> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/squamous-cell-lung-carcinoma-9debeb10-0511-5be7-aeaa-3901bc5b9a67 > Record changed: 2026-10-13 # Squamous cell lung carcinoma Therapeutic area Oncology Rare disease No ## Definition and classification **Definition** A carcinoma arising from squamous bronchial epithelial cells. It may be keratinizing or non-keratinizing. Keratinizing squamous cell carcinoma is characterized by the presence of keratinization, pearl formation, and/or intercellular bridges. Non-keratinizing squamous cell carcinoma is characterized by the absence of keratinization, pearl formation, and intercellular bridges. Cigarette smoking and arsenic exposure are strongly associated with squamous cell lung carcinoma. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Squamous cell lung carcinoma **Therapeutic area** Oncology ### Alternative names (9) - squamous cell lung carcinoma - epidermoid cell carcinoma of lung - epidermoid cell carcinoma of the lung - epidermoid cell lung carcinoma - lung squamous cell carcinoma - squamous cell carcinoma of lung - squamous cell carcinoma of the lung - squamous cell lung cancer - squamous cell lung carcinoma ## Clinical profile **Severity** Severe ### All therapeutic areas (2) - Oncology - Pulmonology ## Identifiers **MONDO ID** MONDO:0005097 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005097) **Parent condition** MONDO:0005096 ## Related records ### Broader conditions (22) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - [Carcinoma](https://trialight.com/data/condition/carcinoma-575e4c82-5fa5-5455-b1b7-30972eca1a2f.md) - Disease - Disease by body system or component - Disease by etiologic mechanism - [Epithelial neoplasm](https://trialight.com/data/condition/epithelial-neoplasm-5584692a-5e9d-58e1-9432-db6264993a80.md) - Human disease - [Lower respiratory tract disorder](https://trialight.com/data/condition/lower-respiratory-tract-disorder-cfa96f5e-8af8-555b-a663-55befbd68962.md) - [Lung cancer](https://trialight.com/data/condition/lung-cancer-c4ca1fe0-9b3d-5957-a668-2d6cf26bd16a.md) - [Lung carcinoma](https://trialight.com/data/condition/lung-carcinoma-8cf46a3c-0bd0-5247-adda-142fcb8391aa.md) - [Lung disorder](https://trialight.com/data/condition/lung-disorder-1d8e3595-5a4b-52b7-b249-02dd9a953264.md) - [Lung neoplasm](https://trialight.com/data/condition/lung-neoplasm-d4ce75ac-7517-5ab7-9f47-34c0f7b81786.md) - Neoplasm - Neoplasm of thorax - Neoplastic disease or syndrome - Respiratory system cancer - Respiratory system disorder - [Respiratory tract neoplasm](https://trialight.com/data/condition/respiratory-tract-neoplasm-2d8277a2-2395-521a-b14a-4b620139fe2d.md) - [Squamous cell carcinoma](https://trialight.com/data/condition/squamous-cell-carcinoma-44944de3-3c1f-5714-9da2-a28db7d896c2.md) ### Narrower conditions (3) - Adenosquamous lung carcinoma - Lung occult squamous cell carcinoma - Non-small cell squamous lung carcinoma ### Trials (116) - A Clinical Study of SI-B001 Combined With Docetaxel in the Treatment of Non-small Cell Lung Adenocarcinoma and Lung Squamous Cell Carcinoma - A Non-interventional Study With Advanced Lung Squamous Cell Carcinoma - A Phase 1 Study in Participants With Advanced Cancer - A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations - A Phase II, Open Label, Multiple Arm Study of AUY922, BYL719, INC280, LDK378 and MEK162 in Chinese Patients With Advanced Non-small Cell Lung Cancer - A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas - A Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of TT125-802 in Subjects With Advanced Solid Tumors - A Study of Anti-PD-1 AK105 in Patients With Metastatic Squamous Non-small Cell Lung Cancer - A Study of AZD2014 in Combination With Selumetinib in Patients With Advanced Cancers - A Study of Endostar Combined With Chemotherapy and Immunotherapy in Lung Squamous Cell Carcinom - A Study of Pemetrexed Plus Cisplatin With Concurrent Radiation Therapy Followed by Docetaxel Consolidation in Patients With Inoperable Squamous Cell Lung Cancer - A Study of ZEN003694 in People With Squamous Cell Lung Cancer - A Survival Observational Study in Patients With Advanced IIIB-IV Squamous Cell Lung Cancer Receiving PD-1 Combination With Chemotherapy - A Trial With Metronomic Low-dose Treosulfan, Pioglitazone and Clarithromycin Versus Standard Treatment in NSCLC - Adherence to Survivorship Care Guidelines in Health Care Providers for Non-Small Cell Lung Cancer and Colorectal Cancer Survivor Care - An Open-label, Randomized, Parallel, Non Comparative, Phase II Trial of Nivolumab Plus Ipilimumab Versus Platinum-based Chemotherapy Plus Nivolumab in Chemonaive Metastatic or Recurrent Squamous-Cell Lung Cancer (SqLC) - An Phase I Trial of a CAR T-cell Infusion C-CAR031 in Participants With GPC3+ Advanced/Metastatic Squamous Cell Lung Cancer - Anti-GPC3 CAR T for Recurrent or Refractory Lung Squamous Cell Carcinoma - Apatinib for Advanced Lung Squmamous Carcinoma - APOLLO 11, Consortium of Italian Centers Involved in Treatment of Patients With Lung Cancer Treated With Innovative Therapies: Real World Data and Translational Reaserch ### Approved drugs (2) - [Cetuximab](https://trialight.com/data/asset/cetuximab-a1f8c65c-bae1-4b77-9491-dca37aeeaa3c.md) - [Pembrolizumab](https://trialight.com/data/asset/pembrolizumab-f9ac1934-47a5-4a53-ae55-20b7d53d8815.md) ### Drugs in development (59) - Aldesleukin Phase 1 - Apatorsen Phase 2 - Auranofin Phase 1 - [Bevacizumab](https://trialight.com/data/asset/bevacizumab-a9e09d09-2d3c-4fda-ad45-01fd000dd363.md) Phase 2 - Bleomycin A6 Phase 2 - Camrelizumab Phase 3 - [Carboplatin](https://trialight.com/data/asset/carboplatin-91aa6947-1cbb-486a-b5c6-aaaa6868e24e.md) Phase 3 - [Cisplatin](https://trialight.com/data/asset/cisplatin-e039621a-d679-4740-88ac-94842bf4a91e.md) Phase 3 - Clarithromycin Phase 2 - [Cyclophosphamide](https://trialight.com/data/asset/cyclophosphamide-25b75968-e3cd-410a-9b24-0c349d8f7663.md) Phase 3 - Dasatinib anhydrous Phase 2 - [Dexamethasone](https://trialight.com/data/asset/dexamethasone-b923ddae-f095-408c-96e9-975238a429ad.md) Phase 2 - [Docetaxel](https://trialight.com/data/asset/docetaxel-3c835086-a86f-4a89-abb6-45847fbab5d6.md) Phase 3 - [Durvalumab](https://trialight.com/data/asset/durvalumab-bca7c265-7862-46e1-bf29-3dd2fdda4954.md) Phase 3 - Erdafitinib Phase 2 - Erlotinib hydrochloride Phase 2 - Etoposide Phase 3 - Fexagratinib Phase 2 - Fludarabine Phase 1 - Gefitinib Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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