> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/abl1-5115ea4c-a149-582e-afd2-4b14718d3df2
> Record changed: 2026-10-13

# ABL1

ENSG00000097007

Target class

Kinase

Chromosome

9

Approved drugs

11

Clinical candidates (approved and in development)

24

## Clinical evidence

**Approved drugs**

11

**Clinical candidates (approved and in development)**

24

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

ABL1

**Gene name**

ABL proto-oncogene 1, non-receptor tyrosine kinase

**Gene symbol**

ABL1

**Previous gene symbols**

- ABL

**Protein name**

Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)

### Other names (3)

- JTK7
- c-ABL
- p150

## Classification

**Gene biotype**

Protein coding

**Gene family**

SH2 domain containing|Abl family tyrosine kinases

**Target class**

Kinase

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

166.08

**Tissue specificity (Gini)**

0.403

**Tissue specificity (tau)**

0.671

## Pathways and interactions

**KEGG gene identifiers**

- hsa:25

**Protein interaction confidence**

0.850015

**Protein interaction partners**

132

### Reactome pathways (13)

- R-HSA-2029482
- R-HSA-428890
- R-HSA-525793
- R-HSA-5663213
- R-HSA-5685938
- R-HSA-5693565
- R-HSA-69231
- R-HSA-8939236
- R-HSA-8940973
- R-HSA-9664422
- R-HSA-983231
- R-HSA-9841922
- R-HSA-9860927

## Genomic location

**End position**

130887675

**Start position**

130713043

**Chromosome**

9

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000097007

**HGNC ID**

HGNC:76

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:76)

**NCBI Gene ID**

25

**UniProt ID**

P00519

## Cellular location

- Cytoplasm, cytoskeleton. Nucleus. Mitochondrion . Note=Shuttles between the nucleus and cytoplasm depending on environmental signals. Sequestered into the cytoplasm through interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative stress (By similarity). .
- SUBCELLULAR LOCATION: \[Isoform IB\]: Nucleus membrane
- Lipid-anchor. Note=The myristoylated c-ABL protein is reported to be nuclear.
- Nuclear bodies
- Nucleoplasm

## Tissue expression

**Tissue specificity (tau)**

0.671492

**Expression inequality (Gini)**

0.402965

### Highest expression

Expression in transcripts per million

**Colon - Sigmoid**

166.08

**Uterus**

138.15

**Cervix - Endocervix**

135.02

**Cervix - Ectocervix**

127.5

**Esophagus - Gastroesophageal Junction**

126.28

### All tissues (54)

Expression in transcripts per million

- Colon - Sigmoid166.08
- Uterus138.15
- Cervix - Endocervix135.02
- Cervix - Ectocervix127.5
- Esophagus - Gastroesophageal Junction126.28
- Fallopian Tube124.41
- Bladder120.83
- Esophagus - Muscularis119.66
- Artery - Tibial113.06
- Ovary105.05
- Thyroid92.79
- Cells - Cultured fibroblasts91.41
- Artery - Aorta88.34
- Adipose - Subcutaneous77.4
- Colon - Transverse76.63
- Artery - Coronary76.29
- Nerve - Tibial74.09
- Breast - Mammary Tissue73.25
- Adipose - Visceral (Omentum)72.75
- Vagina71.34
- Prostate70.22
- Lung59.17
- Pituitary56.83
- Small Intestine - Terminal Ileum53.95
- Skin - Sun Exposed (Lower leg)51.28

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (41)

- GO:0000278  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000278)
- GO:0006298  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006298)
- GO:0006355  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006355)
- GO:0006974  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006974)
- GO:0006979  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006979)
- GO:0007204  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007204)
- GO:0007229  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007229)
- GO:0008630  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008630)
- GO:0010506  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010506)
- GO:0010595  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010595)
- GO:0030100  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030100)
- GO:0030155  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030155)
- GO:0030516  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030516)
- GO:0030845  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030845)
- GO:0031113  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031113)
- GO:0032489  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032489)
- GO:0032956  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032956)
- GO:0034599  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034599)
- GO:0035556  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035556)
- GO:0035791  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035791)
- GO:0038096  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038096)
- GO:0038189  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038189)
- GO:0042770  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042770)
- GO:0043065  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043065)
- GO:0043542  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043542)

And 16 more, listed on the interactive page.

### Cellular components (10)

- GO:0005634  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)
- GO:0005654  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654)
- GO:0005730  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005730)
- GO:0005737  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)
- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)
- GO:0015629  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015629)
- GO:0016604  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016604)
- GO:0032991  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032991)
- GO:0048471  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048471)
- GO:0098794  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098794)

### Molecular functions (26)

- GO:0000287  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000287)
- GO:0000400  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000400)
- GO:0000405  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000405)
- GO:0001784  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001784)
- GO:0003713  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003713)
- GO:0003785  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003785)
- GO:0004515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004515)
- GO:0004672  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004672)
- GO:0004674  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004674)
- GO:0004713  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713)
- GO:0004715  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004715)
- GO:0005080  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005080)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0005524  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005524)
- GO:0008047  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008047)
- GO:0016301  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016301)
- GO:0019899  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899)
- GO:0019905  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019905)
- GO:0030145  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030145)
- GO:0038191  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038191)
- GO:0042169  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042169)
- GO:0043539  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043539)
- GO:0051019  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051019)
- GO:0070064  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070064)
- GO:0097100  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097100)

And 1 more, listed on the interactive page.

## On-target safety

- heart disease  
### Studies

  - preclinical: Important for the heart and vasculature based on findings in genetically modified or kinase-inhibitor-treated mice. Role of kinase in heart/vasculature: Maintains ER homeostasis. left ventricular dysfunction is seen in rodents treated with imatinib  
### Biological samples

  - cardiovascular system  
PubMed 21283106  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21283106/)

## Off-target safety

- regulation of catalytic activity  
### Studies

  - biochemical: NVS\_ENZ\_hAbl, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hAbl assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology.  
### Biological samples

  - cell-free  
Evidence source  
Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data)

## Related records

### Trials (1,641)

- "Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer"
- (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST
- \[18F\]FLT-PET as a Predictive Imaging Biomaker of Treatment Responses to Regorafenib
- \[18F\]Fluoroestradiol-PET/CT Companion Imaging Study to the FORESEE Trial
- \[18F\]Fluoroestradiol-PET/CT Imaging of Invasive Lobular Carcinoma
- \[68 Ga\]-DOTANOC PET/CT in GEP-NETs
- \[68Ga\]Ga-FAPI-46 in Staging of Head and Neck Carcinomas
- \[68Ga\]Ga-PentixaFor PET/CT in Acute Myocardial Inflammation
- 11C-methionine in Diagnostics and Management of Glioblastoma Multiforme Patients (GlioMET)
- 18F-DCFBC PET/CT in Prostate Cancer
- 18F-DCFPyL Positron Emission Tomography (PET)/Computed Tomography (CT) in Men With Prostate Cancer
- 2nd or 3rd TKI-stop After 2 Years Nilotinib Pre-treatment in CML-patients
- 5 Years of Adjuvant Imatinib in Patients With Gastrointestinal Stromal Tumor With a High Risk
- 5-Fluorouracil/Leucovorin (5FU/LV) in Combination With Regorafenib in Patients With Metastatic Colorectal Cancer
- 68Ga-NODAGA-RGD PET/ CT for Tumoral Neoangiogenesis
- 68Ga-NY104 PET/CT Guided Radiation Therapy in CcRCC.
- 68Ga-NYM096/177Lu-NYM096 in Metastatic ccRCC
- 68Ga-PSMA PET/CT in Prostate Cancer
- 68Ga-PSMA PET/CT in Prostate Cancer
- 68Ga-RM2 Compared to 68Ga-PSMA-617 PET/CT for Intermediate Risk Prostate Cancer Imaging

### Drugs (28)

- Asciminib Tyrosine-protein kinase ABL inhibitor
- Asciminib hydrochloride Bcr/Abl fusion protein inhibitor
- AT-9283 Tyrosine-protein kinase ABL inhibitor
- AZD-0424 Tyrosine-protein kinase ABL inhibitor
- AZM-475271 Tyrosine-protein kinase ABL inhibitor
- Bafetinib Tyrosine-protein kinase ABL inhibitor
- Bosutinib Tyrosine-protein kinase ABL inhibitor
- Bosutinib monohydrate Bcr/Abl fusion protein inhibitor
- Dasatinib Bcr/Abl fusion protein inhibitor
- Dasatinib anhydrous Tyrosine-protein kinase ABL inhibitor
- Flumatinib Tyrosine-protein kinase ABL inhibitor
- Imatinib Bcr/Abl fusion protein inhibitor
- [Imatinib mesylate](https://trialight.com/data/asset/imatinib-mesylate-228c51e4-aef9-4351-8581-568722f6cb78.md) Tyrosine-protein kinase ABL inhibitor
- KW-2449 Tyrosine-protein kinase ABL inhibitor
- [Nilotinib](https://trialight.com/data/asset/nilotinib-d65cd4c2-39a0-42fd-a05f-8b1e12926bb2.md) Tyrosine-protein kinase ABL inhibitor
- Nilotinib hydrochloride monohydrate Tyrosine-protein kinase ABL inhibitor
- Olverembatinib Bcr/Abl fusion protein inhibitor
- Ponatinib Bcr/Abl fusion protein inhibitor
- Ponatinib hydrochloride Bcr/Abl fusion protein inhibitor
- Radotinib Bcr/Abl fusion protein inhibitor

---

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