> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/adra1a-baadd40e-5daa-510f-a895-13afc1b2fd89 > Record changed: 2026-10-13 # ADRA1A ENSG00000120907 Target class GPCR Chromosome 8 Approved drugs 39 Clinical candidates (approved and in development) 46 ## Clinical evidence **Approved drugs** 39 **Clinical candidates (approved and in development)** 46 ## Druggability **Chemical probe available** Yes ## Names **Other names** - ADRA1L1 **Target name** ADRA1A **Gene name** Adrenoceptor alpha 1A **Gene symbol** ADRA1A **Previous gene symbols** - ADRA1C **Protein name** Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c) ## Classification **Gene biotype** Protein coding **Gene family** Adrenoceptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 13 **Protein localisation evidence grade** Approved **Highest tissue expression** 14.14 **Tissue specificity (Gini)** 0.631 **Tissue specificity (tau)** 0.948 ## Pathways and interactions **KEGG gene identifiers** - hsa:148 **Protein interaction confidence** 0.856333 **Protein interaction partners** 12 ### Reactome pathways (3) - R-HSA-390696 - R-HSA-416476 - R-HSA-416482 ## Genomic location **End position** 26867278 **Start position** 26748150 **Chromosome** 8 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000120907 **HGNC ID** HGNC:277 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:277) **NCBI Gene ID** 148 **UniProt ID** P35348 ## Cellular location - Nucleus membrane - Multi-pass membrane protein. Cell membrane - Multi-pass membrane protein . Cytoplasm . Membrane, caveola . Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes (PubMed:18802028, PubMed:22120526). Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes (PubMed:18802028, PubMed:22120526). Colocalizes with CAVIN4 and CAV3 at the plasma membrane and partly within the cytoplasm in cardiomyocytes (PubMed:24567387). . - Cytosol ### Publication evidence (3) - PubMed 18802028 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18802028/) - PubMed 22120526 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22120526/) - PubMed 24567387 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24567387/) ## Tissue expression **Tissue specificity (tau)** 0.947786 **Expression inequality (Gini)** 0.631079 ### Highest expression Expression in transcripts per million **Liver** 14.14 **Lung** 3.75 **Spleen** 3.27 **Adipose - Visceral (Omentum)** 2.27 **Heart - Left Ventricle** 2.27 ### All tissues (54) Expression in transcripts per million - Liver14.14 - Lung3.75 - Spleen3.27 - Adipose - Visceral (Omentum)2.27 - Heart - Left Ventricle2.27 - Prostate2.23 - Adipose - Subcutaneous2.04 - Breast - Mammary Tissue1.65 - Brain - Cerebellum1.34 - Artery - Tibial1.2 - Colon - Sigmoid1.19 - Brain - Anterior cingulate cortex (BA24)1.18 - Brain - Cortex1.07 - Brain - Frontal Cortex (BA9)0.98 - Testis0.95 - Small Intestine - Terminal Ileum0.88 - Esophagus - Gastroesophageal Junction0.82 - Uterus0.79 - Brain - Amygdala0.77 - Brain - Hippocampus0.73 - Brain - Hypothalamus0.69 - Brain - Caudate (basal ganglia)0.58 - Cervix - Endocervix0.58 - Colon - Transverse0.57 - Minor Salivary Gland0.56 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (10) - GO:0006915 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006915) - GO:0006939 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006939) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0007200 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007200) - GO:0007267 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007267) - GO:0008285 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008285) - GO:0010613 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010613) - GO:0035556 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035556) - GO:0043410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410) ### Cellular components (5) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0031965 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031965) ### Molecular functions (3) - GO:0004937 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004937) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0046982 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046982) ## On-target safety - increased blood pressure ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased blood pressure ### Biological samples - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - cardiac arrhythmia ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: cardiac arrhythmia ### Biological samples - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - smooth-muscle contraction (prostate in particular, effects on the lower urinary tract) ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: smooth-muscle contraction (prostate in particular, effects on the lower urinary tract) ### Biological samples (2) - cardiovascular system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - dizziness ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: dizziness ### Biological samples - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - orthostatic hypotension ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: orthostatic hypotension ### Biological samples - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - chronic heart failure ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: chronic heart failure ### Biological samples - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - arrhythmia ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: arrhythmia ### Biological samples (2) - cardiovascular system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - increased cardiac contractility ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased cardiac contractility ### Biological samples - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - cardiac positive ionotropy ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: cardiac positive ionotropy ### Biological samples (2) - cardiovascular system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - vascular hypertrophy ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: vascular hypertrophy ### Biological samples - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased blood pressure ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased blood pressure ### Biological samples - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - orthostatic hypotension ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: orthostatic hypotension ### Biological samples (2) - cardiovascular system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - sexual function ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: sexual function ### Biological samples (2) - cardiovascular system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - blood pressure events ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: blood pressure events ### Biological samples (2) - cardiovascular system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - increased pupil diameter ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased pupil diameter ### Biological samples - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - retrograde ejaculation ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: retrograde ejaculation ### Biological samples - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased heart rate ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased heart rate ### Biological samples - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) ## Off-target safety - orthostatic hypotension ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: orthostatic hypotension ### Biological samples (3) - cardiovascular system - central nervous system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - impact on various aspects of sexual function ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: impact on various aspects of sexual function ### Biological samples (3) - cardiovascular system - central nervous system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - smooth muscle contraction ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: smooth muscle contraction ### Biological samples (3) - cardiovascular system - central nervous system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - mydriasis ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: mydriasis ### Biological samples (3) - cardiovascular system - central nervous system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - decreased smooth muscle tone ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: decreased smooth muscle tone ### Biological samples (3) - cardiovascular system - central nervous system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - increased blood pressure ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: increased blood pressure ### Biological samples (3) - cardiovascular system - central nervous system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - dizziness ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: dizziness ### Biological samples (3) - cardiovascular system - central nervous system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - decreased insulin release ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: decreased insulin release ### Biological samples (3) - cardiovascular system - central nervous system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - potential for arrhythmia ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: potential for arrhythmia ### Biological samples (3) - cardiovascular system - central nervous system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - cardiac positive ionotropy ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: cardiac positive ionotropy ### Biological samples (3) - cardiovascular system - central nervous system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - increased heart rate ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: increased heart rate ### Biological samples (3) - cardiovascular system - central nervous system - gastrointestinal PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) ## Related records ### Trials (1,641) - : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic - : Vascular Function in Health and Disease - "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat - "The Effect Of Subcutaneous Epinephrine Dosage On Blood Loss In Surgical Incision" - "The Efficacy of Exparel Versus a Multidrug Cocktail in Soft Tissue Tumors" - "The Evaluation of Stimulant Withdrawal" - 10 Vs.15 mcg Norepinephrine Bolus in Severe Maternal Hypotension During Cesarean Delivery - 2.5% and 10% Phenylephrine for Mydriasis in Diabetic Patients With Darkly Pigmented Irides - 4% Articaine and 2% Lidocaine by Intraligamentary Technique in Irreversible Pulpitis - 5 Versus 10 mcg Norepinephrine Bolus in Treatment of Postinduction and Early Intraoperative Hypotension in Emergency Abdominal Surgery - 7% Hypertonic Saline for Acute Bronchiolitis - A Bioequivalence Study Between Two Brands of Medications to Treat Cough & Cold Symptoms - A Clinical Endpoint Bioequivalence Study of "Oxymetazoline Hydrochloride Cream" - A Clinical Observation Study of a Chinese Patent Medicine Combined With Tamsulosin in Improving Sleep and Nocturia Symptoms After Enucleation of the Prostate - A Clinical Study for Patients With Neurogenic Orthostatic Hypotension (NOH) Using Droxidopa - A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa Therapy - A Clinical Trial of MK-2010 With Sacituzumab Tirumotecan (Sac-TMT) in Participants With Solid Tumors (MK-2010) - A Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty - A Comparative Bioavailability Study of Tamsulosin 0.4 mg Prolonged-release Tablets Versus the Reference Drug Omnic Ocas®, Tamsulosin 0.4 mg Tablets, in Healthy Adult Male Subjects, Under Fed Conditions - A Comparative Bioavailability Study of Tamsulosin 0.4 mg Prolonged-release Tablets Versus the Reference Drug Omnic Ocas®, Tamsulosin Hydrochloride 0.4 mg, Prolonged-release Film-coated Tablets, in Healthy Adult Male Subjects, Under Fasting Conditions ### Drugs (74) - Alfuzosin Adrenergic receptor alpha-1 agonist - Alfuzosin hydrochloride Adrenergic receptor alpha-1 agonist - Alseroxylon Adrenergic receptor alpha antagonist - Aviptadil Adrenergic receptor alpha antagonist - Bucindolol Adrenergic receptor alpha-1 antagonist - Bucindolol hydrochloride Adrenergic receptor alpha-1 antagonist - Bunazosin Adrenergic receptor alpha-1 antagonist - Carvedilol Adrenergic receptor alpha-1 antagonist - Carvedilol phosphate Adrenergic receptor alpha-1 antagonist - Dabuzalgron Alpha-1a adrenergic receptor partial agonist - Dapiprazole Alpha-1a adrenergic receptor antagonist - Dapiprazole hydrochloride Alpha-1a adrenergic receptor antagonist - Dipivefrin Adrenergic receptor agonist - Dipivefrin hydrochloride Adrenergic receptor agonist - Doxazosin Adrenergic receptor alpha-1 antagonist - Doxazosin mesylate Adrenergic receptor alpha-1 antagonist - Droxidopa Adrenergic receptor agonist - Ephedrine Adrenergic receptor agonist - Ephedrine hydrochloride Adrenergic receptor agonist - Ephedrine sulfate Adrenergic receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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