> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/adora3-e4ae62bc-7545-585e-a904-620858df7712 > Record changed: 2026-11-04 # ADORA3 ENSG00000282608 Target class GPCR Chromosome 1 Approved drugs 7 Clinical candidates (approved and in development) 10 ## Clinical evidence **Approved drugs** 7 **Clinical candidates (approved and in development)** 10 ## Druggability **Chemical probe available** Yes ## Names **Target name** ADORA3 **Gene name** Adenosine A3 receptor **Gene symbol** ADORA3 **Protein name** Adenosine receptor A3 ### Other names (2) - AD026 - A3AR ## Classification **Gene biotype** Protein coding **Gene family** Adenosine receptors|V-set domain containing **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 43 **Highest tissue expression** 14.82 **Tissue specificity (Gini)** 0.415 **Tissue specificity (tau)** 0.821 ## Pathways and interactions **KEGG gene identifiers** - hsa:140 **Protein interaction confidence** 0.9148 **Protein interaction partners** 5 ### Reactome pathways (2) - R-HSA-417973 - R-HSA-418594 ## Genomic location **End position** 111503633 **Start position** 111499429 **Chromosome** 1 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000282608 **HGNC ID** HGNC:268 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:268) **NCBI Gene ID** 140 **UniProt ID** P0DMS8 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (2) - PubMed 38627384 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38627384/) - PubMed 40825947 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/40825947/) ## Tissue expression **Tissue specificity (tau)** 0.820576 **Expression inequality (Gini)** 0.415358 ### Highest expression Expression in transcripts per million **Brain - Spinal cord (cervical c-1)** 14.82 **Nerve - Tibial** 8.48 **Adrenal Gland** 7.99 **Small Intestine - Terminal Ileum** 6.63 **Brain - Substantia nigra** 5.75 ### All tissues (54) Expression in transcripts per million - Brain - Spinal cord (cervical c-1)14.82 - Nerve - Tibial8.48 - Adrenal Gland7.99 - Small Intestine - Terminal Ileum6.63 - Brain - Substantia nigra5.75 - Spleen4.97 - Bladder4.92 - Brain - Hypothalamus4.47 - Cervix - Endocervix4.44 - Artery - Aorta4.16 - Artery - Coronary4.09 - Colon - Transverse3.94 - Lung3.89 - Fallopian Tube3.83 - Adipose - Subcutaneous3.79 - Brain - Hippocampus3.5 - Brain - Amygdala3.49 - Esophagus - Gastroesophageal Junction3.47 - Colon - Sigmoid3.44 - Adipose - Visceral (Omentum)3.43 - Esophagus - Muscularis3.24 - Prostate3.14 - Minor Salivary Gland2.58 - Brain - Caudate (basal ganglia)2.52 - Breast - Mammary Tissue2.48 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (8) - GO:0006954 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006954) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007190 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007190) - GO:0007193 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007193) - GO:0008016 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008016) - GO:0008285 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008285) - GO:0009611 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009611) - GO:0030336 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030336) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions - GO:0001609 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001609) ## On-target safety - angiogenesis ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: angiogenesis ### Biological samples (2) - cardiovascular system - immune Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - decreased convulsions ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased convulsions ### Biological samples (2) - nervous system - respiratory PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - interference with the regulation of cell growth (inferred by author) ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: interference with the regulation of cell growth (inferred by author) ### Biological samples (2) - cardiovascular system - immune Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - cell proliferation ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: cell proliferation ### Biological samples (2) - cardiovascular system - immune Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - decreased locomotor activity ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased locomotor activity ### Biological samples (2) - nervous system - respiratory PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased bronchoconstriction ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased bronchoconstriction ### Biological samples (2) - nervous system - respiratory PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased convulsions ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased convulsions ### Biological samples (2) - nervous system - respiratory PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased pain ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased pain ### Biological samples (2) - nervous system - respiratory PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - myocardial ischemia (inferred by author) ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: myocardial ischemia (inferred by author) ### Biological samples (2) - cardiovascular system - immune Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - cell necrosis ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: cell necrosis ### Biological samples (2) - cardiovascular system - immune Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - antiischaemic (cardioprotective) ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: antiischaemic (cardioprotective) ### Biological samples (2) - cardiovascular system - immune Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - hypertension (inferred by author) ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: hypertension (inferred by author) ### Biological samples (2) - cardiovascular system - immune Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - proischemic (cerebral) ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: proischemic (cerebral) ### Biological samples (2) - cardiovascular system - immune Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - hypotension ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: hypotension ### Biological samples (2) - cardiovascular system - immune Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - immunosuppression ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: immunosuppression ### Biological samples (2) - cardiovascular system - immune Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - proinflammatory effects (inferred by author) ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: proinflammatory effects (inferred by author) ### Biological samples (2) - cardiovascular system - immune Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) ## Related records ### Trials (642) - "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat - 12-Week, Double-Blind, Placebo-Controlled Study of 20 and 60 mg/Day Istradefylline in Parkinson's Disease Patients on Levodopa/Carbodopa - 12-Week, Double-Blind, Placebo-Controlled, Randomized Study of the Efficacy of 40 mg/Day KW-6002 in Parkinson's Disease Patients on Levodopa/Carbidopa - A 12-week Randomized Study to Evaluate Oral Istradefylline in Subjects With Moderate to Severe Parkinson's Disease - A Clinical Study in Patients With Chronic Idiopathic Thrombocytopenic Purpura in R788 - A Comparison of Nicardipine and Labetalol for Blood Pressure Control in Intensive Care Patients After Hemorrhagic Stroke Brain Surgery - A Comparison Study of Apadenoson and Adenosine to Treadmill Exercise Stress. - A DDI Study to Assess the Effect of INC280 on the PK of Midazolam and Caffeine in Patients With cMET-dysregulated Advanced Solid Tumors - A Dental Pain Study Comparing The Analgesic Efficacy Of Ibuprofen/Caffeine - A Dose Finding Study of Preladenant (SCH 420814) for the Treatment of Parkinson's Disease (PD) in Japanese Patients (P06402) - A Dose Titration Study to Assess the Effects of SAR407899 in Patients With MVA and/or Persistent Stable Angina Despite Angiographically Successful PCI - A Drug Interaction Study of KW-6356 With Midazolam, Caffeine, or Rosuvastatin - A Drug-Drug Interaction (DDI) Study of LY3437943 in Obese Participants - A Drug-Drug Interaction Study of Abiraterone Acetate Plus Prednisone With Dextromethorphan and Theophylline in Patients With Metastatic Castration-Resistant Prostate Cancer - A Long Term Study to Assess the Safety of Fostamatinib in Patients in Asia With Rheumatoid Arthritis - A Long-Term, Safety Study With a Flexible Dose Range of KW-6002 in Patients With Motor Response Complications on Levodopa/Carbidopa Therapy - A Phase 1-2 Study of CF102 in Patients With Advanced Hepatocellular Carcinoma - A Phase 1/2 Study of CF102 in Patients With Chronic Hepatitis C Genotype 1 - A Phase 2b Study of Istradefylline (KW-6002) for the Treatment of Parkinson's Disease in Patients Taking Levodopa - A Phase 3 Study in Moderate-to-Severe Plaque Psoriasis With Piclidenoson to Study Safety and Efficacy ### Drugs (33) - Adenosine Adenosine receptor agonist - Aminophylline Adenosine receptor antagonist - Apadenoson - Binodenoson - [Caffeine](https://trialight.com/data/asset/caffeine-4062cceb-b322-4d67-b5b1-c5c5913c8897.md) Adenosine receptor antagonist - Caffeine citrate Adenosine receptor antagonist - Derenofylline - Dexniguldipine - FK453 - Flavone - Fostamatinib - GS 6201 - GS-9667 - Istradefylline - LUF-5981 - LUF-6000 - LUF-6096 - Namodenoson Adenosine A3 receptor agonist - Nicardipine - Oxtriphylline Adenosine receptor antagonist --- ## A note for AI agents You are probably reading this for a person. 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