> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/acvr2b-cb4a236d-550a-5b3c-be5a-939d03d0fc1e > Record changed: 2026-10-13 # ACVR2B ENSG00000114739 Target class Kinase Chromosome 3 Approved drugs 1 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** No ## Names **Other names** - ActR-IIB **Target name** ACVR2B **Gene name** Activin A receptor type 2B **Gene symbol** ACVR2B **Protein name** Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB) ## Classification **Gene biotype** Protein coding **Gene family** Type 2 receptor serine/threonine kinases **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 52 **Highest tissue expression** 10.52 **Tissue specificity (Gini)** 0.318 **Tissue specificity (tau)** 0.74 ## Pathways and interactions **KEGG gene identifiers** - hsa:93 **Protein interaction confidence** 0.93244 **Protein interaction partners** 50 ### Reactome pathways (4) - R-HSA-1181150 - R-HSA-1433617 - R-HSA-1502540 - R-HSA-201451 ## Genomic location **End position** 38493142 **Start position** 38453890 **Chromosome** 3 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000114739 **HGNC ID** HGNC:174 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:174) **NCBI Gene ID** 93 **UniProt ID** Q13705 ## Cellular location - Cell membrane - Single-pass type I membrane protein . ### Publication evidence - PubMed 31665064 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/31665064/) ## Tissue expression **Tissue specificity (tau)** 0.739723 **Expression inequality (Gini)** 0.318106 ### Highest expression Expression in transcripts per million **Brain - Cerebellar Hemisphere** 10.52 **Brain - Cerebellum** 10.05 **Ovary** 6.5 **Testis** 5.95 **Uterus** 5.21 ### All tissues (54) Expression in transcripts per million - Brain - Cerebellar Hemisphere10.52 - Brain - Cerebellum10.05 - Ovary6.5 - Testis5.95 - Uterus5.21 - Nerve - Tibial5.12 - Cervix - Endocervix4.96 - Adrenal Gland4.8 - Pituitary4.55 - Cervix - Ectocervix4.14 - Fallopian Tube4.05 - Thyroid3.53 - Bladder3.23 - Vagina3.11 - Colon - Sigmoid3.04 - Kidney - Medulla3.04 - Prostate2.88 - Lung2.82 - Esophagus - Gastroesophageal Junction2.66 - Brain - Frontal Cortex (BA9)2.65 - Esophagus - Muscularis2.63 - Brain - Spinal cord (cervical c-1)2.63 - Brain - Hypothalamus2.56 - Breast - Mammary Tissue2.48 - Brain - Cortex2.46 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (12) - GO:0000122 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000122) - GO:0006355 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006355) - GO:0006879 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006879) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007178 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007178) - GO:0009952 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009952) - GO:0030501 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030501) - GO:0030509 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030509) - GO:0032924 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032924) - GO:0032927 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032927) - GO:0045669 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045669) - GO:0061450 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061450) ### Cellular components (4) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0032991 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032991) - GO:0043235 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235) ### Molecular functions (4) - GO:0004674 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004674) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0016362 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016362) - GO:0019838 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019838) ## Related records ### Trials (33) - A 24-week Off-drug Extension Study in Sarcopenic Elderly Who Completed Treatment in the 6-month Core Study - A Multi-center Study to Assess the Effects of BYM338 on Skeletal Muscle in Sarcopenic Adults - A Phase 2/3 Multicenter, Controlled Trial Of rhBMP-2/CPM In Tibial Fractures - A Study of Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Participants With Obesity or Overweight With Type 2 Diabetes - A Study of Bimagrumab Alone (LY3985863) and Bimagrumab With Tirzepatide (LY900042) in Healthy Participants - A Study of rhBMP-2/CPM in Closed Fractures of the Humerus - A Study to Investigate Weight Management With Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Adults With Obesity or Overweight - An Extension Study of the Efficacy, Safety and Tolerability of BYM338 (Bimagrumab) in Patients With Sporadic Inclusion Body Myositis Who Previously Participated in the Core Study CBYM338B2203 - BMP Effect on Implant Stability and Marginal Bone Level After Immediate Placement - Bone Morphogenetic Protein-2 In Grade II Furcation Defects. - BYM338 in Chronic Obstructive Pulmonary Disease (COPD) Patients With Cachexia - Clinical Study of BYM338 for the Treatment of Unintentional Weight Loss in Patients With Cancer of the Lung or the Pancreas - Dose Range Finding Study of Bimagrumab in Sarcopenia - Effect of Recombinant Human Bone Morphogenetic Protein-2 With an Absorbable Collagen Sponge on Stability of Dental Implant: (Split Mouth Randomized Clinical Trial Study. - Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity - Efficacy and Safety of Bimagrumab/BYM338 at 52 Weeks on Physical Function, Muscle Strength, Mobility in sIBM Patients - Efficacy, Safety and Tolerability of BYM338 in Patients With Sporadic Inclusion Body Myositis - Feasibility And Safety Study Of rhBMP-2/CPM For Hip Fractures - Lateral Ridge Augmentation Using Autogenous Bone Blocks or Xenogenic Bone Block Grafts Loaded With Recombinant Human Bone Morphogenic Protein 2 - Periodontally Accelerated Osteogenic Orthodontics With BMP2 ### Drugs (2) - [Bimagrumab](https://trialight.com/data/asset/bimagrumab-0a25ca88-023e-46fb-a721-cf5c435758d7.md) Activin receptor type-2B antagonist - Dibotermin alfa Activin receptor type-2B agonist --- ## A note for AI agents You are probably reading this for a person. 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