Stiff-person syndrome
Therapeutic area
Neurology
Rare disease
Yes
- Definition
- Stiff-man syndrome (SMS) is a rare neurological disorder comprising fluctuating trunk and limb stiffness, painful muscle spasms, task-specific phobia, an exaggerated startle response, and ankylosing deformities such as fixed lumbar hyperlordosis.
- Genetic basis
- Yes
- Non-human condition
- No
- Rare disease
- Yes
- Listing at source
- Listed
- Condition name
- Stiff-person syndrome
- Therapeutic area
- Neurology
- stiff-person syndrome
- Moersch-Woltman syndrome
- Stiff Person Syndrome
- Stiff Person syndrome
- Stiff-man syndrome
- stiff-person syndrome
- Morsch Woltman syndrome
- SMS
- SPS
- Disease mechanisms
- Syndromic
- All therapeutic areas
- Neurology
- Severity
- Severe
- MONDO ID
- MONDO:0008491
- Parent condition
- MONDO:0002254
Related records
Broader conditions (5)
- Disease
- Disease by body system or component
- Human disease
- Nervous system disorder
- Syndromic disease
Narrower conditions (3)
- Classic stiff person syndrome
- Focal stiff limb syndrome
- Progressive encephalomyelitis with rigidity and myoclonus
Trials (18)
- A Long-Term Follow-Up Study for Participants Previously Treated With KYV-101
- A Phase 1 Study of Prulacabtagene Leucel (Prula-cel, Formerly ADI-001) in Autoimmune Disease
- A Study Investigating Intravenous Human Normal Immune Globulin 10% in Adults With Stiff Person Syndrome
- A Study of C-CAR168 in the Treatment of Central Nervous System Autoimmune Diseases Refractory to Standard Therapy
- Autologous Stem Cell Transplant for Neurologic Autoimmune Diseases
- Baby Detect : Genomic Newborn Screening
- Biomarkers in Autoimmune Disease of Nervous System
- Cause, Development, and Progression of Stiff-Person Syndrome
- Efficacy and Mechanism of Action of SCIg in Patients With Stiff Person Syndrome (SPS)
- Efgartigimod for Stiff Person Syndrome (ESPS)
- Evaluating Spinal Cord Stimulation for Stiff Person Syndrome
- Extracorporeal Photopheresis (ECP) in the Treatment of Stiff Person Syndrome (OPTION Study)
- HLA Analysis in Autoimmune Encephalitis and Related Disorders
- Intravenous Immunoglobulin (IVIg) for the Treatment of Stiff-Man Syndrome (SMS)
- KYSA-8: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Therapy, in Subjects With Treatment Refractory Stiff Person Syndrome
- Randomized Placebo Controlled Trial of IVIg in Glycine Receptor Antibody Positive Stiff-person Syndrome
- Rituximab to Treat Stiff Person Syndrome
- Stem Cell Transplantation for Stiff Person Syndrome (SPS)
Approved drugs (1)
Drugs in development (12)
- Carmustine Phase 2
- Cyclophosphamide Phase 1
- Cytarabine Phase 2
- Efgartigimod alfa Phase 2
- Etoposide Phase 2
- Filgrastim Phase 1
- Human immunoglobulin G Phase 3
- Melphalan Phase 2
- Mesna Phase 1
- Methylprednisolone Phase 1
- Prednisone Phase 2
- Rituximab Phase 2