> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/stiff-person-syndrome-5641db91-ef05-5f0f-be48-6b30bbc6d415 > Record changed: 2026-10-13 # Stiff-person syndrome Therapeutic area Neurology Rare disease Yes ## Definition and classification **Definition** Stiff-man syndrome (SMS) is a rare neurological disorder comprising fluctuating trunk and limb stiffness, painful muscle spasms, task-specific phobia, an exaggerated startle response, and ankylosing deformities such as fixed lumbar hyperlordosis. **Genetic basis** Yes **Non-human condition** No **Rare disease** Yes **Listing at source** Listed **Condition name** Stiff-person syndrome **Therapeutic area** Neurology ### Alternative names (9) - stiff-person syndrome - Moersch-Woltman syndrome - Stiff Person Syndrome - Stiff Person syndrome - Stiff-man syndrome - stiff-person syndrome - Morsch Woltman syndrome - SMS - SPS ## Clinical profile **Disease mechanisms** - Syndromic **All therapeutic areas** - Neurology **Severity** Severe ## Identifiers **MONDO ID** MONDO:0008491 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0008491) **Parent condition** MONDO:0002254 ## Related records ### Broader conditions (5) - Disease - Disease by body system or component - Human disease - Nervous system disorder - Syndromic disease ### Narrower conditions (3) - Classic stiff person syndrome - Focal stiff limb syndrome - Progressive encephalomyelitis with rigidity and myoclonus ### Trials (18) - A Long-Term Follow-Up Study for Participants Previously Treated With KYV-101 - [A Phase 1 Study of Prulacabtagene Leucel (Prula-cel, Formerly ADI-001) in Autoimmune Disease](https://trialight.com/data/trial/a-phase-1-study-of-prulacabtagene-leucel-prula-cel-formerly-0aebce17-d67c-419f-b24a-9fff94392a5e.md) - A Study Investigating Intravenous Human Normal Immune Globulin 10% in Adults With Stiff Person Syndrome - A Study of C-CAR168 in the Treatment of Central Nervous System Autoimmune Diseases Refractory to Standard Therapy - Autologous Stem Cell Transplant for Neurologic Autoimmune Diseases - Baby Detect : Genomic Newborn Screening - Biomarkers in Autoimmune Disease of Nervous System - Cause, Development, and Progression of Stiff-Person Syndrome - Efficacy and Mechanism of Action of SCIg in Patients With Stiff Person Syndrome (SPS) - Efgartigimod for Stiff Person Syndrome (ESPS) - Evaluating Spinal Cord Stimulation for Stiff Person Syndrome - Extracorporeal Photopheresis (ECP) in the Treatment of Stiff Person Syndrome (OPTION Study) - HLA Analysis in Autoimmune Encephalitis and Related Disorders - Intravenous Immunoglobulin (IVIg) for the Treatment of Stiff-Man Syndrome (SMS) - KYSA-8: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Therapy, in Subjects With Treatment Refractory Stiff Person Syndrome - Randomized Placebo Controlled Trial of IVIg in Glycine Receptor Antibody Positive Stiff-person Syndrome - Rituximab to Treat Stiff Person Syndrome - Stem Cell Transplantation for Stiff Person Syndrome (SPS) ### Approved drugs (1) - [Diazepam](https://trialight.com/data/asset/diazepam-a0cb3123-d888-4bf4-b90a-171c1dcecccb.md) ### Drugs in development (12) - Carmustine Phase 2 - [Cyclophosphamide](https://trialight.com/data/asset/cyclophosphamide-25b75968-e3cd-410a-9b24-0c349d8f7663.md) Phase 1 - Cytarabine Phase 2 - Efgartigimod alfa Phase 2 - Etoposide Phase 2 - [Filgrastim](https://trialight.com/data/asset/filgrastim-942bf0d3-0bf1-4bf8-9e38-81a6c277d728.md) Phase 1 - [Human immunoglobulin G](https://trialight.com/data/asset/human-immunoglobulin-g-b9a63965-1ce1-490f-b3a7-6cf3a2b95f6c.md) Phase 3 - Melphalan Phase 2 - Mesna Phase 1 - [Methylprednisolone](https://trialight.com/data/asset/methylprednisolone-f881999e-4ad3-485a-8fbe-6e7b979365f9.md) Phase 1 - [Prednisone](https://trialight.com/data/asset/prednisone-a5a99f90-5fbe-45c2-a625-34ba78735da6.md) Phase 2 - [Rituximab](https://trialight.com/data/asset/rituximab-3fb73477-f618-414e-aa0a-9ccba4d6da3f.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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