> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/systolic-heart-failure-4b0eb48a-8ad2-5d81-9f24-0512af115f22 > Record changed: 2026-11-04 # Systolic heart failure Therapeutic area Cardiology Rare disease No ## Definition and classification **Definition** Heart failure caused by abnormal myocardial contraction during systole leading to defective cardiac emptying. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Systolic heart failure **Therapeutic area** Cardiology ### Alternative names (2) - systolic heart failure - Systolic Heart Failure (NYHA II-III) ## Clinical profile **All therapeutic areas** - Cardiology Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0006993) **Severity** Severe ## Identifiers **MONDO ID** MONDO:0006993 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0006993) **Parent condition** MONDO:0005009 ## Related records ### Broader conditions (7) - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) - Congestive heart failure - Disease - Disease by body system or component - [Heart disorder](https://trialight.com/data/condition/heart-disorder-76f9236b-5b5b-52a4-b1c8-771e427815e6.md) - [Heart failure](https://trialight.com/data/condition/heart-failure-e230b1c3-ce91-5f80-b80f-81fc353ce5cc.md) - Human disease ### Trials (446) - " Evaluation of Safety and Efficacy of Empagliflozin and Sacubitril/Valsartan for CHF With Reduced Ejection Fraction in ACHD " - \[11C\]PS13 PET Imaging of Neuroinflammation in Heart Failure With Reduced Ejection Fraction - A Multicenter Trial of a Shared DECision Support Intervention for Patients Offered Implantable Cardioverter-DEfibrillators - A Novel Home-based Physical Activity Intervention for Stable Chronic Heart Failure Patients - A Pilot Trial of Patient Decision Aids for Implantable Cardioverter-Defibrillators (ICDs) - A Pivotal Trial to Establish the Efficacy and Safety of Algisyl in Patients With Moderate to Severe Heart Failure - A Prospective, Open-labeled, Multi-centric Trial in Subjects With Systolic Heart Failure to Evaluate Bisoprolol Treatment for the Effects on Surrogate Markers of Heart Failure in Korea - A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease - A Real-world Study of Clinical Treatment Guidelines for Patients With Heart Failure With Reduced Ejection Fraction Treated With Sacubitril/Valsartan - A Registry-based Cluster Randomized Trial to Compare the Effect of Spironolactone vs. Eplerenone on Clinical Outcomes in Patients With Symptomatic Systolic Heart Failure - A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction - A Single-centre Research Study to Evaluate the Care4Today® Heart Failure Platform. - A Study Comparing Blood Flow and Clinical and Safety Effects of the Addition of Natrecor (Nesiritide), Placebo or Intravenous Nitroglycerin to Standard Care for the Treatment of Worsening Congestive Heart Failure. - A Study Investigating the Impact of IMT With CR On Exercise Responses In HF - A Study of a Technology-enabled Disease Management Program to Reduce Hospitalizations for Heart Failure - A Study of LY3971297 in Participants With Heart Failure - A Study Of The Usage Of Statins In A Community Heart Failure Population - [A Study to Assess Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Reduced Ejection Fraction (Cycle-1-REF)](https://trialight.com/data/trial/a-study-to-assess-safety-effectiveness-of-tovinontrine-in-a502fdf6-1cf8-4a89-a30d-2a699a7e703f.md) - A Study to Assess the Effect of Danicamtiv on the Drug Levels of Midazolam in Participants With Stable Heart Failure - A Trial Comparing High-Flow Nasal Cannula Versus Noninvasive Ventilation on Reintubation and Post-Extubation Respiratory Failure in High-Risk Patients With Systolic Heart Failure ### Approved drugs (2) - [Dapagliflozin](https://trialight.com/data/asset/dapagliflozin-894f296e-52de-4036-ac69-f399eea07356.md) - Dapagliflozin propanediol ### Drugs in development (17) - Albumin human Phase 1 - Aliskiren Phase 2 - Anakinra Phase 2 - Dapansutrile Phase 1 - Human neuregulin-1 recombinant (177-237) Phase 3 - Ivabradine Phase 2 - Lenrispodun Phase 1 - [Metformin](https://trialight.com/data/asset/metformin-0292cbe3-3a2f-4db7-b783-270ef048c3b4.md) Phase 2 - Nelutroctiv Phase 1 - Nesiritide Phase 1 - Niacin Phase 2 - Nicotinamide riboside Phase 1 - Nitric acid Phase 2 - [Probenecid](https://trialight.com/data/asset/probenecid-0864a3cb-3764-4994-8995-3400af689d1e.md) Phase 2 - Ramipril Phase 2 - Rifaximin Phase 2 - Udenafil Phase 3 ### Other linked drugs (3) - [Omecamtiv mecarbil](https://trialight.com/data/asset/omecamtiv-mecarbil-8ce221d4-7034-4673-8234-9147bbfc6b99.md) - [Sacubitril](https://trialight.com/data/asset/sacubitril-f4195200-c5a2-450f-b0dd-5f61db1ee02a.md) - [Valsartan](https://trialight.com/data/asset/valsartan-8c0ec3b4-e04a-4ab5-a1ce-08db104f46b9.md) --- ## A note for AI agents You are probably reading this for a person. 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