> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/abhd12-9d7f9d77-1a57-5845-a781-277d262a6936
> Record changed: 2026-11-04

# ABHD12

ENSG00000100997

Target class

Enzyme

Chromosome

20

## Clinical evidence

**ClinGen gene-disease validity**

Definitive

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

ABHD12

**Gene name**

Abhydrolase domain containing 12, lysophospholipase

**Gene symbol**

ABHD12

**Previous gene symbols**

- C20orf22

**Protein name**

Lysophosphatidylserine lipase ABHD12 (EC 3.1.-.-) (2-arachidonoylglycerol hydrolase ABHD12) (Abhydrolase domain-containing protein 12) (hABHD12) (Monoacylglycerol lipase ABHD12) (EC 3.1.1.23) (Oxidized phosphatidylserine lipase ABHD12) (EC 3.1.-.-)

### Other names (4)

- DKFZP434P106
- dJ965G21.2
- BEM46L2
- ABHD12A

## Classification

**Gene biotype**

Protein coding

**Gene family**

Abhydrolase domain containing|2-arachidonoylglycerol hydrolases

**Target class**

Enzyme

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Highest tissue expression**

109.89

**Tissue specificity (Gini)**

0.273

**Tissue specificity (tau)**

0.62

## Pathways and interactions

**KEGG gene identifiers**

- hsa:26090

**Reactome pathways**

- R-HSA-426048

**Protein interaction confidence**

0.821

**Protein interaction partners**

8

## Genomic location

**End position**

25390866

**Start position**

25294742

**Chromosome**

20

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000100997

**HGNC ID**

HGNC:15868

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:15868)

**NCBI Gene ID**

26090

**UniProt ID**

Q8N2K0

## Cellular location

- Endoplasmic reticulum membrane
- Single-pass membrane protein .

### Publication evidence

- PubMed 30237167  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30237167/)

## Tissue expression

**Tissue specificity (tau)**

0.620401

**Expression inequality (Gini)**

0.272939

### Highest expression

Expression in transcripts per million

**Thyroid**

109.89

**Brain - Spinal cord (cervical c-1)**

105.87

**Nerve - Tibial**

92.88

**Brain - Frontal Cortex (BA9)**

82.39

**Brain - Cerebellar Hemisphere**

78.43

### All tissues (54)

Expression in transcripts per million

- Thyroid109.89
- Brain - Spinal cord (cervical c-1)105.87
- Nerve - Tibial92.88
- Brain - Frontal Cortex (BA9)82.39
- Brain - Cerebellar Hemisphere78.43
- Brain - Cerebellum75.41
- Brain - Cortex74.73
- Brain - Nucleus accumbens (basal ganglia)65.89
- Brain - Hippocampus62.78
- Brain - Anterior cingulate cortex (BA24)60.09
- Brain - Caudate (basal ganglia)57.75
- Brain - Hypothalamus56.65
- Brain - Substantia nigra54.51
- Skin - Sun Exposed (Lower leg)52.25
- Brain - Putamen (basal ganglia)51.78
- Pituitary50.66
- Skin - Not Sun Exposed (Suprapubic)46.84
- Cells - Cultured fibroblasts45.09
- Cervix - Ectocervix43.38
- Brain - Amygdala42.52
- Prostate41.47
- Vagina40.18
- Esophagus - Mucosa39.9
- Ovary39.4
- Lung38.53

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (6)

- GO:0006660  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006660)
- GO:0009395  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009395)
- GO:0019369  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019369)
- GO:0046464  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046464)
- GO:0046475  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046475)
- GO:0052651  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0052651)

### Cellular components (2)

- GO:0005789  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)

### Molecular functions (4)

- GO:0004620  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004620)
- GO:0004622  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004622)
- GO:0047372  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0047372)
- GO:0120560  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0120560)

## Related records

### Trials (58)

- A Low-Carbohydrate, Ketogenic Diet Versus Orlistat for Weight Loss
- A Pilot Study of the Efficacy of Alli in the Management of Pre-operative Weight Loss Required for Bariatric Surgery.
- A Research Study Comparing Wegovy to Other Weight Management Drugs in People Living With Obesity in America
- A Study of Xenical (Orlistat) in Overweight and Obese Adolescents
- A Study to Assess the Pharmacologic Equivalence of Two Orlistat Dosage Forms
- A Trial With EMP16 in Preparation for Late Phase Studies
- Adding Guided Self-Help Group Therapy to the Alli Weight Loss Program in Treating Binge Eating Disorder
- Aggressive Treatment of Metabolic Syndrome in Patients Receiving Clozapine for Schizophrenia
- An RCT of Metformin Vs Orlistat in Obese Anovulatory Women
- Anti-obesity Effects of Dandelion (Taraxacum Officinale L.)
- Assess the Additional Weight Loss Effect of Orlistat Used in Combination With Sibutramine
- Combinatorial Therapy for Peristent Type 2 Diabetes After Gastric Banding
- Comparison of MAG and Fish Oil Efficacy
- Double-Blind, Multi-Center, Randomized Study to Assess the Efficacy and Safety of Velneperit (S-2367) and Orlistat Administered Individually or Combined With a Reduced Calorie Diet (RCD) in Obese Subjects
- Drug Therapy Induced Weight Loss to Improve Blood Vessel Function in Subjects With Obesity
- Effect of Orlistat in Body Composition
- Effect of Orlistat on Metabolic and Hormonal Features in Women With Polycystic Ovary Syndrome (PCOS): a Randomized Controlled Clinical Trial
- Effectiveness of Brief Counseling for Weight Management
- Efficacy and Safety of ATL-962 in Obese Diabetics
- Efficacy and Safety of Liraglutide in the Treatment of Obesity Combined With Metabolism Associated Fatty Liver Disease

### Drugs (1)

- [Orlistat](https://trialight.com/data/asset/orlistat-efe96c73-de97-4970-9f8d-0c5633a8b660.md)

---

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