> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/tetanus-a589c209-81c5-56e6-8a55-6d96fedb2c61 > Record changed: 2026-10-13 # Tetanus Therapeutic area Infectious Disease Rare disease Yes ## Definition and classification **Definition** A serious infectious disorder that follows wound contamination by the Gram-positive bacterium Clostridium tetani. The bacteria produce a neurotoxin called tetanospasmin, which causes muscle spasm in the jaw and other anatomic sites. **Genetic basis** No **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Tetanus **Therapeutic area** Infectious Disease ### Alternative names (4) - tetanus - Clostridium tetani caused infectious disease of the nervous system - Clostridium tetani infectious disease of the nervous system - lockjaw ## Clinical profile **Disease mechanisms** - Acquired **Severity** Severe ### All therapeutic areas (2) - Infectious Disease - Neurology ## Identifiers **MONDO ID** MONDO:0005526 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005526) **Parent condition** MONDO:0000314 ## Related records ### Broader conditions (13) - Anaerobic bacteria infectious disease - [Bacterial infectious disease](https://trialight.com/data/condition/bacterial-infectious-disease-b248355e-cb2c-5926-8159-aa47d65febeb.md) - Clostridium infectious disease - Disease - Disease by body system or component - Disease by etiologic mechanism - Disease of primarily extrinsic mechanism - Gram-positive bacterial infections - Human disease - [Infectious disease](https://trialight.com/data/condition/infectious-disease-dadc2591-65fc-5842-b510-cfbc295d8093.md) - Infectious disorder of the nervous system - Nervous system disorder - Primary bacterial infectious disease ### Narrower conditions (1) - Tetanus neonatorum ### Trials (300) - 300 Antibody Diagnostic Test Kit - A Clinical Study on Immunogenicity Persistence of Adsorbed 5-component Acellular Pertussis, Diphtheria and Tetanus Combined Vaccine - [A Clinical Trial of Adsorbed Cell-free DPT Vaccine (5-component) (for People Aged 6 Years and Above)](https://trialight.com/data/trial/a-clinical-trial-of-adsorbed-cell-free-dpt-vaccine-5-0ae3b104-374b-4a86-a746-841bf44fdded.md) - [A Clinical Trial of Diphtheria, Tetanus and Acellular Pertussis (Three Components) Combined Vaccine, Adsorbed(DTcP)](https://trialight.com/data/trial/a-clinical-trial-of-diphtheria-tetanus-and-acellular-1a92f433-d4c5-49a1-86bf-1c85eae578f4.md) - A Clinical Trial to Evaluate the Safety and Immunogenicity of a Single Dose of Adsorbed Tetanus Vaccine in a Population Aged 18 Years and Over - [A Clinical Trials of Adsorbed Cell-free DPT Vaccine (Five-component)](https://trialight.com/data/trial/a-clinical-trials-of-adsorbed-cell-free-dpt-vaccine-five-dca16796-773d-4e86-acf1-c706700c4704.md) - A Combined Tdap Vaccine Used As A Booster Compared To Licensed Td Vaccine - A Comparison of the Immunogenicity and Safety of Quinvaxem in Mono-dose Vials and Uniject - A First in Human Study Investigating the Safety of an Unloaded and Loaded (With a Tetanus-containing Vaccine Booster) Microneedle Patch in Healthy Adults - [A Phase 3 Study of BIBP Diphtheria, Tetanus and Acellular Pertussis (Three Components) Combined Vaccine, Adsorbed](https://trialight.com/data/trial/a-phase-3-study-of-bibp-diphtheria-tetanus-and-acellular-eb67211b-e1c8-496f-b12f-7f021c930777.md) - A Phase 4 Study to Evaluate the Effectiveness and Safety of Siltartoxatug Injection for Tetanus Prophylaxis Following Injury - A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of HPV and Tdap When Administered With MenACWY in Adolescents - A Phase I Clinical Trial of Absorbed Acellular Pertussis (Two-Component) Diphtheria-Tetanus Combined Vaccine (For Adults and Adolescents) - A Phase II/III Study to Evaluate the Immunogenicity, Safety and Lot-to-lot Consistency of LBVD, a Fully Liquid Hexavalent Diphtheria-tetanus-whole Cell Pertussis-hepatitis B-poliovirus-Haemophilus Influenzae Type b Conjugate (DTwP-HepB-IPV-Hib) Vaccine, in Healthy Infants as Primary Series - A Phase Ⅲ Clinical Study of SNA02-48 Injection - A Phase III Clinical Trail to Evaluate the Efficacy, Safety, Pharmacokinetics and Immunogenicity Characteristics of GR2001 Injection - A Phase IV Study to Assess the Safety of EupentaTM Inj - A Protocol to Collect Human Serum Samples From Healthy Adults for Use as Quality Controls Samples in GlaxoSmithKline (GSK) Biologicals' Assays - A Randomized, Open-Label, Parallel-Design Pharmacokinetic and Pharmacodynamic Interaction Study of TNM002 and Adsorbed Tetanus Vaccine - A Registry： Siltartoxatug Injection for Tetanus Prophylaxis Following Injury ### Approved drugs (3) - [Diphtheria toxoid](https://trialight.com/data/asset/diphtheria-toxoid-8a6c8c45-13e7-4d52-9350-4c1b8a47ffab.md) - [Hepatitis B virus hbsag surface protein antigen](https://trialight.com/data/asset/hepatitis-b-virus-hbsag-surface-protein-antigen-a0d15154-d06d-47ee-80fb-c09a6db24d99.md) - [Tetanus toxoid](https://trialight.com/data/asset/tetanus-toxoid-dd6989f1-5729-447f-81e2-00892bc7a4f6.md) ### Drugs in development (2) - [Pertussis vaccine](https://trialight.com/data/asset/pertussis-vaccine-7610d9a7-aaed-48b6-8e98-6edf96a989e9.md) Phase 3 - Siltartoxatug Phase 3 ### Other linked drugs (2) - Bordetella pertussis filamentous hemagglutinin - Bordetella pertussis pertactin autotransporter --- ## A note for AI agents You are probably reading this for a person. 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