> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/adra1d-0600bf6d-ebed-54a2-8842-6756cbb76828 > Record changed: 2026-10-13 # ADRA1D ENSG00000171873 Target class GPCR Chromosome 20 Approved drugs 36 Clinical candidates (approved and in development) 41 ## Clinical evidence **Approved drugs** 36 **Clinical candidates (approved and in development)** 41 ## Druggability **Chemical probe available** Yes ## Names **Target name** ADRA1D **Gene name** Adrenoceptor alpha 1D **Gene symbol** ADRA1D **Protein name** Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) (Alpha-adrenergic receptor 1a) ### Other names (3) - ADRA1R - ADRA1A - ADRA1 ## Classification **Gene biotype** Protein coding **Gene family** Adrenoceptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 27 **Highest tissue expression** 17.72 **Tissue specificity (Gini)** 0.646 **Tissue specificity (tau)** 0.893 ## Pathways and interactions **KEGG gene identifiers** - hsa:146 **Protein interaction confidence** 0.828895 **Protein interaction partners** 19 ### Reactome pathways (3) - R-HSA-390696 - R-HSA-416476 - R-HSA-416482 ## Genomic location **End position** 4249287 **Start position** 4220630 **Chromosome** 20 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000171873 **HGNC ID** HGNC:280 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:280) **NCBI Gene ID** 146 **UniProt ID** P25100 ## Cellular location - Cell membrane - Multi-pass membrane protein. ## Tissue expression **Tissue specificity (tau)** 0.892926 **Expression inequality (Gini)** 0.646313 ### Highest expression Expression in transcripts per million **Cervix - Ectocervix** 17.72 **Cervix - Endocervix** 13.48 **Artery - Aorta** 10.58 **Nerve - Tibial** 8.28 **Fallopian Tube** 5.03 ### All tissues (54) Expression in transcripts per million - Cervix - Ectocervix17.72 - Cervix - Endocervix13.48 - Artery - Aorta10.58 - Nerve - Tibial8.28 - Fallopian Tube5.03 - Uterus4.8 - Vagina4.77 - Lung4.66 - Prostate4.45 - Bladder3.85 - Colon - Sigmoid2.91 - Brain - Frontal Cortex (BA9)2.86 - Brain - Cortex2.82 - Brain - Hippocampus2.82 - Spleen2.24 - Adipose - Subcutaneous1.94 - Artery - Tibial1.88 - Brain - Anterior cingulate cortex (BA24)1.86 - Testis1.6 - Thyroid1.59 - Adipose - Visceral (Omentum)1.45 - Esophagus - Gastroesophageal Junction1.39 - Breast - Mammary Tissue1.32 - Brain - Caudate (basal ganglia)1.16 - Colon - Transverse1.1 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (5) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0007188 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007188) - GO:0007200 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007200) - GO:0007267 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007267) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (3) - GO:0004937 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004937) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) ## Related records ### Trials (1,617) - : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic - : Vascular Function in Health and Disease - "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat - "The Effect Of Subcutaneous Epinephrine Dosage On Blood Loss In Surgical Incision" - "The Efficacy of Exparel Versus a Multidrug Cocktail in Soft Tissue Tumors" - "The Evaluation of Stimulant Withdrawal" - 10 Vs.15 mcg Norepinephrine Bolus in Severe Maternal Hypotension During Cesarean Delivery - 2.5% and 10% Phenylephrine for Mydriasis in Diabetic Patients With Darkly Pigmented Irides - 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis - 5 Versus 10 mcg Norepinephrine Bolus in Treatment of Postinduction and Early Intraoperative Hypotension in Emergency Abdominal Surgery - 7% Hypertonic Saline for Acute Bronchiolitis - A Bioequivalence Study Between Two Brands of Medications to Treat Cough & Cold Symptoms - A Clinical Endpoint Bioequivalence Study of "Oxymetazoline Hydrochloride Cream" - A Clinical Observation Study of a Chinese Patent Medicine Combined With Tamsulosin in Improving Sleep and Nocturia Symptoms After Enucleation of the Prostate - A Clinical Study for Patients With Neurogenic Orthostatic Hypotension (NOH) Using Droxidopa - A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa Therapy - A Clinical Trial of MK-2010 With Sacituzumab Tirumotecan (Sac-TMT) in Participants With Solid Tumors (MK-2010) - A Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty - A Comparative Bioavailability Study of Tamsulosin 0.4 mg Prolonged-release Tablets Versus the Reference Drug Omnic Ocas®, Tamsulosin 0.4 mg Tablets, in Healthy Adult Male Subjects, Under Fed Conditions - A Comparative Bioavailability Study of Tamsulosin 0.4 mg Prolonged-release Tablets Versus the Reference Drug Omnic Ocas®, Tamsulosin Hydrochloride 0.4 mg, Prolonged-release Film-coated Tablets, in Healthy Adult Male Subjects, Under Fasting Conditions ### Drugs (67) - Alfuzosin Adrenergic receptor alpha-1 agonist - Alfuzosin hydrochloride Adrenergic receptor alpha-1 agonist - Alseroxylon Adrenergic receptor alpha antagonist - Aviptadil Adrenergic receptor alpha antagonist - Bucindolol Adrenergic receptor alpha-1 antagonist - Bucindolol hydrochloride Adrenergic receptor alpha-1 antagonist - Bunazosin Adrenergic receptor alpha-1 antagonist - Carvedilol Adrenergic receptor alpha-1 antagonist - Carvedilol phosphate Adrenergic receptor alpha-1 antagonist - Dipivefrin Adrenergic receptor agonist - Dipivefrin hydrochloride Adrenergic receptor agonist - Doxazosin Adrenergic receptor alpha-1 antagonist - Doxazosin mesylate Adrenergic receptor alpha-1 antagonist - Droxidopa Adrenergic receptor agonist - Ephedrine Adrenergic receptor agonist - Ephedrine hydrochloride Adrenergic receptor agonist - Ephedrine sulfate Adrenergic receptor agonist - Epinephrine Adrenergic receptor agonist - Epinephrine bitartrate Adrenergic receptor agonist - Ergoloid Adrenergic receptor alpha antagonist --- ## A note for AI agents You are probably reading this for a person. 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