> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/acvr1-d528a65d-e230-51af-8c67-61f171354eca > Record changed: 2026-10-13 # ACVR1 ENSG00000115170 Target class Kinase Chromosome 2 Approved drugs 4 Clinical candidates (approved and in development) 4 ## Clinical evidence **Approved drugs** 4 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 4 ## Druggability **Chemical probe available** Yes ## Names **Target name** ACVR1 **Gene name** Activin A receptor type 1 **Gene symbol** ACVR1 **Previous gene symbols** - ACVRLK2 **Protein name** Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) ### Other names (3) - SKR1 - ALK2 - ACVR1A ## Classification **Gene biotype** Protein coding **Gene family** Type 1 receptor serine/threonine kinases **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Highest tissue expression** 43.14 **Tissue specificity (Gini)** 0.368 **Tissue specificity (tau)** 0.636 ## Pathways and interactions **KEGG gene identifiers** - hsa:90 **Protein interaction confidence** 0.923522 **Protein interaction partners** 46 ## Genomic location **End position** 157876347 **Start position** 157736249 **Chromosome** 2 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000115170 **HGNC ID** HGNC:171 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:171) **NCBI Gene ID** 90 **UniProt ID** Q04771 ## Cellular location - Membrane - Single-pass type I membrane protein. ## Tissue expression **Tissue specificity (tau)** 0.635741 **Expression inequality (Gini)** 0.367595 ### Highest expression Expression in transcripts per million **Cells - Cultured fibroblasts** 43.14 **Artery - Tibial** 38.73 **Cervix - Endocervix** 38.01 **Uterus** 35.94 **Artery - Aorta** 35.89 ### All tissues (54) Expression in transcripts per million - Cells - Cultured fibroblasts43.14 - Artery - Tibial38.73 - Cervix - Endocervix38.01 - Uterus35.94 - Artery - Aorta35.89 - Thyroid34.24 - Cervix - Ectocervix32.27 - Fallopian Tube27.86 - Adipose - Subcutaneous27.61 - Ovary26.8 - Breast - Mammary Tissue26.09 - Artery - Coronary25.58 - Nerve - Tibial24.28 - Bladder24.11 - Vagina23.05 - Minor Salivary Gland22.49 - Colon - Sigmoid21.82 - Esophagus - Muscularis21.73 - Lung21.16 - Adipose - Visceral (Omentum)20.85 - Esophagus - Gastroesophageal Junction19.68 - Skin - Sun Exposed (Lower leg)17.81 - Skin - Not Sun Exposed (Suprapubic)16.71 - Pituitary15.49 - Prostate14.99 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (23) - GO:0001649 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001649) - GO:0003143 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003143) - GO:0003183 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003183) - GO:0003289 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003289) - GO:0007179 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007179) - GO:0009968 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009968) - GO:0030278 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030278) - GO:0030335 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030335) - GO:0030501 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030501) - GO:0030509 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030509) - GO:0032924 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032924) - GO:0032926 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032926) - GO:0045669 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045669) - GO:0045893 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045893) - GO:0045944 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944) - GO:0060391 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060391) - GO:0060923 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060923) - GO:0061445 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061445) - GO:0071773 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071773) - GO:1902533 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902533) - GO:2000017 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000017) - GO:2000134 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000134) - GO:2001237 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2001237) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0048179 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048179) ### Molecular functions (13) - GO:0004672 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004672) - GO:0004674 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004674) - GO:0004675 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004675) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0005524 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005524) - GO:0016361 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016361) - GO:0042803 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803) - GO:0045296 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045296) - GO:0046332 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046332) - GO:0048185 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048185) - GO:0050431 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050431) - GO:0098821 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098821) - GO:1990782 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990782) ## Related records ### Trials (96) - A Phase 1 Study of SB1518 for the Treatment of Advanced Lymphoid Malignancies - A Phase 1/2 Study of Oral SB1518 in Subjects With Chronic Idiopathic Myelofibrosis - A Phase 1/2 Study of SB1518 for the Treatment of Advanced Myeloid Malignancies - A Phase 2 Study to Evaluate the Safety and Efficacy of Pacritinib in Relapsed or Refractory Waldenström Macroglobulinemia - A Phase 2/3 Multicenter, Controlled Trial Of rhBMP-2/CPM In Tibial Fractures - A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis - A Phase I/II GVHD Prevention Trial Combining Pacritinib With Sirolimus-Based Immune Suppression - A Phase I/II Study of Gilteritinib and Momelotinib for Patients With Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia - A Phase II Non-Controlled, Open-Label, Efficacy, Safety, Pharmacokinetic, and Pharmacodynamic Study of Pacritinib in Myelofibrosis - A Safety and Efficacy Study of SB1518 for the Treatment of Advanced Lymphoid Malignancies - A Single Arm, Phase Ib/II Trial of Single Agent Pacritinib in Patients With 1q21.3 Amplified Solid Tumors Enriching for Interleukin-1 Receptor-associated Kinase 1 Pathway Activation (PAIR) - A Study Evaluating the Efficacy and Safety of Momelotinib in Participants With Vacuoles, E1-enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) Syndrome - [A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms](https://trialight.com/data/trial/a-study-of-jnj-88549968-for-the-treatment-of-calreticulin-ba23876c-8a4f-4f22-9a4b-adfedd20019f.md) - A Study of Momelotinib in Participants With Low-risk Myelodysplastic Syndrome - A Study of Momelotinib Versus Danazol in Symptomatic and Anemic Myelofibrosis Participants (MOMENTUM) - A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis - A Study of rhBMP-2/CPM in Closed Fractures of the Humerus - A Study of Selinexor Monotherapy in Subjects With JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia - A Study to Assess the Effectiveness and Safety of Pacritinib in Patients With VEXAS Syndrome (PAXIS) - BMP Effect on Implant Stability and Marginal Bone Level After Immediate Placement ### Drugs (6) - Dibotermin alfa Activin receptor type-1 agonist - Eptotermin alfa Activin receptor type-1 agonist - [Momelotinib](https://trialight.com/data/asset/momelotinib-d384d174-93c9-4c16-bc43-4bc528bdef0d.md) Activin receptor type-1 inhibitor - Momelotinib dihydrochloride monohydrate Activin receptor type-1 inhibitor - Pacritinib Activin receptor type-1 inhibitor - Pacritinib citrate Activin receptor type-1 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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