> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/undifferentiated-pleomorphic-sarcoma-8ce503dc-2130-5bc0-8cb5-cd8dfa2b9ef6 > Record changed: 2026-10-13 # Undifferentiated pleomorphic sarcoma Therapeutic area Oncology Rare disease Yes ## Definition and classification **Definition** An undifferentiated soft tissue sarcoma characterized by the presence of a pleomorphic malignant cellular infiltrate. It is also known as malignant fibrous histiocytoma. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Undifferentiated pleomorphic sarcoma **Therapeutic area** Oncology ### Alternative names (27) - undifferentiated pleomorphic sarcoma - MFH - Storiform-pleomorphic MFH - Storiform-pleomorphic fibrous histiocytoma - Storiform-pleomorphic malignant fibrous histiocytoma - UPS - Unclassified Pleomorphic sarcoma (formerly "MFH") - Unclassified Pleomorphic sarcoma (formerly "malignant fibrous histiocytoma") - adult malignant fibrous histiocytoma - adult unclassified pleomorphic sarcoma - adult undifferentiated pleomorphic sarcoma - fibrous histiocytoma, malignant - fibrous histiocytoma, malignant (morphologic abnormality) - fibroxanthosarcoma - fibroxanthosarcoma (morphologic abnormality) - histiocytoma, fibrous, malignant - malignant fibrous cytoma - malignant fibrous histiocytoma - malignant fibrous histiocytoma of soft tissue and bone - malignant fibrous histiocytoma of the soft tissue and bone - malignant fibroxanthoma - unclassified pleomorphic sarcoma - undifferentiated pleomorphic sarcoma - undifferentiated pleomorphic soft tissue sarcoma - malignant fibrohistiocytic tumors And 2 more, listed on the interactive page. ## Clinical profile **Severity** Severe ### All therapeutic areas (2) - Oncology - Rheumatology ## Identifiers **MONDO ID** MONDO:0002142 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0002142) **Parent condition** MONDO:0005509 ## Related records ### Broader conditions (23) - Bone cancer - [Bone disorder](https://trialight.com/data/condition/bone-disorder-83c4c003-c8df-50f7-8829-fbbb5d5adf76.md) - Bone neoplasm - Bone sarcoma - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - Connective and soft tissue neoplasm - [Connective tissue disorder](https://trialight.com/data/condition/connective-tissue-disorder-3df54ecd-c080-5b4c-b60d-fab4846ea17b.md) - Connective tissue neoplasm - Disease - Disease by body system or component - Disease by etiologic mechanism - Histiocytoma - Human disease - Malignant soft tissue neoplasm - Musculoskeletal system cancer - Musculoskeletal system disorder - Neoplasm - Neoplastic disease or syndrome - [Sarcoma](https://trialight.com/data/condition/sarcoma-96102668-50d9-5d69-b154-719396a38dc1.md) ### Narrower conditions (3) - Cutaneous undifferentiated pleomorphic sarcoma - Malignant giant cell tumor of soft parts - Undifferentiated pleomorphic sarcoma, inflammatory variant ### Trials (90) - [A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors](https://trialight.com/data/trial/a-phase-1-first-in-human-study-of-okn4395-and-pembrolizumab-d5f0ed43-9c3d-4e12-976c-c1165c2cdf30.md) - A Phase 2 Study of 9-ING-41Combined With Chemotherapy in Adolescents and Adults With Advanced Sarcomas - A Phase II Study of Eribulin and Pembrolizumab in Soft Tissue Sarcomas - A Study of Bevacizumab in Combination With Chemotherapy for Treatment of Osteosarcoma - A Study of Doxorubicin Plus Olaratumab (LY3012207) in Participants With Advanced or Metastatic Soft Tissue Sarcoma - A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Soft Tissue Sarcoma - A Study of LY3435151 in Participants With Solid Tumors - A Study of Pembrolizumab Plus Local Chemotherapy Using Isolated Limb Infusion (ILI) for Patients With Sarcoma in the Arm or Leg - A Study of XmAb®23104 in Subjects With Selected Advanced Solid Tumors (DUET-3) - ABBV-085, an Antibody Drug Conjugate, in Subjects With Advanced Solid Tumors - Alisertib in Treating Patients With Advanced or Metastatic Sarcoma - Autologous Dendritic Cell Vaccine in Patients With Soft Tissue Sarcoma - AZD0530 in Treating Patients With Recurrent Locally Advanced or Metastatic Soft Tissue Sarcoma - BI 2536 in Treating Patients With Recurrent or Metastatic Solid Tumors - Brightline-3: A Study to Find Out Whether Brigimadlin in Combination With Ezabenlimab Helps People With Advanced Soft Tissue Sarcoma - Brostallicin in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma - Brostallicin or Doxorubicin as First-Line Therapy in Treating Patients With Relapsed, Refractory, or Metastatic Soft Tissue Sarcoma - CAB-AXL-ADC Safety and Efficacy Study in Adult and Adolescent Patients With Sarcoma - Celecoxib and Radiation Therapy in Treating Patients With Stage II or Stage III Soft Tissue Sarcoma of the Arm, Hand, Leg, or Foot That Has Been Removed by Surgery - Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma ### Drugs in development (8) - [Catequentinib](https://trialight.com/data/asset/catequentinib-d03b78d4-b5a5-4756-bbf6-e56f5ec2b7dc.md) Phase 2 - [Ipilimumab](https://trialight.com/data/asset/ipilimumab-06c42b29-e333-4f3c-94fe-dbea5fe48cd4.md) Phase 2 - [Nivolumab](https://trialight.com/data/asset/nivolumab-d2e207ca-a7d1-43d0-987f-43ef7eef8f1b.md) Phase 2 - [Palbociclib](https://trialight.com/data/asset/palbociclib-2686787c-5f11-4b65-9a5b-549fcd2af644.md) Phase 1 - [Pembrolizumab](https://trialight.com/data/asset/pembrolizumab-f9ac1934-47a5-4a53-ae55-20b7d53d8815.md) Phase 1 - Samrotamab vedotin Phase 1 - [Sintilimab](https://trialight.com/data/asset/sintilimab-e2618eaf-967e-401c-aed4-7546875a6d3e.md) Phase 2 - [Toripalimab](https://trialight.com/data/asset/toripalimab-92e6b353-a6c4-4e1e-a99f-559038ba7177.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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