> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/condition/simpson-golabi-behmel-syndrome-3df5b928-b9aa-5289-915e-12a2489fc373
> Record changed: 2026-10-13

# Simpson-Golabi-Behmel syndrome

Rare disease

Yes

## Definition and classification

**Definition**

Simpson-Golabi-Behmel syndrome is a rare X-linked multiple congenital anomalies syndrome, characterized by pre- and postnatal overgrowth, distinctive craniofacial features, variable congenital malformations, organomegaly and an increased tumor risk.

**Genetic basis**

No

**Non-human condition**

No

**Rare disease**

Yes

**Listing at source**

Listed

**Condition name**

Simpson-Golabi-Behmel syndrome

### Alternative names (9)

- Simpson-Golabi-Behmel syndrome
- DGSX
- Golabi-Rosen syndrome
- SDYS
- SGB syndrome
- SGBS
- Sara Angers syndrome
- Simpson-Golabi-Behmel syndrome
- X-linked dysplasia gigantism syndrome

## Clinical profile

**Severity**

Severe

### Disease mechanisms (2)

- Developmental
- Syndromic

## Identifiers

**MONDO ID**

MONDO:0010731

Source: [monarchinitiative.org](https://monarchinitiative.org/MONDO:0010731)

**Parent condition**

MONDO:0002254

## Related records

### Broader conditions (7)

- Disease
- Disease by body system or component
- Disease by developmental or physiological process
- Disorder of development or morphogenesis
- Human disease
- Overgrowth syndrome
- Syndromic disease

### Narrower conditions (2)

- Simpson-Golabi-Behmel syndrome type 1
- Simpson-Golabi-Behmel syndrome type 2

### Trials (15)

- [A Phase 1 Study of BGB-B2033, Alone or in Combination With Tislelizumab With or Without Bevacizumab, in Participants With Advanced or Metastatic Solid Tumors](https://trialight.com/data/trial/a-phase-1-study-of-bgb-b2033-alone-or-in-combination-with-731a5f45-9fa7-4c48-93c4-235fe2f95cb3.md)
- A Study of Codrituzumab in Children and Young Adults With Solid Tumors and Have Not Responded to Treatment or Have Come Back After Treatment
- A Study of MT-303 in Adults With Advanced or Metastatic GPC3-Expressing Cancers, Including HCC
- A Study to Evaluate the Tolerability, Safety, and PK of AST-201 in Patients With GPC3-positive Advanced Solid Tumors
- Assessment of Glypican 3 as Apredictive Marker in Colorectal Cancer Patients
- CAR-T Cell Immunotherapy for HCC Targeting GPC3
- Dual-Target GPC3/B7-H3 CAR-NK Cells for Advanced HCC
- First in Human Study to Evaluate AZD9793 in Participants With Advanced or Metastatic Solid Tumours
- Glypican-3 as a Prognostic Factor in Patients With Hepatocellular Carcinoma Treated by Immunotherapy
- GPC3 CAR T Cells With IL-15 and IL-21 for Recurrent ATRT and CNS Rhabdoid Tumors (RADIANT)
- GPC3-CAR-T Cells for Immunotherapy of Cancer With GPC3 Expression
- GPC3-targeted CAR-T Cell for Treating GPC3 Positive Advanced HCC
- GPC3-Targeted PET/CT in Hepatocellular Carcinoma
- Risk Factors of Atrial Fibrillation After Cardiac Surgery
- Target-specific immunoPET Imaging of Digestive System Carcinoma

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