> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/systemic-lupus-erythematosus-6c9d074f-cc5f-588b-bf0c-6338d30c6eac > Record changed: 2026-10-13 # Systemic lupus erythematosus Therapeutic area Immunology Rare disease Yes ## Definition and classification **Definition** An autoimmune multi-organ disease typically associated with vasculopathy and autoantibody production. Most patients have antinuclear antibodies (ANA). The presence of anti-dsDNA or anti-Smith antibodies are highly-specific. **Genetic basis** Yes **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Systemic lupus erythematosus **Therapeutic area** Immunology ### Alternative names (9) - systemic lupus erythematosus - Lupus - SLE - SLE - lupus erythematosus, systemic - disseminated lupus erythematosus - lupus erythematosus, systemic - systemic lupus erythematosus - systemic lupus erythematosus (disease) - systemic lupus erythematosus susceptibility to ## Clinical profile **Severity** Severe ### Disease mechanisms (2) - Genetic - Hereditary ### All therapeutic areas (2) - Immunology - Rheumatology ## Identifiers **MONDO ID** MONDO:0007915 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0007915) **Parent condition** MONDO:0004670 ## Related records ### Broader conditions (12) - [Autoimmune disease](https://trialight.com/data/condition/autoimmune-disease-8a8fd8aa-2d04-5f24-b839-ba96a70c11e9.md) - [Connective tissue disorder](https://trialight.com/data/condition/connective-tissue-disorder-3df54ecd-c080-5b4c-b60d-fab4846ea17b.md) - Disease - Disease by body system or component - Disease by etiologic mechanism - Disease of genetic or genomic mechanism - Hereditary disease - Hereditary disorder of connective tissue - Human disease - [Immune system disorder](https://trialight.com/data/condition/immune-system-disorder-24846188-b462-515c-bb34-142255a648c8.md) - Lupus erythematosus - [Rheumatic disorder](https://trialight.com/data/condition/rheumatic-disorder-e863530e-2c28-5a33-b1be-d12fa4d746b9.md) ### Narrower conditions (12) - Autosomal systemic lupus erythematosus type 16 - Bullous systemic lupus erythematosus - Central nervous system lupus - Neonatal lupus erythematosus - Pediatric systemic lupus erythematosus - Systemic lupus erythematosus 17 - Systemic lupus erythematosus 18 - Systemic lupus erythematosus related to C1QA - Systemic lupus erythematosus related to C1QB - Systemic lupus erythematosus related to C1QC - Systemic lupus erythematosus related to C1S - Systemic lupus erythematosus related to C4A ### Trials (1,247) - " TREX1 Gene Mutations and Their Role in Systemic Lupus Erythematosus - (Anti-Ribosomal P Protein,Anti-U1 RNP, Anti-Nucleosome and Anti-ds DNA Antibodies) and Relation to Depression and Anxiety in SLE - 2-HOBA in Systemic Lupus Erythematosus - 3,3'-Diindolylmethane in Patients With Systemic Lupus Erythematosus - 3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus Erithematosus Study Protocol - 3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus Erythematosus Study Protocol 2 - A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus - A 52-Week, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Evaluate the Efficacy and Safety of a 200-mcg Dose of IPP-201101 Plus Standard of Care in Patients With Systemic Lupus Erythematosus - A Basket Study of CTA313 in Participants With Active Autoimmune Diseases - A Clinica Study of SCTC21C in Participants With Systemic Lupus Erythematosus - A Clinical Study Exploring the Safety, Efficacy and Cell Metabolic Dynamics of Universal CD19 / 20 Car-t Cell Injection in Moderate to Severe Refractory Systemic Lupus Erythematosus - A Clinical Study of CD19 CAR-T in Active Systemic Lupus Erythematosus - A Clinical Study of CD19 Universal CAR-γδT Cells in Active Systemic Lupus Erythematosus - A Clinical Study of Dual-Target, Universal CAR-T Cell Therapy for Refractory Systemic Lupus Erythematosus - A Clinical Study of MK-1045 in People With Lupus or Rheumatoid Arthritis (MK-1045-004) - A Clinical Study of TI-0032-III Injection in Patients With Relapsed and Refractory Autoimmune Diseases - A Clinical Study of YTS109 Cell for R/R Autoimmune Diseases - A Clinical Study of YTS109 Cell in R/R Autoimmune Diseases - A Clinical Study of YTS109 Cells for the Treatment of R/R Autoimmune Diseases - A Clinical Study to Evaluate LVIVO-TaVec400 for the Treatment of Relapsed/Refractory Autoimmune Diseases ### Approved drugs (7) - [Anifrolumab](https://trialight.com/data/asset/anifrolumab-4df440fe-efd0-44aa-828f-ea4381468125.md) - Belimumab - Cortisone acetate - [Dexamethasone](https://trialight.com/data/asset/dexamethasone-b923ddae-f095-408c-96e9-975238a429ad.md) - Dexamethasone sodium phosphate - [Prednisolone](https://trialight.com/data/asset/prednisolone-783fce19-b285-4835-90c3-3db5a6364414.md) - [Prednisone](https://trialight.com/data/asset/prednisone-a5a99f90-5fbe-45c2-a625-34ba78735da6.md) ### Drugs in development (155) - [Abatacept](https://trialight.com/data/asset/abatacept-a318efa4-5922-464c-8f45-90c18515f1c5.md) Phase 2 - Abetimus sodium Phase 3 - Abrocitinib Phase 2 - Acazicolcept Phase 1 - [Acetaminophen](https://trialight.com/data/asset/acetaminophen-04ea33a5-49ee-4a1b-ad16-54627012140e.md) Phase 3 - Acetylcysteine Phase 2 - Afimetoran Phase 1 - Aldesleukin Phase 3 - [Alnuctamab](https://trialight.com/data/asset/alnuctamab-4489c89d-75f0-45e1-a898-dacda22f155a.md) Phase 1 - AMG-557 Phase 1 - AMG-811 Phase 1 - Amiselimod hydrochloride Phase 1 - APG-2575 Phase 1 - Arsenic trioxide Phase 2 - Artenimol Phase 2 - [Aspirin](https://trialight.com/data/asset/aspirin-03870fc6-137e-47aa-9f14-b7ae6754fb15.md) Phase 2 - [Atacicept](https://trialight.com/data/asset/atacicept-58997791-8042-4d0f-ac69-564cf9e78d1d.md) Phase 2 - Atorvastatin Phase 3 - Avizakimab Phase 1 - Azathioprine Phase 3 ### Other linked drugs (4) - Budoprutug - Calcium - Duloxetine hydrochloride - Modafinil --- ## A note for AI agents You are probably reading this for a person. 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