> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/abcc9-ac567154-33c9-56aa-94c3-07f3dbe15281
> Record changed: 2026-11-04

# ABCC9

ENSG00000069431

Target class

Transporter

Chromosome

12

Approved drugs

2

Clinical candidates (approved and in development)

4

## Clinical evidence

**Approved drugs**

2

**ClinGen gene-disease validity**

Definitive

**Clinical candidates (approved and in development)**

4

## Druggability

**Chemical probe available**

No

## Names

**Target name**

ABCC9

**Gene name**

ATP binding cassette subfamily C member 9

**Gene symbol**

ABCC9

**Protein name**

ATP-binding cassette sub-family C member 9 (Sulfonylurea receptor 2)

### Other names (2)

- SUR2
- CMD1O

## Classification

**Gene biotype**

Protein coding

**Gene family**

ATP binding cassette subfamily C

**Target class**

Transporter

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

49

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

21.82

**Tissue specificity (Gini)**

0.492

**Tissue specificity (tau)**

0.74

## Pathways and interactions

**KEGG gene identifiers**

- hsa:10060

**Protein interaction confidence**

0.797545

**Protein interaction partners**

11

### Reactome pathways (4)

- R-HSA-1296025
- R-HSA-382556
- R-HSA-5578775
- R-HSA-5678420

## Genomic location

**End position**

21942543

**Start position**

21797389

**Chromosome**

12

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000069431

**HGNC ID**

HGNC:60

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:60)

**NCBI Gene ID**

10060

**UniProt ID**

O60706

## Cellular location

- Membrane
- Multi-pass membrane protein .
- Nucleoplasm
- Plasma membrane

## Tissue expression

**Tissue specificity (tau)**

0.740103

**Expression inequality (Gini)**

0.491597

### Highest expression

Expression in transcripts per million

**Uterus**

21.82

**Fallopian Tube**

18.29

**Adipose - Subcutaneous**

16.97

**Cells - Cultured fibroblasts**

16.55

**Muscle - Skeletal**

16.17

### All tissues (54)

Expression in transcripts per million

- Uterus21.82
- Fallopian Tube18.29
- Adipose - Subcutaneous16.97
- Cells - Cultured fibroblasts16.55
- Muscle - Skeletal16.17
- Esophagus - Gastroesophageal Junction15.03
- Esophagus - Muscularis13.08
- Adipose - Visceral (Omentum)12.83
- Artery - Tibial12.81
- Cervix - Endocervix11.63
- Cervix - Ectocervix11.36
- Breast - Mammary Tissue10.1
- Liver8.69
- Thyroid8.48
- Heart - Left Ventricle8.41
- Colon - Sigmoid8.26
- Nerve - Tibial7.77
- Ovary7.76
- Artery - Coronary7.71
- Heart - Atrial Appendage7.49
- Lung6.56
- Artery - Aorta5.99
- Bladder5.67
- Vagina5.21
- Prostate5.13

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (5)

- GO:0033198  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033198)
- GO:0051607  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051607)
- GO:0055085  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055085)
- GO:0061337  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061337)
- GO:0071805  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071805)

### Cellular components (2)

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0008282  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008282)

### Molecular functions (3)

- GO:0005267  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005267)
- GO:0042626  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042626)
- GO:0044325  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044325)

## On-target safety

- abnormal pulse  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: abnormal pulse  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased/decreased blood glucose  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased/decreased blood glucose  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased urinary sodium excretion  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased urinary sodium excretion  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased blood pressure  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased blood pressure  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased heart rate  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased heart rate  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased blood glucose  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased blood glucose  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- cardiac lesions  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: cardiac lesions  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased heart rate  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased heart rate  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- cardiac arrhythmia  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: cardiac arrhythmia  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- atrioventricular block  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: atrioventricular block  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased blood insulin  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased blood insulin  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased convulsions  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased convulsions  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased blood insulin  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased blood insulin  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased urine excretion  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased urine excretion  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)

## Related records

### Trials (503)

- 24-Hour Glycemia: Rosiglitazone Versus Glimepiride In Type 2 Diabetes
- A 52-week International, Multicenter Trial With a Long -Term Extension to Evaluate Saxagliptin With Dapagliflozin in Combination With Metformin Compared to Glimepiride in Combination With Metformin in Type 2 Diabetes Who Have Inadequate Glycemic Control on Metformin Alone
- A Bioequivalence Study of Glibenclamide From Glibesyn 5 mg Tablets (Medochemie LTD Cyprus) and Daonil 5 mg Tablets (Sanofi-Aventis Cyprus Ltd. )
- A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone
- A Clinical Observation of 1565nm Non-ablative Fractional Laser in the Treatment of Androgenic Alopecia
- A Comparative Effectiveness Study of Major Glycemia-lowering Medications for Treatment of Type 2 Diabetes
- A Comparison Between Two Oral Hypoglycemics - Metformin and Glybenclamide for the Treatment of Gestational Diabetes Mellitus
- A Comparison of Atorvastatin and Glimepiride Fixed Dose Combination and Atorvastatin and Glimepiride Loose Combination in the Treatment of Patients With Type 2 Diabetes Mellitus
- A Comparison of Two Treatment Strategies in Older Participants With Type 2 Diabetes Mellitus (T2DM)
- A Double-Blind, Randomized, Parallel, Comparative Study to Evaluate the Efficacy and Safety of an Antidiabetic Agent Repaglinide for the Treatment of Type 2 Diabetes Mellitus Patients
- A Drug Drug Interaction Study to Evaluate the Effect of VCT220 on the Pharmacokinetics of Repaglinide, Rosuvastatin, and Digoxin in Healthy, Overweight, and Obese Subjects
- A Drug Interaction Study of LY3871801 in Healthy Participants
- A Drug-Drug Interaction (DDI) Study of HDM1002 With Repaglinide, Atorvastatin, Digoxin and Rosuvastatin in Healthy Subjects and Overweight Subjects.
- A Drug-Drug Interaction Study Evaluating the Perpetrator Potential of DC-806 on Cocktails of CYP450 Enzyme and Transporter Substrates in Healthy Participants
- A Drug-drug Interaction Study Evaluating the Perpetrator Potential of LY4100511 (DC-853) on Midazolam, Repaglinide, Digoxin, Rosuvastatin in Healthy Participants
- A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib
- A Drug-Drug Interaction Study of GK Activator (2) and Glyburide in Patients With Type 2 Diabetes.
- A Drug-Drug Interaction Study to Evaluate the Effect of Ripretinib on the Pharmacokinetics of a CYP2C8 Probe Substrate in Patients with Advanced GIST
- A Drug-drug Interaction Study to Evaluate the Effects of Pelabresib on the Pharmacokinetics of Repaglinide, Midazolam, and Combined Oral Contraceptive in Patients With Advanced Malignancies
- A Feasibility Study Looking at the Use of Glibenclamide and metfoRmin Versus stAndard Care in gEstational diabeteS

### Drugs (11)

- Glibornuride
- Gliclazide
- Glimepiride
- Glyburide
- Minoxidil Sulfonylurea receptor 2, Kir6.2 opener
- Naminidil Sulfonylurea receptors; K-ATP channels opener
- Nateglinide
- Pinacidil Sulfonylurea receptor 2, Kir6.2 opener
- Pinacidil anhydrous Sulfonylurea receptor 2, Kir6.2 opener
- [Repaglinide](https://trialight.com/data/asset/repaglinide-079ab94a-0782-4b94-b6e7-73df134ff710.md)
- Sarakalim Sulfonylurea receptors; K-ATP channels opener

---

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