> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/acp3-b29db11d-3254-5e1f-946c-a5065d1382c6
> Record changed: 2026-10-13

# ACP3

ENSG00000014257

Target class

Enzyme

Chromosome

3

Approved drugs

0

Clinical candidates (approved and in development)

1

## Clinical evidence

**Approved drugs**

0

**Clinical candidates (approved and in development)**

1

## Druggability

**Chemical probe available**

No

## Names

**Target name**

ACP3

**Gene name**

Acid phosphatase 3

**Gene symbol**

ACP3

**Previous gene symbols**

- ACPP

**Protein name**

Prostatic acid phosphatase (PAP) (EC 3.1.3.2) (5'-nucleotidase) (5'-NT) (EC 3.1.3.5) (Acid phosphatase 3) (Ecto-5'-nucleotidase) (Protein tyrosine phosphatase ACP3) (EC 3.1.3.48) (Thiamine monophosphatase) (TMPase) \[Cleaved into: PAPf39\]

### Other names (3)

- ACP-3
- PAP
- TM-PAP

## Classification

**Gene biotype**

Protein coding

**Gene family**

Acid phosphatases

**Target class**

Enzyme

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

18

**Highest tissue expression**

1,281.35

**Tissue specificity (Gini)**

0.962

**Tissue specificity (tau)**

0.998

## Pathways and interactions

**KEGG gene identifiers**

- hsa:55

**Reactome pathways**

- R-HSA-6798695

**Protein interaction confidence**

0.8549

**Protein interaction partners**

10

## Genomic location

**End position**

132368302

**Start position**

132317369

**Chromosome**

3

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000014257

**HGNC ID**

HGNC:125

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:125)

**NCBI Gene ID**

55

**UniProt ID**

P15309

## Cellular location

- \[Isoform 1\]: Secreted .
- SUBCELLULAR LOCATION: \[Isoform 2\]: Cell membrane
- Single-pass type I membrane protein . Lysosome membrane
- Single-pass type I membrane protein . Nucleus . Cytoplasm, cytosol . Note=Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles (PubMed:17638863). Colocalizes with LAMP2 on the lysosome membrane (PubMed:17897319). .

### Publication evidence (3)

- PubMed 17638863  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17638863/)
- PubMed 17897319  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17897319/)
- PubMed 20498373  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20498373/)

## Tissue expression

**Tissue specificity (tau)**

0.9981

**Expression inequality (Gini)**

0.961814

### Highest expression

Expression in transcripts per million

**Prostate**

1,281.35

**Esophagus - Mucosa**

40.63

**Skin - Not Sun Exposed (Suprapubic)**

16.51

**Skin - Sun Exposed (Lower leg)**

16.46

**Vagina**

9.84

### All tissues (54)

Expression in transcripts per million

- Prostate1,281.35
- Esophagus - Mucosa40.63
- Skin - Not Sun Exposed (Suprapubic)16.51
- Skin - Sun Exposed (Lower leg)16.46
- Vagina9.84
- Kidney - Medulla6.85
- Minor Salivary Gland6.09
- Whole Blood5.23
- Kidney - Cortex3.84
- Lung2.41
- Adrenal Gland2.15
- Thyroid1.53
- Spleen1.5
- Colon - Transverse1.25
- Small Intestine - Terminal Ileum1.07
- Ovary1.05
- Stomach1.05
- Testis1.04
- Fallopian Tube0.91
- Pancreas0.82
- Cells - Cultured fibroblasts0.82
- Bladder0.8
- Adipose - Visceral (Omentum)0.63
- Breast - Mammary Tissue0.56
- Pituitary0.5

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (3)

- GO:0046085  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046085)
- GO:0051930  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051930)
- GO:0060168  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060168)

### Cellular components (6)

- GO:0005576  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576)
- GO:0005634  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)
- GO:0005765  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005765)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0035577  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035577)
- GO:0070062  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062)

### Molecular functions (9)

- GO:0003993  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003993)
- GO:0004725  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004725)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0008253  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008253)
- GO:0016791  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016791)
- GO:0042802  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802)
- GO:0042803  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803)
- GO:0052642  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0052642)
- GO:0060090  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060090)

## Related records

### Trials (35)

- 177^Lu-PSMA-617 in Combination With Sipuleucel-T for the Treatment of Metastatic Castration-Resistant Prostate Cancer
- A Multicenter Trial Enrolling Men With Advanced Prostate Cancer Who Are to Receive Combination Radiation and Sipuleucel-T
- A Registry of Sipuleucel-T Therapy in Men With Advanced Prostate Cancer
- A Study of Sipuleucel-T With Administration of Enzalutamide in Men With Metastatic Castrate-Resistant Prostate Cancer
- APC8015 and Bevacizumab in Treating Patients With Prostate Cancer
- Clinical Study of Atezolizumab (Anti-PD-L1) and Sipuleucel-T in Patients With Asymptomatic or Minimally Symptomatic Metastatic Castrate Resistant Prostate Cancer
- Concurrent vs. Sequential Sipuleucel-T & Abiraterone Treatment in Men With Metastatic Castrate Resistant Prostate Cancer
- Dendreon Lymph Node Biopsy in Metastatic Castrate-Resistant Prostate Cancer
- Docetaxel Followed by Provenge in Metastatic Prostate Cancer
- Immune Monitoring Protocol in Men With Prostate Cancer Enrolled in a Clinical Trial of Sipuleucel-T
- Immunotherapy With APC8015 (Sipuleucel-T, Provenge) for Asymptomatic, Metastatic, Hormone-Refractory Prostate Cancer
- Men With Metastatic Castrate-Resistant Prostate Cancer Treated With Either Sipuleucel-T (Provenge®), Abiraterone Acetate (Zytiga®) or Enzalutamide (Xtandi®) Undergoing Cardiopulmonary EXercise Testing
- [Metastatic Castrate-Resistant Prostate Cancer Subjects Treated With PROVENGE® + One Infusion of Sipuleucel-T](https://trialight.com/data/trial/metastatic-castrate-resistant-prostate-cancer-subjects-ff63bfc2-2908-49ce-84aa-db6971576f43.md)
- Open Label Study of Sipuleucel-T in Metastatic Prostate Cancer
- Open- Label Trial of Sipuleucel-T Administered to Active Surveillance Patients for Newly Diagnosed Prostate Cancer
- Phase II Study of Sipuleucel-T and Indoximod for Patients With Refractory Metastatic Prostate Cancer
- Provenge Followed by Docetaxel in Castration-Resistant Prostate Cancer
- PROvenge Treatment and Early Cancer Treatment
- Provenge With or Without pTVG-HP DNA Booster Vaccine in Prostate Cancer
- Provenge® (Sipuleucel-T) Active Cellular Immunotherapy Treatment of Metastatic Prostate Cancer After Failing Hormone Therapy

### Drugs (1)

- [Sipuleucel-T](https://trialight.com/data/asset/sipuleucel-t-d0bfb0cd-9239-4171-adcf-a740613aa90e.md) Prostatic acid phosphatase binding agent

---

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