ACE
ENSG00000159640
Target class
Enzyme
Chromosome
17
Approved drugs
14
Clinical candidates (approved and in development)
17
- Approved drugs
- 14
- ClinGen gene-disease validity
- Definitive
- Clinical candidates (approved and in development)
- 17
- Chemical probe available
- No
- Target name
- ACE
- Gene name
- Angiotensin I converting enzyme
- Gene symbol
- ACE
- Previous gene symbols
- DCP1
- Protein name
- Angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (CD antigen CD143) [Cleaved into: Angiotensin-converting enzyme, soluble form]
- ACE1
- CD143
- Gene biotype
- Protein coding
- Gene family
- CD molecules
- Target class
- Enzyme
- Target type
- Human gene
- Tissues expressed in
- 49
- Protein localisation evidence grade
- Approved
- Highest tissue expression
- 112.34
- Tissue specificity (Gini)
- 0.637
- Tissue specificity (tau)
- 0.941
- KEGG gene identifiers
- hsa:1636
- Reactome pathways
- R-HSA-2022377
- Protein interaction confidence
- 0.817875
- Protein interaction partners
- 56
- End position
- 63498380
- Start position
- 63477058
- Chromosome
- 17
- Strand
- Forward
- Cell membrane
- Single-pass type I membrane protein . Cytoplasm . Note=Detected in both cell membrane and cytoplasm in neurons. .
- SUBCELLULAR LOCATION: [Angiotensin-converting enzyme, soluble form]: Secreted .
- SUBCELLULAR LOCATION: [Isoform Testis-specific]: Cell membrane
- Single-pass type I membrane protein . Secreted . Note=The testis-specific isoform can be cleaved before the transmembrane region, releasing a soluble form. .
- Vesicles
- PubMed 12386153
- PubMed 10769174
- PubMed 11274151
- PubMed 7499427
- PubMed 8253769
- PubMed 1668266
- PubMed 8626443
- Tissue specificity (tau)
- 0.941127
- Expression inequality (Gini)
- 0.636915
Expression in transcripts per million
- Testis
- 112.34
- Small Intestine - Terminal Ileum
- 64.78
- Lung
- 38.96
- Thyroid
- 22.32
- Adipose - Subcutaneous
- 16.06
Expression in transcripts per million
- Testis112.34
- Small Intestine - Terminal Ileum64.78
- Lung38.96
- Thyroid22.32
- Adipose - Subcutaneous16.06
- Pituitary12.48
- Cervix - Ectocervix12.33
- Colon - Transverse10.07
- Prostate9.54
- Breast - Mammary Tissue9.19
- Adipose - Visceral (Omentum)8.79
- Minor Salivary Gland8.69
- Cervix - Endocervix8.67
- Brain - Caudate (basal ganglia)8.16
- Brain - Putamen (basal ganglia)6.51
- Cells - Cultured fibroblasts6.4
- Brain - Nucleus accumbens (basal ganglia)5.71
- Uterus5.26
- Esophagus - Gastroesophageal Junction5.16
- Nerve - Tibial5.1
- Esophagus - Muscularis4.94
- Vagina4.85
- Artery - Coronary4.49
- Skin - Sun Exposed (Lower leg)4.23
- Colon - Sigmoid4
And 29 more, listed on the interactive page.
- GO:0001822
- GO:0001974
- GO:0002003
- GO:0002019
- GO:0002474
- GO:0003081
- GO:0006508
- GO:0010814
- GO:0010815
- GO:0019229
- GO:0032943
- GO:0042445
- GO:0042447
- GO:0043171
- GO:0050435
- GO:0050482
- GO:0060177
- GO:0060218
- GO:0097746
- GO:1902033
- GO:0005576
- GO:0005764
- GO:0005768
- GO:0005886
- GO:0009897
- GO:0070062
- GO:0004175
- GO:0004222
- GO:0008233
- GO:0008237
- GO:0008238
- GO:0008240
- GO:0008241
- GO:0008270
- GO:0031404
- GO:0031434
- GO:0031711
- GO:0051019
- GO:0070573
increased urine excretion
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: increased urine excretion
- renal
- cardiovascular
PubMed 28216264gastrointestinal hemorrhagic erosion/ulcer
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: gastrointestinal hemorrhagic erosion/ulcer
- renal
- cardiovascular
PubMed 28216264interstitial cell infiltration
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: interstitial cell infiltration
- renal
- cardiovascular
PubMed 28216264decreased blood pressure
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: decreased blood pressure
- renal
- cardiovascular
PubMed 28216264increased risk spontaneous abortion
Effects
- Inhibition/Decrease/Downregulation: developmental toxicity
Studies
- preclinical: increased risk spontaneous abortion
- renal
- cardiovascular
PubMed 28216264proximal tubular degeneration
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: proximal tubular degeneration
- renal
- cardiovascular
PubMed 28216264increased urinary sodium excretion
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: increased urinary sodium excretion
- renal
- cardiovascular
PubMed 28216264juxtaglomerular cell hyperplasia
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: juxtaglomerular cell hyperplasia
- renal
- cardiovascular
PubMed 28216264hepatocytic vacuolar degeneration
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: hepatocytic vacuolar degeneration
- renal
- cardiovascular
PubMed 28216264decreased bone marrow erythropoiesis
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: decreased bone marrow erythropoiesis
- renal
- cardiovascular
PubMed 28216264
Related records
Trials (696)
- (mo)BETTA Trial in Transwomen for Optimization of ART
- A Clinical Study to Evaluate Renal Hemodynamic Responses to Aliskiren in Patients With Type 2 Diabetes Mellitus
- A Clinical Trial of Breast Cancer Neo-adjuvant Therapy Based on Molecular Pathway in FUSCC
- A Clinical Trial to Evaluate Pharmacokinetics of Daewon DW-ES(A) 625mg/5ml, Daewon DW-ES(B) 625mg/5ml and Megace 800mg/20ml in Healthy Male Volunteers Under Fed Condition
- A Clinical Trial to Evaluate the Safety and Efficacy of Enjuvia 0.3 mg for the Treatment of Vulvovaginal Atrophy
- A Comparative Bioavailability Study of Lisinopril Tablets, 40 mg - Effect of Food Study
- A Drug-Drug Interaction Study Between Sotagliflozin and Ramipril
- A First Time in Human Study Exploring Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of GSK2618960 in Healthy Volunteers and Patients With Relapsing Remitting Multiple Sclerosis (RRMS)
- A Fixed Dose Combination Amlodipine + Enalapril Bioavailability Study
- A Non Interventional Study To Asses The Safety, Effectiveness And Tolerability Of Quinapril (Acupil®) In An Indian Population
- A Pharmacodynamic Study to Evaluate the Effect of a Fixed Dose Combination Pill on Blood Pressure
- A Pharmacodynamic Study to Evaluate the Effect of a Fixed Dose Combination Pill on Low Density Lipoprotein (LDL) Cholesterol
- A Pharmacodynamic/Pharmacokinetic Study of Aleglitazar in Patients With Type 2 Diabetes Mellitus on Treatment With Lisinopril
- A Phase I Study to Assess the Pharmacokinetics of GSK2798745 Tablets
- A Pilot Study of Plasma Renin Activity Guided vs Generic Combination Therapy for Hypertension
- A Pilot Study: Preventing Adverse Remodelling Following Pacemaker Implantation
- A Proof-of-concept Clinical Trial Assessing the Safety of the Coordinated Undermining of Survival Paths by 9 Repurposed Drugs Combined With Metronomic Temozolomide (CUSP9v3 Treatment Protocol) for Recurrent Glioblastoma
- A Randomized, Double-blind Controlled Study Comparing LCZ696 to Medical Therapy for Comorbidities in HFpEF Patients
- A Relative Bioavailability Study of Moexipril HCl 15 mg Tablets Under Fasting Conditions
- A Relative Bioavailability Study of Ramipril 10 mg Capsules Administered Orally as a Sprinkle on Applesauce
Drugs (26)
- Benazepril Angiotensin-converting enzyme inhibitor
- Benazepril hydrochloride Angiotensin-converting enzyme inhibitor
- Captopril Angiotensin-converting enzyme inhibitor
- Cilazapril Angiotensin-converting enzyme inhibitor
- Delapril Angiotensin-converting enzyme inhibitor
- Enalapril Angiotensin-converting enzyme inhibitor
- Enalapril maleate Angiotensin-converting enzyme inhibitor
- Enalaprilat Angiotensin-converting enzyme inhibitor
- Enalaprilat anhydrous Angiotensin-converting enzyme inhibitor
- Fosinopril Angiotensin-converting enzyme inhibitor
- Fosinopril sodium Angiotensin-converting enzyme inhibitor
- Ilepatril Angiotensin-converting enzyme inhibitor
- Imidapril Angiotensin-converting enzyme inhibitor
- Lisinopril Angiotensin-converting enzyme inhibitor
- Lisinopril anhydrous Angiotensin-converting enzyme inhibitor
- Moexipril Angiotensin-converting enzyme inhibitor
- Moexipril hydrochloride Angiotensin-converting enzyme inhibitor
- Perindopril Angiotensin-converting enzyme inhibitor
- Perindopril arginine Angiotensin-converting enzyme inhibitor
- Perindopril erbumine Angiotensin-converting enzyme inhibitor