> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/ache-d2ea998f-6390-5915-be6d-023f0963eeba
> Record changed: 2026-11-04

# ACHE

ENSG00000087085

Target class

Enzyme

Chromosome

7

Approved drugs

19

Clinical candidates (approved and in development)

23

## Clinical evidence

**Approved drugs**

19

**Clinical candidates (approved and in development)**

23

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

ACHE

**Gene name**

Acetylcholinesterase (Yt blood group)

**Gene symbol**

ACHE

**Previous gene symbols**

- YT

**Protein name**

Acetylcholinesterase (AChE) (EC 3.1.1.7)

## Classification

**Gene biotype**

Protein coding

**Gene family**

Blood group antigens|Cholinesterase family

**Target class**

Enzyme

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

49

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

71.17

**Tissue specificity (Gini)**

0.627

**Tissue specificity (tau)**

0.879

## Pathways and interactions

**KEGG gene identifiers**

- hsa:43

**Protein interaction confidence**

0.822033

**Protein interaction partners**

30

### Reactome pathways (3)

- R-HSA-112311
- R-HSA-1483191
- R-HSA-422085

## Genomic location

**End position**

100897022

**Start position**

100889994

**Chromosome**

7

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000087085

**HGNC ID**

HGNC:108

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:108)

**NCBI Gene ID**

43

**UniProt ID**

P22303

## Cellular location

- Synapse . Secreted . Cell membrane
- Peripheral membrane protein .
- SUBCELLULAR LOCATION: \[Isoform T\]: Nucleus. Note=Only observed in apoptotic nuclei.
- SUBCELLULAR LOCATION: \[Isoform H\]: Cell membrane
- Lipid-anchor, GPI-anchor
- Extracellular side .
- Golgi apparatus
- Vesicles

### Publication evidence (2)

- PubMed 11985878  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11985878/)
- PubMed 1748670  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1748670/)

## Tissue expression

**Tissue specificity (tau)**

0.879017

**Expression inequality (Gini)**

0.626809

### Highest expression

Expression in transcripts per million

**Brain - Cerebellum**

71.17

**Brain - Hypothalamus**

68.56

**Brain - Cerebellar Hemisphere**

63.81

**Brain - Nucleus accumbens (basal ganglia)**

25.14

**Muscle - Skeletal**

22.4

### All tissues (54)

Expression in transcripts per million

- Brain - Cerebellum71.17
- Brain - Hypothalamus68.56
- Brain - Cerebellar Hemisphere63.81
- Brain - Nucleus accumbens (basal ganglia)25.14
- Muscle - Skeletal22.4
- Brain - Caudate (basal ganglia)22.05
- Brain - Putamen (basal ganglia)18.9
- Brain - Substantia nigra18.73
- Brain - Frontal Cortex (BA9)18.56
- Brain - Cortex18.32
- Brain - Anterior cingulate cortex (BA24)11.66
- Pituitary10.91
- Prostate9.66
- Small Intestine - Terminal Ileum8.69
- Cervix - Endocervix8.18
- Brain - Amygdala7.64
- Brain - Hippocampus7.6
- Testis7.39
- Colon - Transverse7.25
- Brain - Spinal cord (cervical c-1)6.83
- Colon - Sigmoid6.56
- Minor Salivary Gland6.55
- Ovary6.28
- Heart - Atrial Appendage6.16
- Uterus5.62

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (8)

- GO:0002076  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002076)
- GO:0006581  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006581)
- GO:0007155  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007155)
- GO:0007399  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007399)
- GO:0007416  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007416)
- GO:0032223  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032223)
- GO:0042982  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042982)
- GO:0050714  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050714)

### Cellular components (7)

- GO:0005576  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576)
- GO:0005794  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0016020  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020)
- GO:0031594  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031594)
- GO:0045202  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045202)
- GO:0048471  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048471)

### Molecular functions (10)

- GO:0001540  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001540)
- GO:0003990  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003990)
- GO:0004104  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004104)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0005518  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005518)
- GO:0016787  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016787)
- GO:0017171  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017171)
- GO:0042166  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042166)
- GO:0042803  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803)
- GO:0043236  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043236)

## On-target safety

- increased salivation  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased salivation  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- death  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: death  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- bronchoconstriction  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: bronchoconstriction  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- muscle relaxation  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: muscle relaxation  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- coma  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: coma  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased defecation  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased defecation  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- vomiting  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: vomiting  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- foot drop  
### Effects

  - Inhibition/Decrease/Downregulation: chronic  
### Studies

  - preclinical: foot drop  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased urine excretion  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased urine excretion  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased pupil diameter  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased pupil diameter  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- cognitive deficit  
### Effects

  - Inhibition/Decrease/Downregulation: chronic  
### Studies

  - preclinical: cognitive deficit  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- Decrease, Population growth rate  
### Effects

  - Inhibition/Decrease/Downregulation  
### Studies

  - cell-based  
### Biological samples

  - nervous system  
Evidence source  
Source: [aopwiki.org](https://aopwiki.org/aops/16)
- apnea  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: apnea  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- peripheral neuropathy  
### Effects

  - Inhibition/Decrease/Downregulation: chronic  
### Studies

  - preclinical: peripheral neuropathy  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- autonomic dysfunction  
### Effects

  - Inhibition/Decrease/Downregulation: chronic  
### Studies

  - preclinical: autonomic dysfunction  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- mood change  
### Effects

  - Inhibition/Decrease/Downregulation: chronic  
### Studies

  - preclinical: mood change  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- ataxia  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: ataxia  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- lacrimation  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: lacrimation  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- tingling/weakness in limbs  
### Effects

  - Inhibition/Decrease/Downregulation: chronic  
### Studies

  - preclinical: tingling/weakness in limbs  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased then decreased heart rate  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased then decreased heart rate  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased bronchial secretions  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased bronchial secretions  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- convulsions  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: convulsions  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- diarrhea  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: diarrhea  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- Increased Mortality  
### Effects

  - Inhibition/Decrease/Downregulation  
### Studies

  - cell-based  
### Biological samples

  - nervous system  
Evidence source  
Source: [aopwiki.org](https://aopwiki.org/aops/16)
- increased then decreased blood pressure  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased then decreased blood pressure  
### Biological samples (4)

  - nervous system
  - respiratory
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)

And 1 more, listed on the interactive page.

## Off-target safety

- increased respiratory secretions  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: increased respiratory secretions  
### Biological samples (3)

  - cardiovascular system
  - pulmonary
  - gastrointestinal  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- decreased gastrointestinal motility  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased gastrointestinal motility  
### Biological samples (3)

  - cardiovascular system
  - pulmonary
  - gastrointestinal  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- decreased heart rate  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: decreased heart rate  
### Biological samples (3)

  - cardiovascular system
  - pulmonary
  - gastrointestinal  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- decreased blood pressure  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: decreased blood pressure  
### Biological samples (3)

  - cardiovascular system
  - pulmonary
  - gastrointestinal  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- regulation of catalytic activity  
### Studies

  - biochemical: NVS\_ENZ\_hAChE, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hAChE assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with absorbance signals by Colorimetric technology.  
### Biological samples

  - cell-free  
Evidence source  
Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data)
- bronchoconstriction  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: bronchoconstriction  
### Biological samples (3)

  - cardiovascular system
  - pulmonary
  - gastrointestinal  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- increased gastrointestinal motility  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: increased gastrointestinal motility  
### Biological samples (3)

  - cardiovascular system
  - pulmonary
  - gastrointestinal  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)

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### Drugs (41)

- Acotiamide Acetylcholinesterase inhibitor
- Acotiamide hydrochloride Acetylcholinesterase inhibitor
- Ambenonium Acetylcholinesterase inhibitor
- Ambenonium chloride Acetylcholinesterase inhibitor
- Benzgalantamine Acetylcholinesterase inhibitor
- Benzgalantamine gluconate Acetylcholinesterase inhibitor
- Demecarium Acetylcholinesterase inhibitor
- Demecarium bromide Acetylcholinesterase inhibitor
- Distigmine Acetylcholinesterase inhibitor
- Distigmine bromide Acetylcholinesterase inhibitor
- Donepezil Acetylcholinesterase inhibitor
- [Donepezil hydrochloride](https://trialight.com/data/asset/donepezil-hydrochloride-3e847c97-f6d7-496b-a78e-b6a9e46fd819.md) Acetylcholinesterase inhibitor
- Echothiophate Acetylcholinesterase inhibitor
- Echothiophate iodide Acetylcholinesterase inhibitor
- Edrophonium Acetylcholinesterase inhibitor
- Edrophonium chloride Acetylcholinesterase inhibitor
- Galantamine Acetylcholinesterase inhibitor
- Galantamine hydrobromide Acetylcholinesterase inhibitor
- Hexafluorenium Acetylcholinesterase inhibitor
- Hexafluorenium bromide Acetylcholinesterase inhibitor

---

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