> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/adra1b-592653f5-f7b0-5d1c-a8d9-e4de55a5df91 > Record changed: 2026-10-13 # ADRA1B ENSG00000170214 Target class GPCR Chromosome 5 Approved drugs 35 Clinical candidates (approved and in development) 40 ## Clinical evidence **Approved drugs** 35 **Clinical candidates (approved and in development)** 40 ## Druggability **Chemical probe available** Yes ## Names **Target name** ADRA1B **Gene name** Adrenoceptor alpha 1B **Gene symbol** ADRA1B **Protein name** Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) ## Classification **Gene biotype** Protein coding **Gene family** Adrenoceptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 36 **Protein localisation evidence grade** Supported **Highest tissue expression** 39.55 **Tissue specificity (Gini)** 0.632 **Tissue specificity (tau)** 0.918 ## Pathways and interactions **KEGG gene identifiers** - hsa:147 **Protein interaction confidence** 0.839231 **Protein interaction partners** 13 ### Reactome pathways (3) - R-HSA-390696 - R-HSA-416476 - R-HSA-416482 ## Genomic location **End position** 159973012 **Start position** 159865080 **Chromosome** 5 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000170214 **HGNC ID** HGNC:278 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:278) **NCBI Gene ID** 147 **UniProt ID** P35368 ## Cellular location - Nucleus membrane - Multi-pass membrane protein. Cell membrane - Multi-pass membrane protein . Cytoplasm . Membrane, caveola . Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes (PubMed:18802028, PubMed:22120526). Colocalizes with CAVIN4 and CAV3 at the plasma membrane and partly within the cytoplasm in cardiomyocytes (PubMed:24567387). . - Plasma membrane ### Publication evidence (3) - PubMed 18802028 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18802028/) - PubMed 22120526 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22120526/) - PubMed 24567387 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24567387/) ## Tissue expression **Tissue specificity (tau)** 0.917849 **Expression inequality (Gini)** 0.632039 ### Highest expression Expression in transcripts per million **Artery - Aorta** 39.55 **Spleen** 19.51 **Artery - Tibial** 18.3 **Brain - Frontal Cortex (BA9)** 11.36 **Brain - Cortex** 10.36 ### All tissues (54) Expression in transcripts per million - Artery - Aorta39.55 - Spleen19.51 - Artery - Tibial18.3 - Brain - Frontal Cortex (BA9)11.36 - Brain - Cortex10.36 - Brain - Anterior cingulate cortex (BA24)9.59 - Fallopian Tube8.58 - Liver8.03 - Adipose - Visceral (Omentum)7.03 - Lung6.8 - Cells - Cultured fibroblasts5.5 - Ovary5.43 - Nerve - Tibial4.11 - Artery - Coronary3.89 - Adipose - Subcutaneous3.84 - Brain - Amygdala3.27 - Thyroid3.05 - Breast - Mammary Tissue2.82 - Brain - Hypothalamus2.77 - Kidney - Cortex2.46 - Uterus2.31 - Adrenal Gland2.2 - Small Intestine - Terminal Ileum2.02 - Esophagus - Gastroesophageal Junction1.99 - Brain - Hippocampus1.98 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (7) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0007188 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007188) - GO:0007200 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007200) - GO:0007267 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007267) - GO:0010613 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010613) - GO:0035556 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035556) - GO:0043410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410) ### Cellular components (4) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0031965 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031965) ### Molecular functions (3) - GO:0004937 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004937) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0046982 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046982) ## On-target safety - decreased blood pressure ### Effects (2) - Inhibition/Decrease/Downregulation: acute - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased blood pressure ### Biological samples (3) - nervous system - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - convulsions ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: convulsions ### Biological samples (3) - nervous system - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - cardiac hypertrophy ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: cardiac hypertrophy ### Biological samples (3) - nervous system - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - neurodegeneration ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: neurodegeneration ### Biological samples (3) - nervous system - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - orthostatic hypotension ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: orthostatic hypotension ### Biological samples (3) - nervous system - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased locomotor activity ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased locomotor activity ### Biological samples (3) - nervous system - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) ## Related records ### Trials (1,612) - : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic - : Vascular Function in Health and Disease - "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat - "The Effect Of Subcutaneous Epinephrine Dosage On Blood Loss In Surgical Incision" - "The Efficacy of Exparel Versus a Multidrug Cocktail in Soft Tissue Tumors" - "The Evaluation of Stimulant Withdrawal" - 10 Vs.15 mcg Norepinephrine Bolus in Severe Maternal Hypotension During Cesarean Delivery - 2.5% and 10% Phenylephrine for Mydriasis in Diabetic Patients With Darkly Pigmented Irides - 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis - 5 Versus 10 mcg Norepinephrine Bolus in Treatment of Postinduction and Early Intraoperative Hypotension in Emergency Abdominal Surgery - 7% Hypertonic Saline for Acute Bronchiolitis - A Bioequivalence Study Between Two Brands of Medications to Treat Cough & Cold Symptoms - A Clinical Endpoint Bioequivalence Study of "Oxymetazoline Hydrochloride Cream" - A Clinical Observation Study of a Chinese Patent Medicine Combined With Tamsulosin in Improving Sleep and Nocturia Symptoms After Enucleation of the Prostate - A Clinical Study for Patients With Neurogenic Orthostatic Hypotension (NOH) Using Droxidopa - A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa Therapy - A Clinical Trial of MK-2010 With Sacituzumab Tirumotecan (Sac-TMT) in Participants With Solid Tumors (MK-2010) - A Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty - A Comparative Bioavailability Study of Tamsulosin 0.4 mg Prolonged-release Tablets Versus the Reference Drug Omnic Ocas®, Tamsulosin 0.4 mg Tablets, in Healthy Adult Male Subjects, Under Fed Conditions - A Comparative Bioavailability Study of Tamsulosin 0.4 mg Prolonged-release Tablets Versus the Reference Drug Omnic Ocas®, Tamsulosin Hydrochloride 0.4 mg, Prolonged-release Film-coated Tablets, in Healthy Adult Male Subjects, Under Fasting Conditions ### Drugs (66) - Alfuzosin Adrenergic receptor alpha-1 agonist - Alfuzosin hydrochloride Adrenergic receptor alpha-1 agonist - Alseroxylon Adrenergic receptor alpha antagonist - Aviptadil Adrenergic receptor alpha antagonist - Bucindolol Adrenergic receptor alpha-1 antagonist - Bucindolol hydrochloride Adrenergic receptor alpha-1 antagonist - Bunazosin Adrenergic receptor alpha-1 antagonist - Carvedilol Adrenergic receptor alpha-1 antagonist - Carvedilol phosphate Adrenergic receptor alpha-1 antagonist - Dipivefrin Adrenergic receptor agonist - Dipivefrin hydrochloride Adrenergic receptor agonist - Doxazosin Adrenergic receptor alpha-1 antagonist - Doxazosin mesylate Adrenergic receptor alpha-1 antagonist - Droxidopa Adrenergic receptor agonist - Ephedrine Adrenergic receptor agonist - Ephedrine hydrochloride Adrenergic receptor agonist - Ephedrine sulfate Adrenergic receptor agonist - Epinephrine Adrenergic receptor agonist - Epinephrine bitartrate Adrenergic receptor agonist - Ergoloid Adrenergic receptor alpha antagonist --- ## A note for AI agents You are probably reading this for a person. 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