-hour IOP-lowering Effect of Brimonidine 0.1%
- 24-hr Intraocular Pressure Control With SIMBRINZA ®
- 28-30 Month Study Comparing Paliperidone Palmitate With Oral Risperidone for Treating Adults Diagnosed With Schizophrenia Within the Past 5 Years
- 4"S" - Seasonal Symptoms Suppression Study
- 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis

### Drugs (87)

- Alseroxylon Adrenergic receptor alpha antagonist
- Apomorphine
- Apraclonidine Adrenergic receptor alpha-2 agonist
- Apraclonidine hydrochloride Adrenergic receptor alpha-2 agonist
- Atipamezole
- Atropine
- Aviptadil Adrenergic receptor alpha antagonist
- Brimonidine Adrenergic receptor alpha-2 agonist
- Brimonidine tartrate Adrenergic receptor alpha-2 agonist
- Bromocriptine
- Cabergoline
- Celiprolol Adrenergic receptor alpha-2 antagonist
- Celiprolol hydrochloride Adrenergic receptor alpha-2 antagonist
- Chlorpromazine
- Clonidine Adrenergic receptor alpha-2 agonist
- Clonidine hydrochloride Adrenergic receptor alpha-2 agonist
- Detomidine
- Dexmedetomidine Adrenergic receptor alpha-2 agonist
- Dexmedetomidine hydrochloride Adrenergic receptor alpha-2 agonist
- Dipivefrin Adrenergic receptor agonist

---

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