> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/abcc8-d5b12ce5-01cf-50d6-9a80-43fb995d8808
> Record changed: 2026-10-13

# ABCC8

ENSG00000006071

Target class

Transporter

Chromosome

11

Approved drugs

10

Clinical candidates (approved and in development)

15

## Clinical evidence

**Approved drugs**

10

**ClinGen gene-disease validity**

Definitive

**Clinical candidates (approved and in development)**

15

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

ABCC8

**Gene name**

ATP binding cassette subfamily C member 8

**Gene symbol**

ABCC8

**Protein name**

ATP-binding cassette sub-family C member 8 (Sulfonylurea receptor 1)

### Other names (7)

- HI
- PHHI
- SUR1
- MRP8
- ABC36
- HHF1
- TNDM2

### Previous gene symbols (2)

- SUR
- HRINS

## Classification

**Gene biotype**

Protein coding

**Gene family**

ATP binding cassette subfamily C

**Target class**

Transporter

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

32

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

125.94

**Tissue specificity (Gini)**

0.793

**Tissue specificity (tau)**

0.942

## Pathways and interactions

**KEGG gene identifiers**

- hsa:6833

**Protein interaction confidence**

0.855273

**Protein interaction partners**

22

### Reactome pathways (3)

- R-HSA-1296025
- R-HSA-422356
- R-HSA-5683177

## Genomic location

**End position**

17476894

**Start position**

17392498

**Chromosome**

11

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000006071

**HGNC ID**

HGNC:59

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:59)

**NCBI Gene ID**

6833

**UniProt ID**

Q09428

## Cellular location

- Cell membrane
- Multi-pass membrane protein .
- Cytosol
- Golgi apparatus
- Nucleoli
- Principal piece

### Publication evidence (3)

- PubMed 24814349  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24814349/)
- PubMed 29286281  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/29286281/)
- PubMed 34815345  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/34815345/)

## Tissue expression

**Tissue specificity (tau)**

0.941915

**Expression inequality (Gini)**

0.793421

### Highest expression

Expression in transcripts per million

**Brain - Cerebellum**

125.94

**Brain - Cerebellar Hemisphere**

106.12

**Pituitary**

74.06

**Brain - Cortex**

30.02

**Brain - Frontal Cortex (BA9)**

22.18

### All tissues (54)

Expression in transcripts per million

- Brain - Cerebellum125.94
- Brain - Cerebellar Hemisphere106.12
- Pituitary74.06
- Brain - Cortex30.02
- Brain - Frontal Cortex (BA9)22.18
- Brain - Anterior cingulate cortex (BA24)14.55
- Brain - Nucleus accumbens (basal ganglia)10.19
- Brain - Hypothalamus10.12
- Pancreas10.09
- Brain - Caudate (basal ganglia)9.76
- Brain - Spinal cord (cervical c-1)9.75
- Cervix - Ectocervix8.82
- Brain - Hippocampus8.25
- Thyroid7.08
- Brain - Amygdala6.94
- Brain - Putamen (basal ganglia)6.89
- Stomach6.49
- Lung5.59
- Brain - Substantia nigra5.38
- Nerve - Tibial5.19
- Cervix - Endocervix4.32
- Prostate3.43
- Uterus2.26
- Vagina2.05
- Fallopian Tube1.7

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (2)

- GO:0006813  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006813)
- GO:0050796  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050796)

### Cellular components (2)

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0008282  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008282)

### Molecular functions (5)

- GO:0005267  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005267)
- GO:0005524  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005524)
- GO:0015272  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015272)
- GO:0019829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019829)
- GO:0044325  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044325)

## On-target safety

- abnormal pulse  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: abnormal pulse  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased/decreased blood glucose  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased/decreased blood glucose  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased urinary sodium excretion  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased urinary sodium excretion  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased blood pressure  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased blood pressure  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased heart rate  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased heart rate  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased blood glucose  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased blood glucose  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- cardiac lesions  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: cardiac lesions  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased heart rate  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased heart rate  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- cardiac arrhythmia  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: cardiac arrhythmia  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased convulsions  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased convulsions  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- atrioventricular block  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: atrioventricular block  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased blood insulin  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased blood insulin  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased blood insulin  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased blood insulin  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased urine excretion  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased urine excretion  
### Biological samples (3)

  - pancreas
  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)

## Related records

### Trials (698)

- 24-Hour Glycemia: Rosiglitazone Versus Glimepiride In Type 2 Diabetes
- 3-year Study in Dry Eye Disease Patients With Severe Keratitis Receiving Ikervis® (1mg/mL Ciclosporin)
- A 52-week International, Multicenter Trial With a Long -Term Extension to Evaluate Saxagliptin With Dapagliflozin in Combination With Metformin Compared to Glimepiride in Combination With Metformin in Type 2 Diabetes Who Have Inadequate Glycemic Control on Metformin Alone
- A Bioequivalence Study of Glibenclamide From Glibesyn 5 mg Tablets (Medochemie LTD Cyprus) and Daonil 5 mg Tablets (Sanofi-Aventis Cyprus Ltd. )
- A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone
- A Comparative Effectiveness Study of Major Glycemia-lowering Medications for Treatment of Type 2 Diabetes
- A Comparison Between Two Oral Hypoglycemics - Metformin and Glybenclamide for the Treatment of Gestational Diabetes Mellitus
- A Comparison of Atorvastatin and Glimepiride Fixed Dose Combination and Atorvastatin and Glimepiride Loose Combination in the Treatment of Patients With Type 2 Diabetes Mellitus
- A Comparison of Two Treatment Strategies in Older Participants With Type 2 Diabetes Mellitus (T2DM)
- A Double-Blind, Randomized, Parallel, Comparative Study to Evaluate the Efficacy and Safety of an Antidiabetic Agent Repaglinide for the Treatment of Type 2 Diabetes Mellitus Patients
- A Drug Drug Interaction Study to Evaluate the Effect of VCT220 on the Pharmacokinetics of Repaglinide, Rosuvastatin, and Digoxin in Healthy, Overweight, and Obese Subjects
- A Drug Interaction Study of LY3871801 in Healthy Participants
- A Drug Interaction Study of Tasisulam in Patients With Advanced Cancer or Lymphoma
- A Drug-Drug Interaction (DDI) Study of HDM1002 With Repaglinide, Atorvastatin, Digoxin and Rosuvastatin in Healthy Subjects and Overweight Subjects.
- A Drug-Drug Interaction Study Evaluating the Perpetrator Potential of DC-806 on Cocktails of CYP450 Enzyme and Transporter Substrates in Healthy Participants
- A Drug-drug Interaction Study Evaluating the Perpetrator Potential of LY4100511 (DC-853) on Midazolam, Repaglinide, Digoxin, Rosuvastatin in Healthy Participants
- A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib
- A Drug-Drug Interaction Study of GK Activator (2) and Glyburide in Patients With Type 2 Diabetes.
- A Drug-Drug Interaction Study to Evaluate the Effect of Ripretinib on the Pharmacokinetics of a CYP2C8 Probe Substrate in Patients with Advanced GIST
- A Drug-drug Interaction Study to Evaluate the Effects of Pelabresib on the Pharmacokinetics of Repaglinide, Midazolam, and Combined Oral Contraceptive in Patients With Advanced Malignancies

### Drugs (15)

- Acetohexamide Sulfonylurea receptor 1, Kir6.2 blocker
- Chlorpropamide Sulfonylurea receptor 1, Kir6.2 blocker
- Gliclazide Sulfonylurea receptor 1, Kir6.2 blocker
- [Glimepiride](https://trialight.com/data/asset/glimepiride-9fa39756-be21-4a6d-999a-bc4b8645f5c9.md) Sulfonylurea receptor 1, Kir6.2 blocker
- Glipizide Sulfonylurea receptor 1, Kir6.2 blocker
- Glyburide Sulfonylurea receptor 1, Kir6.2 blocker
- Mitiglinide Sulfonylurea receptor 1, Kir6.2 blocker
- Mitiglinide calcium dihydrate Sulfonylurea receptor 1, Kir6.2 blocker
- Naminidil Sulfonylurea receptors; K-ATP channels opener
- Nateglinide Sulfonylurea receptor 1, Kir6.2 blocker
- [Repaglinide](https://trialight.com/data/asset/repaglinide-079ab94a-0782-4b94-b6e7-73df134ff710.md) Sulfonylurea receptor 1, Kir6.2 blocker
- Sarakalim Sulfonylurea receptors; K-ATP channels opener
- Tolazamide Sulfonylurea receptor 1, Kir6.2 blocker
- Tolbutamide Sulfonylurea receptor 1, Kir6.2 blocker
- Tolbutamide sodium Sulfonylurea receptor 1, Kir6.2 blocker

---

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