> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/adora2b-32c9c6eb-5ed0-573e-adb1-915dc447c1a4 > Record changed: 2026-11-04 # ADORA2B ENSG00000170425 Target class GPCR Chromosome 17 Approved drugs 8 Clinical candidates (approved and in development) 13 ## Clinical evidence **Approved drugs** 8 **Clinical candidates (approved and in development)** 13 ## Druggability **Chemical probe available** Yes ## Names **Target name** ADORA2B **Gene name** Adenosine A2b receptor **Gene symbol** ADORA2B **Protein name** Adenosine receptor A2b ## Classification **Gene biotype** Protein coding **Gene family** Adenosine receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 40 **Protein localisation evidence grade** Supported **Highest tissue expression** 15.56 **Tissue specificity (Gini)** 0.533 **Tissue specificity (tau)** 0.773 ## Pathways and interactions **KEGG gene identifiers** - hsa:136 **Protein interaction confidence** 0.82375 **Protein interaction partners** 8 ### Reactome pathways (4) - R-HSA-417973 - R-HSA-418555 - R-HSA-5683826 - R-HSA-9660821 ## Genomic location **End position** 15975746 **Start position** 15945130 **Chromosome** 17 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000170425 **HGNC ID** HGNC:264 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:264) **NCBI Gene ID** 136 **UniProt ID** P29275 ## Cellular location - Cell membrane - Multi-pass membrane protein. - Plasma membrane ## Tissue expression **Tissue specificity (tau)** 0.773391 **Expression inequality (Gini)** 0.532617 ### Highest expression Expression in transcripts per million **Skin - Not Sun Exposed (Suprapubic)** 15.56 **Esophagus - Mucosa** 13.8 **Skin - Sun Exposed (Lower leg)** 12.87 **Vagina** 11.92 **Cells - Cultured fibroblasts** 11.64 ### All tissues (54) Expression in transcripts per million - Skin - Not Sun Exposed (Suprapubic)15.56 - Esophagus - Mucosa13.8 - Skin - Sun Exposed (Lower leg)12.87 - Vagina11.92 - Cells - Cultured fibroblasts11.64 - Brain - Anterior cingulate cortex (BA24)10.65 - Brain - Cortex9.93 - Colon - Transverse9.01 - Brain - Frontal Cortex (BA9)8.88 - Brain - Nucleus accumbens (basal ganglia)8.2 - Brain - Caudate (basal ganglia)6.61 - Brain - Cerebellum5.57 - Brain - Amygdala5.57 - Brain - Putamen (basal ganglia)5.45 - Brain - Hippocampus4.34 - Lung4.01 - Bladder3.99 - Pituitary3.85 - Brain - Cerebellar Hemisphere3.47 - Colon - Sigmoid3.39 - Testis3.06 - Brain - Hypothalamus2.96 - Prostate2.79 - Small Intestine - Terminal Ileum2.45 - Fallopian Tube2.16 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0007190 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007190) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## On-target safety - decreased pain ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased pain ### Biological samples (2) - immune - peripheral nervous system PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased/decreased inflammation ### Effects (2) - Activation/Increase/Upregulation: acute - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased/decreased inflammation ### Biological samples (2) - immune - peripheral nervous system PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) ## Related records ### Trials (753) - "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat - "Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients" - 12-Week, Double-Blind, Placebo-Controlled Study of 20 and 60 mg/Day Istradefylline in Parkinson's Disease Patients on Levodopa/Carbodopa - 12-Week, Double-Blind, Placebo-Controlled, Randomized Study of the Efficacy of 40 mg/Day KW-6002 in Parkinson's Disease Patients on Levodopa/Carbidopa - A 12-week Randomized Study to Evaluate Oral Istradefylline in Subjects With Moderate to Severe Parkinson's Disease - A DDI Study to Assess the Effect of INC280 on the PK of Midazolam and Caffeine in Patients With cMET-dysregulated Advanced Solid Tumors - A Dental Pain Study Comparing The Analgesic Efficacy Of Ibuprofen/Caffeine - A Dose Finding Study of Preladenant (SCH 420814) for the Treatment of Parkinson's Disease (PD) in Japanese Patients (P06402) - A Dose Titration Study to Assess the Effects of SAR407899 in Patients With MVA and/or Persistent Stable Angina Despite Angiographically Successful PCI - A Drug Interaction Study of KW-6356 With Midazolam, Caffeine, or Rosuvastatin - A Drug-Drug Interaction (DDI) Study of LY3437943 in Obese Participants - A Drug-Drug Interaction Study of Abiraterone Acetate Plus Prednisone With Dextromethorphan and Theophylline in Patients With Metastatic Castration-Resistant Prostate Cancer - A Drug-Drug Interaction Study to Evaluate the Effect of Itraconazole on the Pharmacokinetic Profile of Etrumadenant in Healthy Adult Participants - A Long-Term, Safety Study With a Flexible Dose Range of KW-6002 in Patients With Motor Response Complications on Levodopa/Carbidopa Therapy - A Phase 1 Clinical Study of AZD4635 in Patients With Advanced Solid Malignancies - A Phase 1-2 Study of CF102 in Patients With Advanced Hepatocellular Carcinoma - A Phase 1/2 Study of CF102 in Patients With Chronic Hepatitis C Genotype 1 - A Phase 2 Study to Evaluate the Triplet Combination of Pemetrexed Plus AB928 (Etrumadenant) + AB122 (Zimberelimab) in Patients With Previously Treated Advanced or Metastatic MTAP Deficient Urothelial Carcinoma - A Phase 2b Study of Istradefylline (KW-6002) for the Treatment of Parkinson's Disease in Patients Taking Levodopa - A Phase 3 Study in Moderate-to-Severe Plaque Psoriasis With Piclidenoson to Study Safety and Efficacy ### Drugs (31) - Adenosine Adenosine receptor agonist - Aminophylline Adenosine receptor antagonist - Binodenoson - [Caffeine](https://trialight.com/data/asset/caffeine-4062cceb-b322-4d67-b5b1-c5c5913c8897.md) Adenosine receptor antagonist - Caffeine citrate Adenosine receptor antagonist - Defibrotide Adenosine A2 receptor agonist - Derenofylline - Etrumadenant Adenosine A2b receptor antagonist - FK453 - GS 6201 Adenosine A2b receptor antagonist - GS-9667 - Imaradenant - Istradefylline - LAS101057 Adenosine A2b receptor antagonist - LUF-5981 - Namodenoson - Oxtriphylline Adenosine receptor antagonist - Pentoxifylline Adenosine A2 receptor antagonist - Piclidenoson - Preladenant --- ## A note for AI agents You are probably reading this for a person. 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