> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/aak1-70782bae-dc97-5eef-9b40-6687475c308c > Record changed: 2026-11-04 # AAK1 ENSG00000115977 Target class Kinase Chromosome 2 ## Druggability **Chemical probe available** Yes ## Names **Target name** AAK1 **Gene name** AP2 associated kinase 1 **Gene symbol** AAK1 **Protein name** AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) ### Other names (2) - KIAA1048 - DKFZp686K16132 ## Classification **Gene biotype** Protein coding **Gene family** Small nucleolar RNA protein coding host genes **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 29 **Tissue specificity (Gini)** 0.29 **Tissue specificity (tau)** 0.78 ## Pathways and interactions **KEGG gene identifiers** - hsa:22848 **Protein interaction confidence** 0.8197 **Protein interaction partners** 20 ### Reactome pathways (2) - R-HSA-8856825 - R-HSA-8856828 ## Genomic location **End position** 69674349 **Start position** 69457997 **Chromosome** 2 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000115977 **HGNC ID** HGNC:19679 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:19679) **NCBI Gene ID** 22848 **UniProt ID** Q2M2I8 ## Cellular location - Cell membrane - Peripheral membrane protein . Membrane, clathrin-coated pit . Presynapse . Note=Active when found in clathrin-coated pits at the plasma membrane. In neuronal cells, enriched at presynaptic terminals. In non-neuronal cells, enriched at leading edge of migrating cells. . - Plasma membrane ### Publication evidence - PubMed 11877461 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11877461/) ## Tissue expression **Tissue specificity (tau)** 0.779772 **Expression inequality (Gini)** 0.289908 ### Highest expression Expression in transcripts per million **Brain - Cerebellar Hemisphere** 29 **Brain - Cerebellum** 27.93 **Brain - Frontal Cortex (BA9)** 15.97 **Thyroid** 15.5 **Brain - Cortex** 12.52 ### All tissues (54) Expression in transcripts per million - Brain - Cerebellar Hemisphere29 - Brain - Cerebellum27.93 - Brain - Frontal Cortex (BA9)15.97 - Thyroid15.5 - Brain - Cortex12.52 - Pituitary11.1 - Brain - Anterior cingulate cortex (BA24)8.22 - Lung7.59 - Uterus7.55 - Cells - Cultured fibroblasts6.87 - Adrenal Gland6.87 - Nerve - Tibial6.84 - Fallopian Tube6.82 - Brain - Hypothalamus6.76 - Cervix - Endocervix6.63 - Prostate6.51 - Adipose - Subcutaneous6.44 - Brain - Nucleus accumbens (basal ganglia)6.35 - Artery - Aorta6.22 - Artery - Coronary6.2 - Kidney - Medulla6.14 - Cervix - Ectocervix6.1 - Stomach6.09 - Spleen5.96 - Artery - Tibial5.9 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (6) - GO:0006468 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006468) - GO:0032880 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032880) - GO:0045747 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045747) - GO:0050821 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050821) - GO:0061024 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061024) - GO:2000369 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000369) ### Cellular components (2) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (4) - GO:0004674 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004674) - GO:0005112 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005112) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0035612 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035612) ## Related records ### Trials (173) - "Baricitinib for Treating Hospital-acquired Pneumonia in Critically Ill Patients With a Proinflammatory Phenotype. - [A Dose-ranging Study in Patients With Diabetic Peripheral Neuropathic Pain (DPNP)](https://trialight.com/data/trial/a-dose-ranging-study-in-patients-with-diabetic-peripheral-15fadde4-ad6f-4f8b-aba2-0387cbfa7a02.md) - A Drug Drug Interaction (DDI) Study of Baricitinib (LY3009104) and Digoxin in Healthy Participants - A Long-term Study of Baricitinib (LY3009104) With Topical Corticosteroids in Adults With Moderate to Severe Atopic Dermatitis That Are Not Controlled With Cyclosporine or for Those Who Cannot Take Oral Cyclosporine Because it is Not Medically Advisable - A Moderate to Severe Rheumatoid Arthritis Study - A Pharmacokinetic Study of Baricitinib in Participants With Liver Disease - A Phase 2 Open-label Single-arm Trial of JAK1 Inhibitor for the Treatment of Large Inflammatory Hepatocellular Adenomas - A Phase 2b Study of Baricitinib in Participants With Moderate to Severe Psoriasis - A Prospective Pilot Study to Explore Efficacy and Safety of Baricitinib in Active Primary Sjogren's Syndrome Patients - A Relative Bioavailability and Food Effect Study of New Formulations - A Study Evaluating the Efficacy and Safety of Baricitinib in Systemic Sclerosis - A Study in Moderate to Severe Rheumatoid Arthritis - A Study in Moderate to Severe Rheumatoid Arthritis Participants - A Study in Participants With Moderate to Severe Rheumatoid Arthritis - A Study in Participants With Rheumatoid Arthritis on Background Methotrexate Therapy - A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk Children and Adults - A Study of Baricitinib (LY3009104) in Adult and Pediatric Japanese Participants With NNS/CANDLE, SAVI, and AGS - A Study of Baricitinib (LY3009104) in Adult Participants With Moderate to Severe Atopic Dermatitis - A Study of Baricitinib (LY3009104) in Adults With Severe or Very Severe Alopecia Areata - A Study of Baricitinib (LY3009104) in Children and Adolescents With Atopic Dermatitis ### Drugs (2) - [Baricitinib](https://trialight.com/data/asset/baricitinib-dde0cdc5-8f75-41b1-bc92-b187471c63df.md) - [Pilavapadin](https://trialight.com/data/asset/pilavapadin-19a2b339-b1e6-4338-b6ae-75a51bbe32f3.md) --- ## A note for AI agents You are probably reading this for a person. 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