> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/transitional-cell-carcinoma-19611feb-3997-59b1-ad3d-49b845cbe40f > Record changed: 2026-10-13 # Transitional cell carcinoma Therapeutic area Oncology Rare disease No ## Definition and classification **Definition** A malignant neoplasm arising from the transitional epithelium, usually affecting the urinary bladder, ureter, or renal pelvis. It may or may not have a papillary configuration. It is graded 1 to 3 or 4 according to the degree of cellular differentiation and architectural patterns. Grade 1 transitional cell carcinoma is histologically benign but it may recur. Transitional cell carcinomas may also affect the upper respiratory tract and the ovaries. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Transitional cell carcinoma **Therapeutic area** Oncology ### Alternative names (11) - transitional cell carcinoma - transitional cell neoplasm - transitional cell tumor - transitional cell tumour - carcinoma of transitional epithelial cell - carcinoma of urothelial cell - carcinoma, urothelial, malignant - transitional carcinoma - transitional cell carcinoma - transitional epithelial cell carcinoma - urothelial cell carcinoma ## Clinical profile **All therapeutic areas** - Oncology **Severity** Severe ## Identifiers **MONDO ID** MONDO:0006474 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0006474) **Parent condition** MONDO:0004993 ## Related records ### Broader conditions (9) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - [Carcinoma](https://trialight.com/data/condition/carcinoma-575e4c82-5fa5-5455-b1b7-30972eca1a2f.md) - Disease - Disease by etiologic mechanism - [Epithelial neoplasm](https://trialight.com/data/condition/epithelial-neoplasm-5584692a-5e9d-58e1-9432-db6264993a80.md) - Human disease - Neoplasm - Neoplastic disease or syndrome ### Narrower conditions (36) - Bartholin gland transitional cell carcinoma - Bladder carcinoma in situ - Bladder papillary urothelial carcinoma - Bladder sarcomatoid transitional cell carcinoma - Bladder transitional cell carcinoma - Bladder urachal urothelial carcinoma - Endometrial transitional cell carcinoma - Fallopian tube transitional cell carcinoma - Infiltrating bladder lymphoepithelioma-like carcinoma - Infiltrating bladder urothelial carcinoma - Infiltrating bladder urothelial carcinoma sarcomatoid variant - Infiltrating bladder urothelial carcinoma, clear cell variant - Infiltrating renal pelvis transitional cell carcinoma - Infiltrating ureter transitional cell carcinoma - Kidney pelvis sarcomatoid transitional cell carcinoma - Lipid-cell variant infiltrating bladder urothelial carcinoma - Lymphoma-like variant infiltrating bladder urothelial carcinoma - Microcystic variant infiltrating bladder urothelial carcinoma - Micropapillary variant infiltrating bladder urothelial carcinoma - Nested variant infiltrating bladder urothelial carcinoma ### Trials (612) - 18F-LN1 PET/CT in Urothelial Carcinomas - 18F-T2 PET/CT Imaging for CAIX Positive Solid Tumors - 18Fluorine-Fluciclovine PET/CT for Staging Muscle Invasive Bladder Cancer Preceding Radical Cystectomy - 2nd Line Gemcitabine Monotherapy for Transitional Cell Carcinoma of Urothelium (TCC) After CDDP Regimen - 9MW2821 + Toripalimab vs 9MW2821 for 1st Line Locally Advanced or Metastatic Urothelial Carcinoma - 9MW2821 Combined With Toripalimab in Perioperative Patients With Urothelial Cancer - 9MW2821 in Combination With Toripalimab vs Standard Chemotherapy in Locally Advanced or Metastatic Urothelial Cancer - A Canadian Trial of Bicalutamide in Patients Receiving Maintenance Avelumab for Metastatic Urothelial Cancer. - A Clinical Study of PD-L1 Antibody ZKAB001（Drug Code） in Locally Advanced and Metastatic Urothelial Carcinoma - A Combination of Avelumab and Taxane (AVETAX) for Urothelial Cancer - A Dose Escalation and Cohort Expansion Study of NKTR-214 in Combination With Nivolumab and Other Anti-Cancer Therapies in Patients With Select Advanced Solid Tumors - A Dose Escalation Study in Solid Tumors and a Dose Expansion Study of PRN1371 in Adult Patients With Metastatic Urothelial Carcinoma - A Dose Escalation Study Of PF-06801591 In Melanoma, Head And Neck Cancer (SCCHN), Ovarian, Sarcoma, Non-Small Cell Lung Cancer, Urothelial Carcinoma or Other Solid Tumors - A Dose-escalation, Dose-finding, and Expansion Study of XL495 in Participants With Locally Advanced or Metastatic Solid Tumors - A First-in-Human Study of HH160 in Participants With Advanced or Metastatic Solid Tumors - A First-in-human Study to Evaluate the Safety and Tolerability of AZD8853 in Participants With Selected Advanced/Metastatic Solid Tumours - A Home-Based Prehabilitation Exercise Intervention for Improving Physical Function in Patients With Bladder Cancer and Upper Tract Urothelial Cancer, Get Moving Trial - A Multicenter Cancer Biospecimen Collection Study - A Multicenter Clinical Trial of Urine DNA Testing for Bladder Cancer in China - A NON-INTERVENTIONAL STUDY ON AVELUMAB USE IN PATIENTS WITH ADVANCED OR METASTATIC UROTHELIAL CARCINOMA ### Approved drugs (5) - [Atezolizumab](https://trialight.com/data/asset/atezolizumab-2cce6944-73b7-49f4-8125-4e6747997b82.md) - [Enfortumab vedotin](https://trialight.com/data/asset/enfortumab-vedotin-45d2083d-a27b-4009-b0c7-61fe813e5dea.md) - [Nivolumab](https://trialight.com/data/asset/nivolumab-d2e207ca-a7d1-43d0-987f-43ef7eef8f1b.md) - [Pembrolizumab](https://trialight.com/data/asset/pembrolizumab-f9ac1934-47a5-4a53-ae55-20b7d53d8815.md) - Vinflunine ditartrate ### Drugs in development (17) - [Cabazitaxel](https://trialight.com/data/asset/cabazitaxel-9437ae6b-3713-457c-b52b-a71e10a81dde.md) Phase 2 - [Cisplatin](https://trialight.com/data/asset/cisplatin-e039621a-d679-4740-88ac-94842bf4a91e.md) Phase 2 - [Dactolisib](https://trialight.com/data/asset/dactolisib-c690af54-bc20-4e80-bd3c-2db9669c43d1.md) Phase 2 - [Docetaxel](https://trialight.com/data/asset/docetaxel-3c835086-a86f-4a89-abb6-45847fbab5d6.md) Phase 2 - [Everolimus](https://trialight.com/data/asset/everolimus-0edf09a9-672d-4f9a-9e34-21ab083a92a4.md) Phase 2 - [Fluorouracil](https://trialight.com/data/asset/fluorouracil-f8444d73-5c73-4f35-aa71-67d578277450.md) Phase 2 - [Gemcitabine](https://trialight.com/data/asset/gemcitabine-40c84c8f-1f08-4402-bce9-f31ff283382e.md) Phase 3 - Ifosfamide Phase 2 - Lycopene Phase 2 - Mitomycin Phase 3 - [Oxaliplatin](https://trialight.com/data/asset/oxaliplatin-bd23604a-83f3-4d4c-8330-93f435fc2a0b.md) Phase 2 - [Paclitaxel](https://trialight.com/data/asset/paclitaxel-889db92c-df97-46a6-bf1c-74974a87fa75.md) Phase 2 - [Ramucirumab](https://trialight.com/data/asset/ramucirumab-5b87de8e-9f6e-425a-af38-bdf4267e4130.md) Phase 2 - Sapanisertib Phase 2 - Tesetaxel Phase 2 - Vinflunine Phase 2 - Vofatamab Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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