> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/uveal-melanoma-80b21ba9-9f54-5b09-afc5-b30b0b21f2b0 > Record changed: 2026-10-13 # Uveal melanoma Therapeutic area Oncology Rare disease Yes ## Definition and classification **Definition** A melanoma derived from melanocytes of the uveal tract. It is the most common primary intraocular tumor in the United States and Western Europe. Similar to melanoma of the skin, it is rare in Africa and Asia. Diagnostic procedures include ophthalmoscopic exam, fluorescein angiography and ultrasound. Treatment includes: surgical excision of the eye, iridocyclectomy and tumor resection. Recent treatments also include radiotherapy or photo coagulation. Classification of uveal melanomas recognizes four cell types within these tumors: epithelioid, intermediate, mixed cell, and spindle cell types. The spindle cell type uveal melanomas are further sub-classified as spindle cell type A and spindle cell type B. **Genetic basis** Yes **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Uveal melanoma **Therapeutic area** Oncology ### Alternative names (10) - uveal melanoma - intraocular melanoma - melanoma (disease) of uvea - melanoma of the uvea - melanoma of uvea - melanoma, uveal, malignant - uvea melanoma - uvea melanoma (disease) - uveal melanoma - iris melanoma ## Clinical profile **Disease mechanisms** - Developmental **Severity** Severe ### All therapeutic areas (3) - Neurology - Oncology - Ophthalmology ## Identifiers **MONDO ID** MONDO:0006486 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0006486) **Parent condition** MONDO:0002659 ## Related records ### Broader conditions (28) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - Disease - Disease by body system or component - Disease by developmental or physiological process - Disease by etiologic mechanism - Disorder of development or morphogenesis - Disorder of orbital region - Disorder of visual system - Eye disorder - Eye neoplasm - [Head and neck cancer](https://trialight.com/data/condition/head-and-neck-cancer-3a2645b9-a3db-5103-b6f8-5d2ec40c5339.md) - [Head and neck neoplasm](https://trialight.com/data/condition/head-and-neck-neoplasm-6436d68c-825f-5a7a-bb29-99e9ae9e009a.md) - Human disease - Melanocytic neoplasm - [Melanoma](https://trialight.com/data/condition/melanoma-457e9de6-dcd9-56fb-be48-0290fb4386ef.md) - Neoplasm - Neoplastic disease or syndrome - Nervous system cancer - Nervous system disorder ### Narrower conditions (22) - Choroid epithelioid cell melanoma - Choroid mixed cell melanoma - Choroid necrotic melanoma - Choroid spindle cell melanoma - Ciliary body epithelioid cell melanoma - Ciliary body mixed cell melanoma - Ciliary body spindle cell melanoma - Epithelioid cell uveal melanoma - Intermediate cell type choroid melanoma - Intermediate cell type ciliary body melanoma - Intermediate cell type iris melanoma - Intermediate cell type uveal melanoma - Iris melanoma - Iris spindle cell melanoma - Malignant choroid melanoma - Malignant ciliary body melanoma - Medium/large size posterior uveal melanoma - Mixed cell uveal melanoma - Necrotic uveal melanoma - Posterior uveal melanoma ### Trials (277) - (Neo)Adjuvant IDE196 (Darovasertib) in Patients With Localized Ocular Melanoma - 5 Year Registry Study to Track Clinical Application of DecisionDx-UM Assay Results and Associated Patient Outcomes - A Cohort IND Expanded Access Program for Supporting Patient Access to Tebentafusp - [A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.](https://trialight.com/data/trial/a-dose-escalation-and-dose-expansion-study-of-intratumoral-7ff04566-d63e-405b-be58-a6b39637fe93.md) - A Long-Term Follow-Up Study of Subjects Completing the AU-011-301(CoMpass) for Early Choroidal Melanoma - A Phase 1 and 2 Study of VMD-102 in Hepatocellular Carcinoma and Other Solid Tumors - A Phase 1 Study of \[225Ac\]-FPI-1434 Injection - A Phase 1-1b Study to Evaluate the Safety, Efficacy and Dosimetry of Study Drug A9-3408 in Subjects With Metastatic Melanoma - A Phase 3 Randomized, Masked, Controlled Trial to Evaluate Efficacy and Safety of Belzupacap Sarotalocan (AU-011) Treatment Compared to Sham Control in Subjects With Primary Indeterminate Lesions or Small Choroidal Melanoma - A Phase I Study of LXS196 in Patients With Metastatic Uveal Melanoma. - A Phase I/II Study of DYP688 in Patients With Metastatic Uveal Melanoma and Other GNAQ/11 Mutant Melanomas - A Phase Ib/II Study of AEB071 and MEK162 in Adult Patients With Metastatic Uveal Melanoma - A Phase II Study of BVD-523 in Metastatic Uveal Melanoma - A Phase II Study of Isolated Hepatic Perfusion (IHP) in Patients With Ocular Melanoma - A Phase II Study of Sunitinib Versus Dacarbazine in the Treatment of Patients With Metastatic Uveal Melanoma - A Prospective Natural History Study in Uveal Melanoma - A Randomised Phase II Study of Roginolisib in Patients With Advanced/Metastatic Uveal Melanoma - A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma - A Registry of Subjects With Primary Indeterminate Lesions or Choroidal Melanoma - A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies ### Drugs in development (54) - [Aflibercept](https://trialight.com/data/asset/aflibercept-6bb09e87-ca99-436b-8634-71b90510b8fb.md) Phase 2 - Aldesleukin Phase 2 - [Alpelisib](https://trialight.com/data/asset/alpelisib-0b0ae0f7-4313-42ef-bbbe-3280ed5ea15c.md) Phase 1 - [Avelumab](https://trialight.com/data/asset/avelumab-7197343d-e77c-45d7-978a-ad6cf91f6437.md) Phase 1 - Avutometinib Phase 2 - Belinostat Phase 2 - Belzupacap sarotalocan Phase 2 - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) Phase 2 - [Binimetinib](https://trialight.com/data/asset/binimetinib-f5914744-65e2-4d8c-8482-9f51a406315e.md) Phase 2 - Cabozantinib S-malate Phase 2 - CDX-1140 Phase 1 - [Cisplatin](https://trialight.com/data/asset/cisplatin-e039621a-d679-4740-88ac-94842bf4a91e.md) Phase 2 - Crizotinib Phase 2 - [Cyclophosphamide](https://trialight.com/data/asset/cyclophosphamide-25b75968-e3cd-410a-9b24-0c349d8f7663.md) Phase 2 - Dacarbazine Phase 3 - Darovasertib Phase 1 - Defactinib hydrochloride Phase 2 - Entinostat Phase 2 - Entrectinib Phase 1 - Epacadostat Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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