Tuberculosis
Therapeutic area
Infectious Disease
Rare disease
Yes
- Definition
- A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use.
- Genetic basis
- No
- Non-human condition
- No
- Rare disease
- Yes
- Listing at source
- Listed
- Condition name
- Tuberculosis
- Therapeutic area
- Infectious Disease
- tuberculosis
- tuberculosis disease
- active tuberculosis
- Kochs disease
- TB
- Disease mechanisms
- Acquired
- All therapeutic areas
- Infectious Disease
- Severity
- Severe
- MONDO ID
- MONDO:0018076
- Parent condition
- MONDO:0000314
Related records
Broader conditions (8)
- Bacterial infectious disease
- Disease
- Disease by etiologic mechanism
- Disease of primarily extrinsic mechanism
- Human disease
- Infectious disease
- Mycobacterial infectious disease
- Primary bacterial infectious disease
Narrower conditions (53)
- Abdominal tuberculosis
- Active tuberculosis
- Cardiac tuberculosis
- Central nervous system tuberculosis
- Cutaneous tuberculosis
- Drug-resistant tuberculosis
- Endocrine tuberculosis
- Esophageal tuberculosis
- Extensively drug-resistant tuberculosis
- Extrapulmonary tuberculosis
- Gastrointestinal tuberculosis
- Hepatic tuberculosis
- Intestinal tuberculosis
- Laryngeal tuberculosis
- Latent tuberculosis infection
- Lupus vulgaris
- Lymph node tuberculosis
- Male genital tuberculosis
- Meningeal tuberculosis
- Miliary tuberculosis
Trials (1,154)
- "Conducting A Study On Video Observed Therapy In The Management Of Tuberculosis"
- "Efficacy and Safety of Levofloxacin vs Isoniazid in Latent Tuberculosis Infection in Liver Transplant Patients".
- 1HP Versus 3HR in the Treatment of Tuberculosis Infection in Vietnam
- A 14 Day Early Bactericidal Activity Study of Nitazoxanide for the Treatment of Tuberculosis
- A 6-Month Safety, Efficacy, and Pharmacokinetic (PK) Trial of Delamanid in Pediatric Participants With Multidrug Resistant Tuberculosis (MDR-TB)
- A BCG Challenge Model Study to Assess Anti-mycobacterial Immunity Induced by BCG and a Candidate TB Vaccine, MVA85A
- A Bioavailability Study of Rifabutin and Lopinavir/Ritonavir in Healthy Adult Subjects
- A Bioequivalence Study of Two Different Dosages of Isoniazid Tablet Formulations in Human Healthy Volunteers
- A Blinded, Cross-sectional, Diagnostic Evaluation Study Performed in Pulmonary TB Suspects at the TB Dispensary for Sector 4 of the Marius-Nasta-Institute in Bucharest, Romania
- A Clinical Challenge Study of BCG in Healthy Volunteers
- A Clinical Study Investigating Rifampicin and Dolutegravir in Combination in Healthy Volunteers
- A Clinical tRial of Endobronchial Ultrasound for the Diagnosis of MEDiastinal lymphadenopathY (REMEDY)
- A Clinical Trial of the Safety, Pharmacokinetics and Hematologic Effects of Imatinib on Myelopoiesis in Adults When Given With and Without Isoniazid and Rifabutin
- A Cluster-Randomized Trial of DOTS vs DOTS Plus Active Case Finding
- A Confirmatory Trial of Adjunctive NAC to Prevent Post Tuberculosis Lung Disease
- A Controlled Human Infection Model (CHIM) With Intradermal BCG in Malawi
- A Controlled Smoking Cessation Trial and Prospective Cohort Study of Tuberculosis (TB) Treatment Outcomes
- A Controlled Trial of a 4-Month Quinolone-Containing Regimen for the Treatment of Pulmonary Tuberculosis
- A Home-Based Approach to Tuberculosis Preventive Treatment Management
- A Knowledge Translation Intervention for TB/HIV Treatment Adherence, in Zomba District, Malawi
Approved drugs (19)
- Aminosalicylic acid
- Bedaquiline
- Bedaquiline fumarate
- Capreomycin
- Capreomycin sulfate
- Cycloserine
- Delamanid
- Ethambutol
- Ethambutol hydrochloride
- Ethionamide
- Isoniazid
- Pretomanid
- Protionamide
- Pyrazinamide
- Rifabutin
- Rifampin
- Rifamycin
- Rifapentine
- Streptomycin sulfate
Drugs in development (90)
- Abacavir Phase 3
- Acetylcysteine Phase 2
- Allopurinol Phase 1
- Amikacin Phase 2
- Aminosalicylate sodium
- Amithiozone Phase 2
- Amoxicillin Phase 2
- Aspirin Phase 2
- Atorvastatin Phase 2
- Auranofin Phase 2
- Azacitidine Phase 1
- Azithromycin Phase 2
- BCG LIVE Phase 1
- BCG vaccine Phase 3
- BTZ-043 Phase 2
- Celecoxib Phase 1
- Cephalexin Phase 2
- Cholecalciferol Phase 3
- Clarithromycin Phase 3
- Clavulanate potassium Phase 2
Other linked drugs (4)
- Albendazole
- Ethylenediamine
- Lidocaine
- Prilocaine