> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/adora1-76475566-fcd4-566c-bfcd-c5beda4b1425 > Record changed: 2026-10-13 # ADORA1 ENSG00000163485 Target class GPCR Chromosome 1 Approved drugs 7 Clinical candidates (approved and in development) 24 ## Clinical evidence **Approved drugs** 7 **Clinical candidates (approved and in development)** 24 ## Druggability **Chemical probe available** Yes ## Names **Other names** - RDC7 **Target name** ADORA1 **Gene name** Adenosine A1 receptor **Gene symbol** ADORA1 **Protein name** Adenosine receptor A1 ## Classification **Gene biotype** Protein coding **Gene family** Adenosine receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 32 **Protein localisation evidence grade** Supported **Highest tissue expression** 43.18 **Tissue specificity (Gini)** 0.671 **Tissue specificity (tau)** 0.798 ## Pathways and interactions **KEGG gene identifiers** - hsa:134 **Protein interaction confidence** 0.819833 **Protein interaction partners** 18 ### Reactome pathways (2) - R-HSA-417973 - R-HSA-418594 ## Genomic location **End position** 203167407 **Start position** 203090654 **Chromosome** 1 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000163485 **HGNC ID** HGNC:262 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:262) **NCBI Gene ID** 134 **UniProt ID** P30542 ## Cellular location - Cell membrane - Multi-pass membrane protein. - Plasma membrane ### Publication evidence - PubMed 27134041 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27134041/) ## Tissue expression **Tissue specificity (tau)** 0.79843 **Expression inequality (Gini)** 0.671196 ### Highest expression Expression in transcripts per million **Brain - Spinal cord (cervical c-1)** 43.18 **Brain - Frontal Cortex (BA9)** 39.61 **Brain - Cortex** 36.67 **Testis** 35.52 **Brain - Substantia nigra** 31 ### All tissues (54) Expression in transcripts per million - Brain - Spinal cord (cervical c-1)43.18 - Brain - Frontal Cortex (BA9)39.61 - Brain - Cortex36.67 - Testis35.52 - Brain - Substantia nigra31 - Brain - Putamen (basal ganglia)30.76 - Brain - Caudate (basal ganglia)29.27 - Brain - Amygdala27.56 - Brain - Nucleus accumbens (basal ganglia)27.1 - Brain - Hippocampus27.05 - Brain - Cerebellum26.78 - Brain - Anterior cingulate cortex (BA24)26.62 - Brain - Cerebellar Hemisphere26.56 - Brain - Hypothalamus20.82 - Heart - Atrial Appendage7.72 - Spleen6.47 - Pancreas6.43 - Kidney - Cortex5.71 - Skin - Sun Exposed (Lower leg)4.73 - Breast - Mammary Tissue3.76 - Minor Salivary Gland3.56 - Heart - Left Ventricle3.55 - Thyroid3.21 - Adipose - Visceral (Omentum)3.16 - Skin - Not Sun Exposed (Suprapubic)2.84 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (7) - GO:0006909 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006909) - GO:0006954 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006954) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007267 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007267) - GO:0007399 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007399) - GO:0014074 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0014074) - GO:0097190 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097190) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## On-target safety - bronchoconstriction ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: bronchoconstriction ### Biological samples (3) - cardiovascular system - nervous system - renal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - induction of sleep ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: induction of sleep ### Biological samples (3) - cardiovascular system - nervous system - renal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - natriuresis ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: natriuresis ### Biological samples (3) - cardiovascular system - nervous system - renal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - death ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: death ### Biological samples (3) - nervous system - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - heart failure ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: heart failure ### Biological samples (3) - nervous system - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - diuresis ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: diuresis ### Biological samples (3) - cardiovascular system - nervous system - renal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - atrioventricular block ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: atrioventricular block ### Biological samples (3) - nervous system - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - convulsions ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: convulsions ### Biological samples (3) - nervous system - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased urinary sodium excretion ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased urinary sodium excretion ### Biological samples (3) - nervous system - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - bradycardia ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: bradycardia ### Biological samples (3) - cardiovascular system - nervous system - renal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - decreased pain ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased pain ### Biological samples (3) - nervous system - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - cardioprotection ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: cardioprotection ### Biological samples (3) - cardiovascular system - nervous system - renal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - decreased blood pressure ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased blood pressure ### Biological samples (3) - nervous system - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased heart rate ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased heart rate ### Biological samples (3) - nervous system - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - cardiac arrhythmia ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: cardiac arrhythmia ### Biological samples (3) - nervous system - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - vasoconstriction ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: vasoconstriction ### Biological samples (3) - cardiovascular system - nervous system - renal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - increased urine excretion ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased urine excretion ### Biological samples (3) - nervous system - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - vasodilation ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: vasodilation ### Biological samples (3) - cardiovascular system - nervous system - renal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) ## Off-target safety - receptor binding ### Studies - biochemical: NVS\_GPCR\_hAdoRA1, is one of one assay component(s) measured or calculated from the NVS\_GPCR\_hAdoRA1 assay. It is designed to make measurements of radioligand binding, a form of binding reporter, as detected with scintillation counting signals by Filter-based radiodetection technology. ### Biological samples - brain, tissue-based cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (419) - "First-in-human" Study To Assess the Safety and Tolerability of PBF-680 in Male Healthy Volunteers - "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat - A 1-year Multi-center, Prospective, Cohort Study in Patients With Chronic Obstructive Pulmonary Disease Treated With Long-acting Bronchodilator - [A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in Combination With Another Investigational Treatment Pumitamig (BNT327) and Chemotherapy, is Beneficial and Safe for Patients With Advanced Colorectal Cancer](https://trialight.com/data/trial/a-clinical-study-to-test-if-an-investigational-treatment-82b821cf-b97a-4a6b-831e-5b3b3ba12a09.md) - A Comparison of the Bioavailability of OZ439 When Delivered Directly to the Small Intestine, or Via the Oral Route - A DDI Study to Assess the Effect of INC280 on the PK of Midazolam and Caffeine in Patients With cMET-dysregulated Advanced Solid Tumors - A Dental Pain Study Comparing The Analgesic Efficacy Of Ibuprofen/Caffeine - A Dose-Escalation Study Designed to Evaluate the Tolerability, Safety, Pharmacokinetics (PK), and Efficacy of Chronic Topical Ocular Application of INO-8875 in Adults With Ocular Hypertension or Primary Open-Angle Glaucoma - A Drug Interaction Study of KW-6356 With Midazolam, Caffeine, or Rosuvastatin - A Drug-Drug Interaction (DDI) Study of LY3437943 in Obese Participants - A Drug-Drug Interaction Study of Abiraterone Acetate Plus Prednisone With Dextromethorphan and Theophylline in Patients With Metastatic Castration-Resistant Prostate Cancer - A Phase I Dose Escalation Study of Erlotinib in Combination With Theophylline - A Phase I Study of GFH312 in Healthy Chinese Subjects - A Phase II Study to Evaluate the Additivity of Trabodenoson to Latanoprost in Adults With Ocular Hypertension or Primary Open-Angle Glaucoma - A Pilot Study Into Health Pre and Post Treatment With Intravenous Aminophylline and Hydrocortisone in Severe Asthmatics - A Pilot Study to Determine the Feasibility and Utility of Implementing of the Full Scale TOM Trial - A Placebo-controlled Study to Investigate the Safety, and Pharmacokinetics of Oral GSK626616AC in Healthy Subjects - A Possible Therapeutic Role for Adenosine During Inflammation - A Randomized, Double-blind, Active Control, Parallel Group, Titration, Multicenter Study to Evaluate the Efficacy and Safety of Fimasartan - A Research Study on How UBT251 Affects Levels of Midazolam, Caffeine and Warfarin in the Blood of Participants With Excess Body Weight ### Drugs (26) - Adenosine Adenosine receptor agonist - Aminophylline Adenosine receptor antagonist - AMP579 Adenosine A1 receptor agonist - [BAY1067197](https://trialight.com/data/asset/bay1067197-e3b0d610-90a7-4624-af01-2150c15cf32f.md) Adenosine A1 receptor agonist - Caffeine Adenosine receptor antagonist - Caffeine citrate Adenosine receptor antagonist - Capadenoson Adenosine A1 receptor partial agonist - Defibrotide Adenosine A1 receptor agonist - Derenofylline Adenosine A1 receptor antagonist - FK453 Adenosine A1 receptor antagonist - GS-9667 Adenosine A1 receptor partial agonist - GW493838 Adenosine A1 receptor agonist - Naxifylline Adenosine A1 receptor antagonist - Oxtriphylline Adenosine receptor antagonist - PBF-680 Adenosine A1 receptor antagonist - Rolofylline Adenosine A1 receptor antagonist - RPR749 Adenosine A1 receptor agonist - Selodenoson Adenosine A1 receptor agonist - T-62 Adenosine A1 receptor modulator - Tecadenoson Adenosine A1 receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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