ADRA1B
ENSG00000170214
Target class
GPCR
Chromosome
5
Approved drugs
35
Clinical candidates (approved and in development)
40
- Approved drugs
- 35
- Clinical candidates (approved and in development)
- 40
- Chemical probe available
- Yes
- Target name
- ADRA1B
- Gene name
- Adrenoceptor alpha 1B
- Gene symbol
- ADRA1B
- Protein name
- Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor)
- Gene biotype
- Protein coding
- Gene family
- Adrenoceptors
- Target class
- GPCR
- Target type
- Human gene
- Tissues expressed in
- 36
- Protein localisation evidence grade
- Supported
- Highest tissue expression
- 39.55
- Tissue specificity (Gini)
- 0.632
- Tissue specificity (tau)
- 0.918
- KEGG gene identifiers
- hsa:147
- Protein interaction confidence
- 0.839231
- Protein interaction partners
- 13
- R-HSA-390696
- R-HSA-416476
- R-HSA-416482
- End position
- 159973012
- Start position
- 159865080
- Chromosome
- 5
- Strand
- Forward
- Nucleus membrane
- Multi-pass membrane protein. Cell membrane
- Multi-pass membrane protein . Cytoplasm . Membrane, caveola . Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes (PubMed:18802028, PubMed:22120526). Colocalizes with CAVIN4 and CAV3 at the plasma membrane and partly within the cytoplasm in cardiomyocytes (PubMed:24567387). .
- Plasma membrane
- PubMed 18802028
- PubMed 22120526
- PubMed 24567387
- Tissue specificity (tau)
- 0.917849
- Expression inequality (Gini)
- 0.632039
Expression in transcripts per million
- Artery - Aorta
- 39.55
- Spleen
- 19.51
- Artery - Tibial
- 18.3
- Brain - Frontal Cortex (BA9)
- 11.36
- Brain - Cortex
- 10.36
Expression in transcripts per million
- Artery - Aorta39.55
- Spleen19.51
- Artery - Tibial18.3
- Brain - Frontal Cortex (BA9)11.36
- Brain - Cortex10.36
- Brain - Anterior cingulate cortex (BA24)9.59
- Fallopian Tube8.58
- Liver8.03
- Adipose - Visceral (Omentum)7.03
- Lung6.8
- Cells - Cultured fibroblasts5.5
- Ovary5.43
- Nerve - Tibial4.11
- Artery - Coronary3.89
- Adipose - Subcutaneous3.84
- Brain - Amygdala3.27
- Thyroid3.05
- Breast - Mammary Tissue2.82
- Brain - Hypothalamus2.77
- Kidney - Cortex2.46
- Uterus2.31
- Adrenal Gland2.2
- Small Intestine - Terminal Ileum2.02
- Esophagus - Gastroesophageal Junction1.99
- Brain - Hippocampus1.98
And 29 more, listed on the interactive page.
- GO:0007186
- GO:0007188
- GO:0007200
- GO:0007267
- GO:0010613
- GO:0035556
- GO:0043410
- GO:0005634
- GO:0005737
- GO:0005886
- GO:0031965
- GO:0004937
- GO:0005515
- GO:0046982
decreased blood pressure
- Inhibition/Decrease/Downregulation: acute
- Activation/Increase/Upregulation: acute
Studies
- preclinical: decreased blood pressure
- nervous system
- renal
- cardiovascular
PubMed 28216264convulsions
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: convulsions
- nervous system
- renal
- cardiovascular
PubMed 28216264cardiac hypertrophy
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: cardiac hypertrophy
- nervous system
- renal
- cardiovascular
PubMed 28216264neurodegeneration
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: neurodegeneration
- nervous system
- renal
- cardiovascular
PubMed 28216264orthostatic hypotension
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: orthostatic hypotension
- nervous system
- renal
- cardiovascular
PubMed 28216264decreased locomotor activity
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: decreased locomotor activity
- nervous system
- renal
- cardiovascular
PubMed 28216264
Related records
Trials (1,612)
- : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic
- : Vascular Function in Health and Disease
- "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat
- "The Effect Of Subcutaneous Epinephrine Dosage On Blood Loss In Surgical Incision"
- "The Efficacy of Exparel Versus a Multidrug Cocktail in Soft Tissue Tumors"
- "The Evaluation of Stimulant Withdrawal"
- 10 Vs.15 mcg Norepinephrine Bolus in Severe Maternal Hypotension During Cesarean Delivery
- 2.5% and 10% Phenylephrine for Mydriasis in Diabetic Patients With Darkly Pigmented Irides
- 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis
- 5 Versus 10 mcg Norepinephrine Bolus in Treatment of Postinduction and Early Intraoperative Hypotension in Emergency Abdominal Surgery
- 7% Hypertonic Saline for Acute Bronchiolitis
- A Bioequivalence Study Between Two Brands of Medications to Treat Cough & Cold Symptoms
- A Clinical Endpoint Bioequivalence Study of "Oxymetazoline Hydrochloride Cream"
- A Clinical Observation Study of a Chinese Patent Medicine Combined With Tamsulosin in Improving Sleep and Nocturia Symptoms After Enucleation of the Prostate
- A Clinical Study for Patients With Neurogenic Orthostatic Hypotension (NOH) Using Droxidopa
- A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa Therapy
- A Clinical Trial of MK-2010 With Sacituzumab Tirumotecan (Sac-TMT) in Participants With Solid Tumors (MK-2010)
- A Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty
- A Comparative Bioavailability Study of Tamsulosin 0.4 mg Prolonged-release Tablets Versus the Reference Drug Omnic Ocas®, Tamsulosin 0.4 mg Tablets, in Healthy Adult Male Subjects, Under Fed Conditions
- A Comparative Bioavailability Study of Tamsulosin 0.4 mg Prolonged-release Tablets Versus the Reference Drug Omnic Ocas®, Tamsulosin Hydrochloride 0.4 mg, Prolonged-release Film-coated Tablets, in Healthy Adult Male Subjects, Under Fasting Conditions
Drugs (66)
- Alfuzosin Adrenergic receptor alpha-1 agonist
- Alfuzosin hydrochloride Adrenergic receptor alpha-1 agonist
- Alseroxylon Adrenergic receptor alpha antagonist
- Aviptadil Adrenergic receptor alpha antagonist
- Bucindolol Adrenergic receptor alpha-1 antagonist
- Bucindolol hydrochloride Adrenergic receptor alpha-1 antagonist
- Bunazosin Adrenergic receptor alpha-1 antagonist
- Carvedilol Adrenergic receptor alpha-1 antagonist
- Carvedilol phosphate Adrenergic receptor alpha-1 antagonist
- Dipivefrin Adrenergic receptor agonist
- Dipivefrin hydrochloride Adrenergic receptor agonist
- Doxazosin Adrenergic receptor alpha-1 antagonist
- Doxazosin mesylate Adrenergic receptor alpha-1 antagonist
- Droxidopa Adrenergic receptor agonist
- Ephedrine Adrenergic receptor agonist
- Ephedrine hydrochloride Adrenergic receptor agonist
- Ephedrine sulfate Adrenergic receptor agonist
- Epinephrine Adrenergic receptor agonist
- Epinephrine bitartrate Adrenergic receptor agonist
- Ergoloid Adrenergic receptor alpha antagonist