> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/condition/smoldering-plasma-cell-myeloma-2df90d99-88b3-53ff-adb8-a9c88ee1b83e > Record changed: 2026-11-04 # Smoldering plasma cell myeloma Therapeutic area Immunology Rare disease No ## Definition and classification **Definition** A plasma cell myeloma lacking clinical manifestations and organ impairment. **Genetic basis** No **Non-human condition** No **Rare disease** No **Listing at source** Listed **Condition name** Smoldering plasma cell myeloma **Therapeutic area** Immunology ### Alternative names (10) - smoldering plasma cell myeloma - asymptomatic myeloma - asymptomatic plasma cell myeloma - smoldering multiple myeloma - Smoldering Multiple Myeloma (SMM) - smoldering Multiple myeloma/plasma cell myeloma - smoldering myeloma - smouldering multiple myeloma - smouldering Multiple myeloma/plasma cell myeloma - smouldering myeloma ## Clinical profile **Severity** Mild ### All therapeutic areas (3) - Hematology - Immunology - Oncology Sources for recorded values Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005235) ## Identifiers **MONDO ID** MONDO:0005235 Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0005235) **Parent condition** MONDO:0009693 ## Related records ### Broader conditions (22) - [B-cell neoplasm](https://trialight.com/data/condition/b-cell-neoplasm-ffd0710d-7dbd-55bc-a4a5-3c1cf532bac2.md) - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) - Cancer or benign tumor - Disease - Disease by body system or component - Disease by etiologic mechanism - Hematologic disorder - [Hematopoietic and lymphoid cell neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-cell-neoplasm-ed3616fa-22fe-5984-94b4-745416e01ef9.md) - [Hematopoietic and lymphoid system neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-system-neoplasm-510101ac-7ce5-5dd1-8980-f2f110effdf0.md) - Human disease - Immune system cancer - [Immune system disorder](https://trialight.com/data/condition/immune-system-disorder-24846188-b462-515c-bb34-142255a648c8.md) - Leukocyte disorder - Lymphoid hemopathy - Lymphoid neoplasm - [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) - Myeloid neoplasm - [Neoplasm](https://trialight.com/data/condition/neoplasm-2a973797-359b-5982-907e-98f9b7c1a284.md) - Neoplasm of mature B-cells - Neoplastic disease or syndrome ### Narrower conditions (1) - Indolent plasma cell myeloma ### Trials (104) - A Cohort Study of Plasma Cell Disorders (PCDs) in PKUFH - A Nationwide Phase 2 Trial of Patients With Smoldering and Active Multiple Myeloma (MM) - A Phase II Study of BI-505 in Smoldering Multiple Myeloma - A Phase II Trial If Nivolumab, Lenalidomide and Dexamethasone in High Risk Smoldering Myeloma - A Phase II Trial of Anti-KIR in Smoldering Multiple Myeloma - A Proof-of-Concept Study to Learn Whether Linvoseltamab Can Eliminate Abnormal Plasma Cells That May Lead to Multiple Myeloma in Adult Patients With High-Risk Monoclonal Gammopathy of Undetermined Significance or Non-High-Risk Smoldering Multiple Myeloma - A Proof-of-Concept Trial to Study the Safety and Activity of Linvoseltamab in Adult Participants With Smoldering Multiple Myeloma at High Risk of Developing Multiple Myeloma - A Prospective Multicenter Study of the Effects of Plant-based Diets on Gut Microbiome and Derived Metabolites in Patients Affected by Smoldering Multiple Myeloma - A Real-world Study in Participants With Smoldering Multiple Myeloma - A Study Comparing a Plant-Based Diet With Supplements and Placebo in People With Monoclonal Gammopathy of Undetermined Significance (MGUS) or Smoldering Multiple Myeloma (SMM) - A Study Evaluating the Effects of Siltuximab on the Heart in Patients With Monoclonal Gammopathy of Undetermined Significance, Smoldering Multiple Myeloma, or Indolent Multiple Myeloma - A Study of a Plant-Based Diet and Dietary Supplements in People With Smoldering Multiple Myeloma (SMM) or Monoclonal Gammopathy of Undetermined Significance (MGUS) - A Study of a Plant-Based Diet in People With Monoclonal Gammopathy of Undetermined Significance (MGUS) or Smoldering Multiple Myeloma (SMM) - [A Study of JNJ-79635322 in Combination With Daratumumab With or Without Lenalidomide for Multiple Myeloma, Newly Diagnosed AL Amyloidosis, and High-risk Smoldering Multiple Myeloma or JNJ-79635322 in Combination With Pomalidomide for Multiple Myeloma](https://trialight.com/data/trial/a-study-of-jnj-79635322-in-combination-with-daratumumab-with-3f3937c7-ea81-4ff0-9faf-370e3b5825ee.md) - A Study of PVX-410, a Cancer Vaccine, and Citarinostat +/- Lenalidomide for Smoldering MM - A Study of Siltuximab (Anti- IL 6 Monoclonal Antibody) in Patients With High-risk Smoldering Multiple Myeloma - A Study of Subcutaneous Daratumumab Versus Active Monitoring in Participants With High-Risk Smoldering Multiple Myeloma - A Study to Compare Linvoseltamab and Daratumumab Treatment in High-Risk Smoldering Multiple Myeloma (HR-SMM) - A Study to Evaluate 3 Dose Schedules of Daratumumab in Participants With Smoldering Multiple Myeloma - A Trial of TBL12 Sea Cucumber Extract in Patients With Untreated Asymptomatic Myeloma ### Drugs in development (28) - Anakinra Phase 1 - Belantamab mafodotin Phase 1 - [Bortezomib](https://trialight.com/data/asset/bortezomib-35a853cf-26ab-4a4c-a405-ae671d364aad.md) Phase 1 - [Carfilzomib](https://trialight.com/data/asset/carfilzomib-42f49602-1f34-4e14-b345-79d6fd69324f.md) Phase 2 - [Cholestyramine](https://trialight.com/data/asset/cholestyramine-02403ab6-2c23-416a-ba64-dd03a00539a1.md) Phase 2 - Ciltacabtagene autoleucel Phase 2 - [Daratumumab](https://trialight.com/data/asset/daratumumab-28c327e5-1741-4dd5-89d4-6562e941ab50.md) Phase 3 - [Dexamethasone](https://trialight.com/data/asset/dexamethasone-b923ddae-f095-408c-96e9-975238a429ad.md) Phase 3 - Elotuzumab Phase 2 - [Elranatamab](https://trialight.com/data/asset/elranatamab-43094116-a114-45cf-88c8-60ef9865def2.md) Phase 2 - [Hyaluronidase (human recombinant)](https://trialight.com/data/asset/hyaluronidase-human-recombinant-2ffd4cc0-072b-4151-9944-5ed298381155.md) Phase 3 - [Iberdomide](https://trialight.com/data/asset/iberdomide-c87e8a0b-9d3e-422e-9876-8c8310fab473.md) Phase 2 - Iberdomide hydrochloride Phase 2 - Incomplete freund'S adjuvant Phase 1 - [Isatuximab](https://trialight.com/data/asset/isatuximab-a4041fba-ee04-4ad4-a6fc-39e24da4aedb.md) Phase 2 - Ixazomib citrate Phase 2 - Leflunomide Phase 2 - [Lenalidomide](https://trialight.com/data/asset/lenalidomide-1e614dfb-efd0-4006-a121-30a97656c7a9.md) Phase 3 - Lenalidomide hydrochloride monohydrate Phase 3 - [Linvoseltamab](https://trialight.com/data/asset/linvoseltamab-ce410b5b-5456-425a-8d0a-3924dff79a86.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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