> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/adgrg3-9fdaa3f5-08ff-5293-9b78-b6cb0855e5ed > Record changed: 2026-11-04 # ADGRG3 ENSG00000182885 Target class GPCR Chromosome 16 ## Druggability **Chemical probe available** No ## Names **Target name** ADGRG3 **Gene name** Adhesion G protein-coupled receptor G3 **Gene symbol** ADGRG3 **Previous gene symbols** - GPR97 **Protein name** Adhesion G protein-coupled receptor G3 (G-protein coupled receptor 97) \[Cleaved into: Adhesion G-protein coupled receptor G3, N-terminal fragment (ADGRG3 N-terminal fragment); Adhesion G-protein coupled receptor G3, C-terminal fragment (ADGRG3 C-terminal fragment)\] ### Other names (2) - Pb99 - PGR26 ## Classification **Gene biotype** Protein coding **Gene family** Adhesion G protein-coupled receptors, subfamily G **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 28 **Highest tissue expression** 492.04 **Tissue specificity (Gini)** 0.908 **Tissue specificity (tau)** 0.992 ## Pathways and interactions **KEGG gene identifiers** - hsa:222487 **Reactome pathways** - R-HSA-6798695 **Protein interaction confidence** 0.835667 **Protein interaction partners** 3 ## Genomic location **End position** 57689378 **Start position** 57668277 **Chromosome** 16 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000182885 **HGNC ID** HGNC:13728 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:13728) **NCBI Gene ID** 222487 **UniProt ID** Q86Y34 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (2) - PubMed 22575658 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22575658/) - PubMed 33408414 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/33408414/) ## Tissue expression **Tissue specificity (tau)** 0.992359 **Expression inequality (Gini)** 0.908009 ### Highest expression Expression in transcripts per million **Whole Blood** 492.04 **Spleen** 76.57 **Lung** 28.3 **Adipose - Visceral (Omentum)** 10.73 **Thyroid** 9.98 ### All tissues (54) Expression in transcripts per million - Whole Blood492.04 - Spleen76.57 - Lung28.3 - Adipose - Visceral (Omentum)10.73 - Thyroid9.98 - Fallopian Tube8.54 - Small Intestine - Terminal Ileum6.61 - Cervix - Ectocervix5.64 - Breast - Mammary Tissue4.06 - Colon - Sigmoid3.3 - Esophagus - Muscularis2.89 - Colon - Transverse2.8 - Adipose - Subcutaneous2.79 - Esophagus - Gastroesophageal Junction2.76 - Vagina2.48 - Bladder2.36 - Cervix - Endocervix2.26 - Skin - Sun Exposed (Lower leg)1.85 - Liver1.76 - Esophagus - Mucosa1.68 - Uterus1.56 - Stomach1.53 - Skin - Not Sun Exposed (Suprapubic)1.51 - Kidney - Cortex1.46 - Prostate1.4 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0007193 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007193) - GO:0030334 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030334) ### Cellular components (3) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0035579 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035579) ### Molecular functions (2) - GO:0004930 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004930) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (111) - (CARE Network Trial - Treating Children to Prevent Exacerbations of Asthma (TREXA) - 7 Day Study of Mast Cell Inhibitor, R926112, in Patients With Symptomatic Seasonal Allergic Rhinitis - A 12-week Safety and Efficacy Study of Beclomethasone Dipropionate (80 and 160 mcg/Day) Delivered Via Breath-Actuated Inhaler (BAI) in Patients >=12 Years Old With Persistent Asthma - A Dose Ranging Study of Delayed Release Beclomethasone for Prevention of Acute Enteritis in Patients With Rectal Cancer - A Randomized Double Blind Placebo Controlled Study of the Effect of Swallowed Beclomethasone Dipropionate on Inflammatory Markers in Adult Patients With Eosinophilic Esophagitis - A Safety and Efficacy Study of Beclomethasone Dipropionate Delivered Via Breath-Actuated Inhaler (BAI) or Metered-Dose Inhaler (MDI) in Participants >=12 Years Old With Persistent Asthma - A Safety and Efficacy Study of Beclomethasone Dipropionate Delivered Via Breath-Actuated Inhaler (BAI) or Metered-Dose Inhaler (MDI) in Participants Ages 4-11 Years Old With Persistent Asthma - [A Study Comparing Efficacy, Safety and Tolerability of the Fixed Dose Triple Combination CHF 5993 With the Fixed Dose Dual Combination CHF 1535 in Subjects With COPD](https://trialight.com/data/trial/a-study-comparing-efficacy-safety-and-tolerability-of-the-9c56f08f-6d7f-440a-8b9a-37eada504345.md) - A Study Comparing the Effects of Trimbow to Fostair in COPD - A Study in Patients With Chronic Obstructive Pulmonary Disease - [A Study Testing the Superiority of CHF 1535 pMDI 800/24µg Total Daily Dose Compared With CHF 718 pMDI 800µg Total Daily Dose in Adults With Asthma on Medium or High-Dose Inhaled Corticosteroid](https://trialight.com/data/trial/a-study-testing-the-superiority-of-chf-1535-pmdi-800-24-g-1bf49299-3917-48d2-941b-8cc3e4dc928e.md) - A Study to Evaluate the Acute Bronchodilator Effect of CHF1535 NEXThaler - A Study to Investigate the Pharmacokinetics and Safety of Beclomethasone Dipropionate Administered by Breath-Actuated Inhaler and Metered-Dose Inhaler in Healthy Adults - A Study to Investigate the Pharmacokinetics, Safety and Tolerability of CHF 5993 pMDI in Subjects With Renal Impairment. - Allergic Rhinitis Changes the Sinus Microbiome - Assessment of Oxidative Stress Markers in the Upper and Lower Airways of Atopic Children Treated With Nebulized Beclomethasone - Asthma Clinical Research Network (ACRN) Trial - Long-Acting Beta Agonist Response by Genotype (LARGE) - Asthma Clinical Research Network (ACRN) Trial - Tiotropium Bromide as an Alternative to Increased Inhaled Corticosteroid in Patients Inadequately Controlled on a Lower Dose of Inhaled Corticosteroid (TALC) - Beclometasone Dipropionate and Formoterol Inhalation Aerosol for Asthma - Beclomethasone Dipropionate HFA in Adult and Adolescent Subjects With Mild to Moderate Persistent Asthma ### Drugs (1) - [Beclomethasone dipropionate](https://trialight.com/data/asset/beclomethasone-dipropionate-068d01cb-b921-4eda-85ad-1921f6683476.md) --- ## A note for AI agents You are probably reading this for a person. 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