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Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/synucleinopathy-e1b73971-9675-5fb3-8d78-0d53ad234cca > Record changed: 2026-11-04 # Synucleinopathy Therapeutic area Metabolic Disease Rare disease No ## Definition and classification **Definition** A neurodegenerative disease that is characterized by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibers or glial cells. \[url:http://en.wikipedia.org/wiki/Synucleinopathies \] **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Synucleinopathy **Alternative names** - synucleinopathy **Therapeutic area** Metabolic Disease ## Clinical profile **Severity** Severe ### All therapeutic areas (2) - Metabolic Disease - Neurology Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0000510) ## Identifiers **MONDO ID** MONDO:0000510 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0000510) **Parent condition** MONDO:0005559 ## Related records ### Broader conditions (10) - [Central nervous system disorder](https://trialight.com/data/condition/central-nervous-system-disorder-78230ae5-4e6b-5495-ac04-050b0e11e964.md) - Disease - Disease by body system or component - Disease by developmental or physiological process - Disease by molecular mechanism - Human disease - [Metabolic disease](https://trialight.com/data/condition/metabolic-disease-3d73c19d-b8c8-5be8-add5-77c7d794dacd.md) - [Nervous system disorder](https://trialight.com/data/condition/nervous-system-disorder-541eb3ed-9656-574d-babf-28139b060a42.md) - [Neurodegenerative disease](https://trialight.com/data/condition/neurodegenerative-disease-aafbeed5-19eb-5b92-ae0b-73cbafb719c7.md) - Proteostasis deficiencies ### Narrower conditions (12) - Autosomal dominant striatal neurodegeneration type 1 - Familial infantile bilateral striatal necrosis - [Lewy body dementia](https://trialight.com/data/condition/lewy-body-dementia-eaa4788b-4d65-5d2f-add5-502d935893c0.md) - Multiple system atrophy - Multiple system atrophy, cerebellar type - Multiple system atrophy, parkinsonian type - Pure autonomic failure - Striatal degeneration, autosomal dominant - Striatal degeneration, autosomal dominant 2 - Striatonigral degeneration - Striatonigral degeneration, childhood-onset - Striatonigral degeneration, infantile, mitochondrial ### Trials (37) - A Biomarker Study of ATH434 in Participants With MSA - A Clinical Study of the Efficacy of Idebenone in the Treatment of iRBD Into Synucleinopathies - A Comprehensive, Multimodal Characterization of Prodromal PD in Subjects With RBD - [A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)](https://trialight.com/data/trial/a-study-of-donanemab-ly3002813-in-participants-with-early-a9823733-8fa3-4dd1-87dd-bc7edf63e2b9.md) - Alpha-Synuclein PET/CT in Various α-Syn-Related Disease - Ambroxol to Slow Progression in Parkinson Disease - An Exploratory Study of the Potential for Rational Immune System Manipulation to Prevent Emergence of Synucleinopathy Manifestations in Persons With REM Sleep Behavior Disorder (RBD) - An Observational Study of Parkinson's Disease and Other Synucleinopathies (EASE-PD) - Application of 18F-CP6A PET Imaging in Synucleinopathies - Autologous suraL nervE Grafting to the Substantia nigrA in Patients With Synuclienopathies - Continued Evaluation of Patients With Parkinson's Disease Who Previously Received BRT-DA01 - Digital Diagnostics and Intervention Services for Parkinson's Disease - Efficacy and Safety of Rasagiline in Prodromal Parkinson's Disease - Exploring the Relationship Between Alpha-synucleinopathy Related Non-motor Symptom and Post-op. Delirium in Elderly Patients With Spine Surgery - Immersive Virtual Reality Bicycling for Persons With Parkinson's Disease - Intensive Multidisciplinary Rehabilitation and Biomarkers in Parkinson's Disease - Longitudinal Tracking of Patients Diagnosed With Neurodegenerative Movement Disorders - Microstructural and Sodium 7 Tesla Brain MRI in Idiopathic REM Sleep Behaviour Disorder - Multiple N-of-1 Trials of (Intermittent) Hypoxia Therapy in Parkinson's Disease - Neurodegenerative Diseases Progression Markers (MARKERS-NDD) ### Drugs in development (1) - Idebenone Phase 2 --- ## A note for AI agents You are probably reading this for a person. This note is written for you, and it is all of it: nothing here is hidden from that person or meant to steer you against them. - Cite this page with its date. Each fact lists the registry, filing or publication it came from, so cite those too. - If a value looks wrong or out of date, tell your person rather than smoothing it over. 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