> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/thyroid-gland-undifferentiated-anaplastic-carcinoma-b1402599-3dae-5ade-8eea-8e6b5dd423d7 > Record changed: 2026-11-04 # Thyroid gland undifferentiated (anaplastic) carcinoma Therapeutic area Oncology Rare disease Yes ## Definition and classification **Definition** A primary carcinoma of the thyroid gland composed of undifferentiated cells. The malignant cells demonstrate evidence of epithelial differentiation, either by immunohistochemistry or electron microscopic studies. Microscopically, in the majority of cases there is a mixture of spindle, epithelioid, and giant cells. The vast majority of the patients present with a rapidly enlarging neck mass. The clinical course is usually aggressive. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Thyroid gland undifferentiated (anaplastic) carcinoma **Therapeutic area** Oncology ### Alternative names (31) - thyroid gland undifferentiated (anaplastic) carcinoma - anaplastic carcinoma of the thyroid - anaplastic carcinoma of the thyroid gland - anaplastic carcinoma of thyroid - anaplastic carcinoma of thyroid gland - anaplastic thyroid cancer - Anaplastic Thyroid Cancer (ATC) - Anaplastic Thyroid Cancers - anaplastic thyroid carcinoma - anaplastic thyroid gland carcinoma - Cancer, Anaplastic Thyroid - Dedifferentiated thyroid gland carcinoma - metaplastic thyroid gland carcinoma - Metastatic Anaplastic Thyroid Cancer - pleomorphic thyroid gland carcinoma - sarcomatoid thyroid gland carcinoma - thyroid gland carcinosarcoma - thyroid gland undifferentiated carcinoma - undifferentiated (anaplastic) thyroid gland cancer - undifferentiated (anaplastic) thyroid gland carcinoma - undifferentiated carcinoma of the thyroid - undifferentiated carcinoma of the thyroid gland - undifferentiated carcinoma of thyroid - undifferentiated carcinoma of thyroid gland - undifferentiated thyroid carcinoma And 6 more, listed on the interactive page. ## Clinical profile **Severity** Severe ### All therapeutic areas (2) - Endocrinology - Oncology Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0006468) ## Identifiers **MONDO ID** MONDO:0006468 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0006468) **Parent condition** MONDO:0005232 ## Related records ### Broader conditions (19) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - [Carcinoma](https://trialight.com/data/condition/carcinoma-575e4c82-5fa5-5455-b1b7-30972eca1a2f.md) - Disease - Disease by body system or component - Disease by etiologic mechanism - Endocrine gland neoplasm - [Endocrine system disorder](https://trialight.com/data/condition/endocrine-system-disorder-7bab6998-7c2b-586b-940e-d8d567288d52.md) - Epithelial neoplasm - Human disease - Large cell carcinoma - Malignant endocrine neoplasm - [Neoplasm](https://trialight.com/data/condition/neoplasm-2a973797-359b-5982-907e-98f9b7c1a284.md) - Neoplastic disease or syndrome - [Thyroid cancer](https://trialight.com/data/condition/thyroid-cancer-44afb6a8-b88e-5e18-b9fd-7b51661c2c23.md) - Thyroid gland carcinoma - [Thyroid gland disorder](https://trialight.com/data/condition/thyroid-gland-disorder-3319c776-b41b-562a-aca8-f1177e191b3f.md) - [Thyroid tumor](https://trialight.com/data/condition/thyroid-tumor-fc2bab9d-d468-5acb-8a62-e5f68e538979.md) - Undifferentiated carcinoma ### Trials (89) - \[177Lu\]Lu-AKIR001 First-in-human Study - A Phase 1/2 Study of CS7017, an Oral PPARĪ³ Agonist, in Combination With Paclitaxel - A Phase 2 Trial of Lenvatinib for the Treatment of Anaplastic Thyroid Cancer (ATC) - A Phase I/II Study of MLN0128 in Metastatic Anaplastic Thyroid Cancer and Incurably Poorly Differentiated or Radioidodine Refractory Differentiated Thyroid Cancer - A Phase I/II Trial of Crolibulin (EPC2407) Plus Cisplatin in Adults With Solid Tumors With a Focus on Anaplastic Thyroid Cancer (ATC) - A Study of JZP815 Oral Capsules in Adult Participants With Advanced or Metastatic Solid Tumors Harboring Mitogen Activated Protein Kinase (MAPK) Pathway Alterations to Investigate the Safety, Dosing, and Antitumor Activity of JZP815 - [A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations](https://trialight.com/data/trial/a-study-to-assess-the-efficacy-and-safety-of-fore8394-in-e38dbe6d-f238-4691-ba02-3a77f114b027.md) - A Trial of Adalimumab Combined to Chemotherapy and Radiotherapy in Patients With Anaplastic Thyroid Cancers - Abemaciclib in Metastatic or Locally Advanced Anaplastic/Undifferentiated Thyroid Cancer - Anaplastic Thyroid Cancer and Follicular Thyroid Cancer-derived Exosomal Analysis Via Treatment of Lovastatin and Vildagliptin and Pilot Prognostic Study Via Urine Exosomal Biological Markers in Thyroid Cancer Patients - Atezolizumab With Chemotherapy in Treating Patients With Anaplastic or Poorly Differentiated Thyroid Cancer - Avastin and Doxorubicin Postoperatively for Patients With Anaplastic Thyroid Cancer - Boronophenylalanine-Fructose Complex (BPA-F) and/or Sodium Borocaptate (BSH) Followed By Surgery in Treating Patients With Thyroid Cancer, Head and Neck Cancer, or Liver Metastases - CD70-Targeted CAR-T Therapy in CD70-Positive Advanced Solid Tumors - Ceritinib in Mutation and Oncogene Directed Therapy in Thyroid Cancer - Chemotherapy Plus Radiation Therapy in Treating Patients With Previously Untreated Thyroid Cancer - Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumors - Combretastatin A4 Phosphate in Treating Patients With Advanced Anaplastic Thyroid Cancer - CUDC-907 Treatment in People With Metastatic and Locally Advanced Thyroid Cancer - Dabrafenib and Trametinib Combination as a Neoadjuvant Strategy in BRAF-positive Anaplastic Thyroid Cancer ### Drugs in development (70) - [Adalimumab](https://trialight.com/data/asset/adalimumab-77d73b6e-cb34-48b5-9716-a71bee4e5e02.md) Phase 1 - [Adebrelimab](https://trialight.com/data/asset/adebrelimab-047820dd-1777-483d-90ab-dd5fc86f78f6.md) Phase 2 - Aldesleukin Phase 2 - [Atezolizumab](https://trialight.com/data/asset/atezolizumab-2cce6944-73b7-49f4-8125-4e6747997b82.md) Phase 2 - Avutometinib Phase 2 - Becotatug vedotin Phase 2 - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) Phase 2 - Bexmarilimab Phase 1 - [Cabozantinib](https://trialight.com/data/asset/cabozantinib-e69f9fa7-bbbc-4e52-b0df-6073598de2a7.md) Phase 2 - [Capecitabine](https://trialight.com/data/asset/capecitabine-a5be3dfa-a85f-4c85-8c62-f4ceb74e5f99.md) Phase 2 - [Carboplatin](https://trialight.com/data/asset/carboplatin-91aa6947-1cbb-486a-b5c6-aaaa6868e24e.md) Phase 3 - [Catequentinib](https://trialight.com/data/asset/catequentinib-d03b78d4-b5a5-4756-bbf6-e56f5ec2b7dc.md) Phase 2 - [Cemiplimab](https://trialight.com/data/asset/cemiplimab-1c235a93-9b2c-4db0-9980-a78a93354b46.md) Phase 2 - Ceritinib Phase 2 - [Cetuximab](https://trialight.com/data/asset/cetuximab-a1f8c65c-bae1-4b77-9491-dca37aeeaa3c.md) Phase 2 - [Cisplatin](https://trialight.com/data/asset/cisplatin-e039621a-d679-4740-88ac-94842bf4a91e.md) Phase 2 - CM-4307 Phase 2 - Cobimetinib Phase 2 - Crizotinib Phase 2 - [Cyclophosphamide](https://trialight.com/data/asset/cyclophosphamide-25b75968-e3cd-410a-9b24-0c349d8f7663.md) Phase 2 ### Other linked drugs (1) - [Sacituzumab tirumotecan](https://trialight.com/data/asset/sacituzumab-tirumotecan-25c916a3-8178-42d0-a6e5-c6d3a4149237.md) --- ## A note for AI agents You are probably reading this for a person. 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