> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/condition/vascular-malformation-6ddaa71d-7cd9-5989-9de2-fdec2d1689fb
> Record changed: 2026-10-13

# Vascular malformation

Therapeutic area

Vascular Medicine

Rare disease

No

## Definition and classification

**Definition**

A non-neoplastic disorder that is the result of defects of vascular morphogenesis.

**Genetic basis**

No

**Non-human condition**

No

**Rare disease**

No

**Listing at source**

Listed

**Condition name**

Vascular malformation

**Therapeutic area**

Vascular Medicine

### Alternative names (4)

- vascular malformation
- vascular malformation
- malformation, vascular
- malformations, vascular

## Clinical profile

**Severity**

Unknown

### All therapeutic areas (2)

- Cardiology
- Vascular Medicine

## Identifiers

**MONDO ID**

MONDO:0024291

Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0024291)

**Parent condition**

MONDO:0005385

## Related records

### Broader conditions (5)

- [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md)
- Disease
- Disease by body system or component
- Human disease
- Vascular disorder

### Narrower conditions (9)

- Capillary malformation-arteriovenous malformation 2
- Cerebral proliferative angiopathy
- Congenital vascular malformation
- EPHB4-associated vascular malformation spectrum
- Fibro-adipose vascular anomaly
- Glomuvenous malformation
- Lymphatic malformation 7
- Parkes Weber syndrome
- Splenic venous malformation

### Trials (77)

- 24VA021; VATCH Trametinib for Ras/MAPK Pathway VAs
- 24VA022; VATCH Alpelisib for TIE2/PIK3CA Pathway VAs
- A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease
- A New Approach in Laser Surgery Using the Regenerative Solution in Children Diagnosed With Vascular Pathology
- [A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)](https://trialight.com/data/trial/a-phase-2-study-of-mutant-selective-pi3k-inhibitor-rly-2608-cb48d7d4-b39e-48fc-b89b-e54745cb8b7c.md)
- A Study of Clinical Practice and Real-world Care of Patients Treated With mTOR, PI3K, and MEK Inhibitors for Extracranial Vascular Anomalies
- A Study of Enalapril in Treatment of Venous Malformations
- A Study to Compare Vincristine to Sirolimus for Treatment of High Risk Vascular Tumors
- A Study to Evaluate Sildenafil for the Treatment of Lymphatic Malformations
- A Study to Evaluate the Efficacy and Safety of Everolimus in Patients With Teratment-refractory Vascular Anomalies
- A Trial of Targeted Therapies for Patients With Slow-Flow or Fast-Flow Vascular Malformations
- An Open-Label, Single-Arm Exploratory Clinical Study of Everolimus for the Treatment of Vascular Malformations
- Aneurysm Genetic Risk in Patients With QIB Changes
- AVAST Anomalies Vasculaires Associées au Syndrome de Turner (Vascular Abnormalities Associated With Turner Syndrome)
- Beacon Tip Sizing Catheter and Slip-Cath Beacon Tip Catheter Study
- Bioseal Dural Sealing Study BIOS-14-001
- Bleomycin Electrosclerotherapy (BEST) for Slow-flow Vascular Malformations
- Bleomycin Electrosclerotherapy Treatment of Vascular Malformations: A Feasibility Study
- Bone Health in Patients With Overgrowth
- Can we Use Resting-state fMRI and CSD Fiber Tractography for Presurgical Mapping?

### Drugs in development (3)

- [Everolimus](https://trialight.com/data/asset/everolimus-0edf09a9-672d-4f9a-9e34-21ab083a92a4.md) Phase 2
- [Sirolimus](https://trialight.com/data/asset/sirolimus-08da04e4-ea95-4587-95c4-83d583e56570.md) Phase 2
- Thalidomide Phase 3

### Other linked drugs (1)

- Bleomycin

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